Single cell type - ELP6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ELP6
Gene descriptionⁱ Full gene name according to HGNC.	Elongator acetyltransferase complex subunit 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ELP6 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RNASEH2C	Ribonuclease H2 subunit C	0.5530	52
ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit	0.5299	40
ACSM3	Acyl-CoA synthetase medium chain family member 3	0.5294	40
TRAPPC4	Trafficking protein particle complex 4	0.5257	40
MRPL16	Mitochondrial ribosomal protein L16	0.5166	39
HSD3B2	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.5155	52
KNL1	Kinetochore scaffold 1	0.5143	12
ZNF428	Zinc finger protein 428	0.5067	39
TRMU	TRNA mitochondrial 2-thiouridylase	0.5050	52
TXN2	Thioredoxin 2	0.5015	39
SULT1C4	Sulfotransferase family 1C member 4	0.5005	40
RHBG	Rh family B glycoprotein	0.4990	40
GVQW3	GVQW motif containing 3	0.4935	52
GTF3C5	General transcription factor IIIC subunit 5	0.4855	52
NPIPB2	Nuclear pore complex interacting protein family member B2	0.4832	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.3 nTPM
Breast	26.4 nTPM
Adipose tissue	12.2 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	12.3 nTPM
Lung	12.3 nTPM

Astrocytes	8.8 nTPM
Brain	8.8 nTPM

B-cells	24.9 nTPM
Liver	38.7 nTPM
PBMC	31.5 nTPM
Colon	30.3 nTPM
Kidney	28.5 nTPM
Stomach	26.8 nTPM
Breast	22.8 nTPM
Spleen	21.5 nTPM
Bone marrow	18.8 nTPM
Lymph node	15.1 nTPM
Adipose tissue	14.6 nTPM

Dendritic cells	27.8 nTPM
Breast	33.9 nTPM
Adipose tissue	25.6 nTPM
PBMC	23.9 nTPM

Endothelial cells	22.6 nTPM
Ovary	36.6 nTPM
Placenta	36.4 nTPM
Eye	32.4 nTPM
Testis	32.3 nTPM
Liver	32.1 nTPM
Pancreas	23.1 nTPM
Breast	21.6 nTPM
Endometrium	21.2 nTPM
Esophagus	16.0 nTPM
Lung	15.6 nTPM
Skeletal muscle	13.7 nTPM
Prostate	12.4 nTPM
Skin	12.2 nTPM
Heart muscle	10.8 nTPM

Fibroblasts	23.4 nTPM
Ovary	55.3 nTPM
Placenta	37.3 nTPM
Breast	31.3 nTPM
Esophagus	24.6 nTPM
Adipose tissue	22.8 nTPM
Skeletal muscle	18.7 nTPM
Skin	16.4 nTPM
Stomach	16.3 nTPM
Lung	13.4 nTPM
Prostate	12.7 nTPM
Heart muscle	8.1 nTPM

Intestinal goblet cells	15.0 nTPM
Small intestine	16.7 nTPM
Colon	16.5 nTPM
Rectum	12.0 nTPM

Macrophages	17.4 nTPM
PBMC	40.9 nTPM
Pancreas	28.0 nTPM
Kidney	21.9 nTPM
Ovary	20.4 nTPM
Breast	18.7 nTPM
Stomach	17.6 nTPM
Bone marrow	17.5 nTPM
Endometrium	16.4 nTPM
Testis	15.7 nTPM
Prostate	13.8 nTPM
Lung	11.7 nTPM
Esophagus	11.0 nTPM
Adipose tissue	9.8 nTPM
Skeletal muscle	9.7 nTPM
Spleen	8.3 nTPM

Paneth cells	12.7 nTPM
Small intestine	18.8 nTPM
Rectum	16.2 nTPM
Colon	3.3 nTPM

Plasma cells	23.1 nTPM
Spleen	31.5 nTPM
Bone marrow	31.3 nTPM
Adipose tissue	23.9 nTPM
Stomach	22.4 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	15.7 nTPM
Lung	16.0 nTPM
Bronchus	15.4 nTPM

Smooth muscle cells	22.6 nTPM
Pancreas	43.7 nTPM
Ovary	31.9 nTPM
Esophagus	26.4 nTPM
Breast	25.0 nTPM
Heart muscle	21.3 nTPM
Skin	20.9 nTPM
Endometrium	20.8 nTPM
Skeletal muscle	17.5 nTPM
Adipose tissue	16.1 nTPM
Prostate	13.8 nTPM
Bronchus	11.2 nTPM

T-cells	23.9 nTPM
Kidney	41.1 nTPM
Esophagus	39.3 nTPM
Liver	37.3 nTPM
PBMC	33.2 nTPM
Colon	28.5 nTPM
Ovary	26.7 nTPM
Bone marrow	25.2 nTPM
Stomach	21.6 nTPM
Spleen	20.9 nTPM
Adipose tissue	20.3 nTPM
Breast	20.3 nTPM
Skeletal muscle	18.5 nTPM
Skin	16.6 nTPM
Endometrium	16.5 nTPM
Lymph node	15.3 nTPM
Lung	15.2 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	8.4 nTPM
Skin	8.4 nTPM

Basal respiratory cells	35.7 nTPM
Bronchus	35.7 nTPM

Basal squamous epithelial cells	19.4 nTPM
Esophagus	19.4 nTPM

Cholangiocytes	24.3 nTPM
Liver	24.3 nTPM

Undifferentiated cells	21.7 nTPM
Small intestine	27.2 nTPM
Colon	21.2 nTPM
Rectum	16.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC