Cell line - TOPBP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TOPBP1
Gene descriptionⁱ Full gene name according to HGNC.	DNA topoisomerase II binding protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	U-698-M & Daudi - Adaptive immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

TOPBP1 is part of cluster 27 U-698-M & Daudi - Adaptive immune response with confidenceⁱ 1
505 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TCL1B	TCL1 family AKT coactivator B	0.7609	27
IGHV2-70	Immunoglobulin heavy variable 2-70	0.7599	27
ENSA	Endosulfine alpha	0.7543	27
NPAT	Nuclear protein, coactivator of histone transcription	0.7543	27
CAPSL	Calcyphosine like	0.7534	27
IGHV4-34	Immunoglobulin heavy variable 4-34	0.7532	27
TRAJ59	T cell receptor alpha joining 59 (non-functional)	0.7530	27
TRAJ52	T cell receptor alpha joining 52	0.7530	27
TRAJ30	T cell receptor alpha joining 30	0.7530	27
TEX29	Testis expressed 29	0.7512	27
CXCR5	C-X-C motif chemokine receptor 5	0.7502	27
CFAP73	Cilia and flagella associated protein 73	0.7498	27
IGKV2D-26	Immunoglobulin kappa variable 2D-26	0.7490	27
RFC3	Replication factor C subunit 3	0.7478	27
S100Z	S100 calcium binding protein Z	0.7470	27