Single cell type - MRPL55 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRPL55
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial ribosomal protein L55
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	26

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MRPL55 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TIMM10	Translocase of inner mitochondrial membrane 10	0.6399	39
HMGN5	High mobility group nucleosome binding domain 5	0.5487	67
C19orf53	Chromosome 19 open reading frame 53	0.5455	39
NDUFA11	NADH:ubiquinone oxidoreductase subunit A11	0.5343	39
CHCHD5	Coiled-coil-helix-coiled-coil-helix domain containing 5	0.5152	39
OXT	Oxytocin/neurophysin I prepropeptide	0.5060	67
EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.4963	39
AFP	Alpha fetoprotein	0.4951	67
IMP4	IMP U3 small nucleolar ribonucleoprotein 4	0.4848	39
SOD1	Superoxide dismutase 1	0.4821	67
DHRS12	Dehydrogenase/reductase 12	0.4734	67
POLR2L	RNA polymerase II, I and III subunit L	0.4729	39
DDX18	DEAD-box helicase 18	0.4695	39
DDT	D-dopachrome tautomerase	0.4641	2
MRPS12	Mitochondrial ribosomal protein S12	0.4588	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	41.6 nTPM
Breast	52.0 nTPM
Adipose tissue	31.1 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	59.4 nTPM
Lung	59.4 nTPM

Astrocytes	9.1 nTPM
Brain	9.1 nTPM

B-cells	58.9 nTPM
Liver	150.9 nTPM
Kidney	90.4 nTPM
Breast	72.2 nTPM
Colon	60.7 nTPM
PBMC	57.1 nTPM
Spleen	41.5 nTPM
Stomach	36.8 nTPM
Bone marrow	31.1 nTPM
Adipose tissue	27.0 nTPM
Lymph node	21.2 nTPM

Dendritic cells	50.4 nTPM
PBMC	63.8 nTPM
Breast	43.8 nTPM
Adipose tissue	43.7 nTPM

Endothelial cells	55.7 nTPM
Pancreas	84.9 nTPM
Skin	83.9 nTPM
Heart muscle	74.3 nTPM
Liver	74.3 nTPM
Breast	71.8 nTPM
Placenta	68.2 nTPM
Testis	55.4 nTPM
Ovary	54.9 nTPM
Eye	43.7 nTPM
Skeletal muscle	41.1 nTPM
Prostate	39.2 nTPM
Esophagus	39.2 nTPM
Endometrium	30.0 nTPM
Lung	18.7 nTPM

Fibroblasts	59.3 nTPM
Placenta	98.1 nTPM
Heart muscle	84.2 nTPM
Skin	82.6 nTPM
Breast	75.9 nTPM
Ovary	73.1 nTPM
Adipose tissue	49.7 nTPM
Skeletal muscle	45.3 nTPM
Prostate	42.4 nTPM
Esophagus	41.2 nTPM
Lung	31.3 nTPM
Stomach	28.2 nTPM

Intestinal goblet cells	105.1 nTPM
Colon	163.0 nTPM
Small intestine	82.8 nTPM
Rectum	69.5 nTPM

Macrophages	54.9 nTPM
Kidney	128.6 nTPM
Pancreas	102.0 nTPM
Ovary	66.8 nTPM
Prostate	66.4 nTPM
Lung	63.7 nTPM
Testis	59.2 nTPM
Breast	58.8 nTPM
Esophagus	56.6 nTPM
Adipose tissue	42.1 nTPM
Endometrium	39.0 nTPM
Spleen	38.4 nTPM
Skeletal muscle	36.5 nTPM
Bone marrow	36.3 nTPM
Stomach	29.4 nTPM
PBMC	0.0 nTPM

Paneth cells	69.8 nTPM
Small intestine	75.1 nTPM
Rectum	68.5 nTPM
Colon	65.8 nTPM

Plasma cells	79.3 nTPM
Spleen	123.5 nTPM
Bone marrow	82.4 nTPM
Stomach	78.5 nTPM
Esophagus	74.0 nTPM
Adipose tissue	38.0 nTPM

Respiratory ciliated cells	73.6 nTPM
Bronchus	96.2 nTPM
Lung	51.0 nTPM

Smooth muscle cells	69.8 nTPM
Pancreas	129.2 nTPM
Heart muscle	119.0 nTPM
Skin	100.8 nTPM
Bronchus	64.0 nTPM
Prostate	62.5 nTPM
Breast	60.5 nTPM
Skeletal muscle	54.4 nTPM
Ovary	54.2 nTPM
Esophagus	51.2 nTPM
Endometrium	36.0 nTPM
Adipose tissue	35.7 nTPM

T-cells	50.6 nTPM
Kidney	93.1 nTPM
Skin	92.0 nTPM
PBMC	68.2 nTPM
Prostate	66.3 nTPM
Liver	64.5 nTPM
Lung	51.6 nTPM
Colon	48.5 nTPM
Ovary	46.7 nTPM
Breast	45.9 nTPM
Stomach	41.0 nTPM
Spleen	39.0 nTPM
Adipose tissue	37.3 nTPM
Bone marrow	35.3 nTPM
Skeletal muscle	34.5 nTPM
Endometrium	33.7 nTPM
Esophagus	32.8 nTPM
Lymph node	29.7 nTPM

Basal keratinocytes	76.3 nTPM
Skin	76.3 nTPM

Basal prostatic cells	71.5 nTPM
Prostate	71.5 nTPM

Basal respiratory cells	131.8 nTPM
Bronchus	131.8 nTPM

Basal squamous epithelial cells	44.3 nTPM
Esophagus	44.3 nTPM

Undifferentiated cells	94.1 nTPM
Colon	119.1 nTPM
Small intestine	86.1 nTPM
Rectum	77.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC