Single cell type - NDUFA11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFA11
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit A11
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFA11 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
POLR2L	RNA polymerase II, I and III subunit L	0.6584	39
NDUFS6	NADH:ubiquinone oxidoreductase subunit S6	0.6458	39
NDUFB1	NADH:ubiquinone oxidoreductase subunit B1	0.6340	54
MRPS36	Mitochondrial ribosomal protein S36	0.6333	39
SUCLG2	Succinate-CoA ligase GDP-forming subunit beta	0.6182	53
COX6B1	Cytochrome c oxidase subunit 6B1	0.6136	39
COX14	Cytochrome c oxidase assembly factor COX14	0.6093	39
NDUFA3	NADH:ubiquinone oxidoreductase subunit A3	0.6022	39
EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.5965	39
MRPL54	Mitochondrial ribosomal protein L54	0.5954	39
ZNHIT1	Zinc finger HIT-type containing 1	0.5898	67
COX7C	Cytochrome c oxidase subunit 7C	0.5893	39
COX7B	Cytochrome c oxidase subunit 7B	0.5802	39
CHCHD10	Coiled-coil-helix-coiled-coil-helix domain containing 10	0.5725	39
COX8A	Cytochrome c oxidase subunit 8A	0.5716	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	189.9 nTPM
Breast	214.1 nTPM
Adipose tissue	165.8 nTPM

Alveolar cells type 1	144.2 nTPM
Lung	144.2 nTPM

Alveolar cells type 2	198.0 nTPM
Lung	198.0 nTPM

Astrocytes	22.5 nTPM
Brain	22.5 nTPM

B-cells	179.2 nTPM
Liver	489.0 nTPM
Kidney	214.3 nTPM
Colon	204.4 nTPM
Breast	191.2 nTPM
PBMC	168.4 nTPM
Adipose tissue	133.9 nTPM
Spleen	113.1 nTPM
Bone marrow	109.5 nTPM
Stomach	85.0 nTPM
Lymph node	83.2 nTPM

Dendritic cells	164.2 nTPM
PBMC	211.2 nTPM
Adipose tissue	152.1 nTPM
Breast	129.4 nTPM

Endothelial cells	175.6 nTPM
Placenta	321.1 nTPM
Breast	259.0 nTPM
Liver	252.3 nTPM
Pancreas	239.4 nTPM
Skin	192.8 nTPM
Testis	190.9 nTPM
Lung	165.3 nTPM
Heart muscle	149.2 nTPM
Prostate	138.0 nTPM
Skeletal muscle	137.3 nTPM
Ovary	134.9 nTPM
Eye	118.9 nTPM
Endometrium	94.1 nTPM
Esophagus	65.6 nTPM

Enteroendocrine cells	351.5 nTPM
Colon	373.0 nTPM
Rectum	330.0 nTPM

Erythroid cells	208.9 nTPM
Liver	251.4 nTPM
Bone marrow	166.5 nTPM

Fibroblasts	224.3 nTPM
Placenta	485.8 nTPM
Adipose tissue	306.9 nTPM
Skin	286.0 nTPM
Breast	268.8 nTPM
Heart muscle	230.0 nTPM
Lung	205.6 nTPM
Ovary	169.7 nTPM
Prostate	161.2 nTPM
Skeletal muscle	152.2 nTPM
Esophagus	104.7 nTPM
Stomach	96.5 nTPM

Intestinal goblet cells	477.0 nTPM
Colon	664.0 nTPM
Rectum	383.8 nTPM
Small intestine	383.2 nTPM

Macrophages	197.7 nTPM
Kidney	490.9 nTPM
Pancreas	331.8 nTPM
Lung	240.9 nTPM
Bone marrow	206.1 nTPM
Adipose tissue	205.0 nTPM
Testis	196.9 nTPM
Breast	169.2 nTPM
Prostate	165.1 nTPM
Spleen	162.8 nTPM
Skeletal muscle	159.2 nTPM
Endometrium	150.7 nTPM
Ovary	137.0 nTPM
Stomach	131.9 nTPM
PBMC	109.1 nTPM
Esophagus	108.6 nTPM

Paneth cells	446.6 nTPM
Colon	619.3 nTPM
Small intestine	375.4 nTPM
Rectum	345.1 nTPM

Plasma cells	208.5 nTPM
Spleen	321.8 nTPM
Bone marrow	271.9 nTPM
Stomach	196.3 nTPM
Adipose tissue	147.8 nTPM
Esophagus	104.7 nTPM

Respiratory ciliated cells	176.7 nTPM
Bronchus	179.9 nTPM
Lung	173.5 nTPM

Basal prostatic cells	236.8 nTPM
Prostate	236.8 nTPM

Basal respiratory cells	306.8 nTPM
Bronchus	306.8 nTPM

Basal squamous epithelial cells	99.6 nTPM
Esophagus	99.6 nTPM

Cholangiocytes	267.4 nTPM
Liver	267.4 nTPM

Smooth muscle cells	210.0 nTPM
Pancreas	461.5 nTPM
Breast	258.3 nTPM
Heart muscle	239.2 nTPM
Skin	239.2 nTPM
Adipose tissue	220.1 nTPM
Skeletal muscle	202.2 nTPM
Prostate	191.6 nTPM
Ovary	172.1 nTPM
Endometrium	120.1 nTPM
Esophagus	113.2 nTPM
Bronchus	92.8 nTPM

T-cells	156.9 nTPM
Kidney	267.6 nTPM
Liver	235.9 nTPM
PBMC	221.3 nTPM
Lung	205.0 nTPM
Colon	198.6 nTPM
Skin	192.0 nTPM
Adipose tissue	167.1 nTPM
Bone marrow	155.9 nTPM
Spleen	140.5 nTPM
Breast	137.9 nTPM
Skeletal muscle	126.1 nTPM
Ovary	120.1 nTPM
Endometrium	114.5 nTPM
Prostate	113.7 nTPM
Lymph node	110.9 nTPM
Stomach	106.9 nTPM
Esophagus	52.4 nTPM

Undifferentiated cells	451.1 nTPM
Colon	548.3 nTPM
Rectum	417.2 nTPM
Small intestine	387.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC