Single cell type - SLC52A2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC52A2
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 52 member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes FDA approved drug targets Human disease related genes Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	21

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (MCF7, PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SLC52A2 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BRMS1	BRMS1 transcriptional repressor and anoikis regulator	0.7087	53
DOHH	Deoxyhypusine hydroxylase	0.6613	39
TOMM40	Translocase of outer mitochondrial membrane 40	0.6420	39
MPDU1	Mannose-P-dolichol utilization defect 1	0.6395	53
MED16	Mediator complex subunit 16	0.6360	53
ATP13A1	ATPase 13A1	0.6199	53
MYO1C	Myosin IC	0.6125	53
NOXO1	NADPH oxidase organizer 1	0.6105	53
SEC61A1	SEC61 translocon subunit alpha 1	0.6082	53
RABL6	RAB, member RAS oncogene family like 6	0.6071	53
RPUSD1	RNA pseudouridine synthase domain containing 1	0.6059	56
TRPM4	Transient receptor potential cation channel subfamily M member 4	0.6038	53
MRPL12	Mitochondrial ribosomal protein L12	0.6034	53
UGT2B17	UDP glucuronosyltransferase family 2 member B17	0.6005	53
APEH	Acylaminoacyl-peptide hydrolase	0.5935	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.9 nTPM
Breast	39.5 nTPM
Adipose tissue	24.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	8.7 nTPM
Lung	8.7 nTPM

Astrocytes	5.5 nTPM
Brain	5.5 nTPM

B-cells	24.3 nTPM
Liver	50.1 nTPM
Breast	37.5 nTPM
PBMC	28.5 nTPM
Colon	27.1 nTPM
Stomach	22.3 nTPM
Spleen	20.4 nTPM
Adipose tissue	17.1 nTPM
Kidney	14.3 nTPM
Lymph node	12.9 nTPM
Bone marrow	12.3 nTPM

Dendritic cells	36.3 nTPM
PBMC	43.8 nTPM
Breast	39.0 nTPM
Adipose tissue	26.0 nTPM

Endothelial cells	24.3 nTPM
Ovary	46.6 nTPM
Pancreas	38.6 nTPM
Placenta	35.8 nTPM
Prostate	31.5 nTPM
Eye	30.7 nTPM
Breast	29.8 nTPM
Endometrium	28.7 nTPM
Skin	22.7 nTPM
Testis	16.6 nTPM
Skeletal muscle	16.5 nTPM
Heart muscle	15.8 nTPM
Liver	15.6 nTPM
Esophagus	11.8 nTPM
Lung	0.0 nTPM

Fibroblasts	22.2 nTPM
Placenta	44.6 nTPM
Prostate	31.4 nTPM
Skin	26.9 nTPM
Adipose tissue	23.7 nTPM
Stomach	22.3 nTPM
Breast	22.1 nTPM
Ovary	20.7 nTPM
Skeletal muscle	19.1 nTPM
Heart muscle	13.8 nTPM
Esophagus	10.3 nTPM
Lung	8.9 nTPM

Intestinal goblet cells	56.3 nTPM
Colon	101.5 nTPM
Small intestine	37.6 nTPM
Rectum	29.8 nTPM

Macrophages	21.4 nTPM
Pancreas	61.2 nTPM
Ovary	38.3 nTPM
Breast	28.1 nTPM
Prostate	26.3 nTPM
Kidney	25.7 nTPM
Stomach	23.5 nTPM
Adipose tissue	21.6 nTPM
Testis	20.3 nTPM
Endometrium	19.8 nTPM
Skeletal muscle	14.0 nTPM
Esophagus	12.6 nTPM
Bone marrow	11.3 nTPM
Spleen	9.3 nTPM
Lung	8.5 nTPM
PBMC	0.0 nTPM

Paneth cells	46.7 nTPM
Colon	52.6 nTPM
Small intestine	45.0 nTPM
Rectum	42.4 nTPM

Plasma cells	43.3 nTPM
Stomach	68.2 nTPM
Spleen	66.4 nTPM
Bone marrow	46.2 nTPM
Esophagus	18.4 nTPM
Adipose tissue	17.4 nTPM

Respiratory ciliated cells	11.7 nTPM
Bronchus	19.0 nTPM
Lung	4.4 nTPM

Smooth muscle cells	31.1 nTPM
Pancreas	110.3 nTPM
Ovary	51.4 nTPM
Prostate	29.7 nTPM
Breast	27.5 nTPM
Skin	22.0 nTPM
Skeletal muscle	20.9 nTPM
Bronchus	19.5 nTPM
Adipose tissue	18.8 nTPM
Endometrium	17.9 nTPM
Heart muscle	13.2 nTPM
Esophagus	10.9 nTPM

T-cells	24.8 nTPM
Ovary	46.7 nTPM
Prostate	42.6 nTPM
Skin	36.8 nTPM
Colon	36.1 nTPM
Breast	31.3 nTPM
Adipose tissue	25.3 nTPM
Stomach	25.0 nTPM
Bone marrow	23.2 nTPM
Skeletal muscle	22.6 nTPM
Spleen	21.6 nTPM
Kidney	21.2 nTPM
Liver	20.9 nTPM
Endometrium	20.0 nTPM
PBMC	19.6 nTPM
Lymph node	17.7 nTPM
Lung	10.6 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	31.2 nTPM
Skin	31.2 nTPM

Basal prostatic cells	27.0 nTPM
Prostate	27.0 nTPM

Basal respiratory cells	41.5 nTPM
Bronchus	41.5 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Undifferentiated cells	65.6 nTPM
Colon	107.1 nTPM
Rectum	46.1 nTPM
Small intestine	43.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC