Single cell type - TRAPPC4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRAPPC4
Gene descriptionⁱ Full gene name according to HGNC.	Trafficking protein particle complex 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRAPPC4 is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MAGED2	MAGE family member D2	0.7909	40
HS3ST1	Heparan sulfate-glucosamine 3-sulfotransferase 1	0.7712	40
CRYGD	Crystallin gamma D	0.7152	40
OR8D4	Olfactory receptor family 8 subfamily D member 4	0.7103	40
NDP	Norrin cystine knot growth factor NDP	0.7062	40
CEACAM21	CEA cell adhesion molecule 21	0.7041	40
AMH	Anti-Mullerian hormone	0.6979	40
NECTIN1	Nectin cell adhesion molecule 1	0.6932	40
IHH	Indian hedgehog signaling molecule	0.6797	40
ALKAL2	ALK and LTK ligand 2	0.6795	40
DHH	Desert hedgehog signaling molecule	0.6760	40
INHBB	Inhibin subunit beta B	0.6753	40
LCMT1	Leucine carboxyl methyltransferase 1	0.6628	40
RBP1	Retinol binding protein 1	0.6618	40
DCAF12L2	DDB1 and CUL4 associated factor 12 like 2	0.6560	40

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	50.3 nTPM
Breast	59.9 nTPM
Adipose tissue	40.8 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	34.4 nTPM
Lung	34.4 nTPM

Astrocytes	7.5 nTPM
Brain	7.5 nTPM

B-cells	38.8 nTPM
Kidney	57.1 nTPM
Colon	55.9 nTPM
Liver	53.3 nTPM
PBMC	48.5 nTPM
Adipose tissue	43.1 nTPM
Breast	29.4 nTPM
Lymph node	27.2 nTPM
Spleen	26.9 nTPM
Stomach	24.5 nTPM
Bone marrow	22.1 nTPM

Dendritic cells	61.1 nTPM
Adipose tissue	74.6 nTPM
Breast	56.9 nTPM
PBMC	51.8 nTPM

Endothelial cells	47.7 nTPM
Placenta	64.8 nTPM
Prostate	63.8 nTPM
Pancreas	61.8 nTPM
Eye	61.5 nTPM
Liver	56.8 nTPM
Testis	49.8 nTPM
Skin	47.0 nTPM
Heart muscle	42.8 nTPM
Ovary	42.7 nTPM
Breast	39.2 nTPM
Esophagus	38.7 nTPM
Skeletal muscle	35.7 nTPM
Endometrium	34.9 nTPM
Lung	28.1 nTPM

Fibroblasts	45.1 nTPM
Prostate	83.8 nTPM
Placenta	82.1 nTPM
Breast	48.5 nTPM
Ovary	46.2 nTPM
Adipose tissue	42.2 nTPM
Heart muscle	41.8 nTPM
Skin	40.9 nTPM
Skeletal muscle	33.0 nTPM
Lung	32.4 nTPM
Esophagus	24.2 nTPM
Stomach	20.8 nTPM

Intestinal goblet cells	33.5 nTPM
Small intestine	37.1 nTPM
Rectum	33.5 nTPM
Colon	30.0 nTPM

Macrophages	33.1 nTPM
Pancreas	89.3 nTPM
Kidney	52.2 nTPM
Ovary	50.5 nTPM
Breast	40.8 nTPM
Lung	35.9 nTPM
Testis	34.9 nTPM
Prostate	32.0 nTPM
Adipose tissue	30.7 nTPM
Bone marrow	27.5 nTPM
PBMC	27.3 nTPM
Endometrium	19.5 nTPM
Skeletal muscle	18.1 nTPM
Esophagus	17.3 nTPM
Spleen	11.4 nTPM
Stomach	8.8 nTPM

Paneth cells	44.3 nTPM
Small intestine	63.8 nTPM
Colon	36.2 nTPM
Rectum	32.9 nTPM

Plasma cells	26.9 nTPM
Adipose tissue	32.2 nTPM
Spleen	31.2 nTPM
Stomach	26.8 nTPM
Esophagus	24.6 nTPM
Bone marrow	19.8 nTPM

Respiratory ciliated cells	89.0 nTPM
Bronchus	115.3 nTPM
Lung	62.7 nTPM

Smooth muscle cells	82.2 nTPM
Bronchus	365.6 nTPM
Pancreas	114.6 nTPM
Ovary	92.2 nTPM
Heart muscle	80.5 nTPM
Skin	45.3 nTPM
Prostate	43.7 nTPM
Breast	43.7 nTPM
Skeletal muscle	34.2 nTPM
Endometrium	32.7 nTPM
Adipose tissue	30.1 nTPM
Esophagus	21.7 nTPM

T-cells	52.7 nTPM
Kidney	84.9 nTPM
Adipose tissue	79.3 nTPM
Colon	71.7 nTPM
Breast	66.4 nTPM
Skin	62.7 nTPM
Liver	57.2 nTPM
Lung	56.2 nTPM
PBMC	52.9 nTPM
Esophagus	52.4 nTPM
Prostate	47.3 nTPM
Ovary	46.7 nTPM
Bone marrow	41.1 nTPM
Spleen	40.4 nTPM
Stomach	37.4 nTPM
Skeletal muscle	34.8 nTPM
Endometrium	33.1 nTPM
Lymph node	31.8 nTPM

Basal keratinocytes	51.4 nTPM
Skin	51.4 nTPM

Basal prostatic cells	59.1 nTPM
Prostate	59.1 nTPM

Basal respiratory cells	166.1 nTPM
Bronchus	166.1 nTPM

Basal squamous epithelial cells	37.5 nTPM
Esophagus	37.5 nTPM

Undifferentiated cells	36.8 nTPM
Small intestine	38.9 nTPM
Colon	37.8 nTPM
Rectum	33.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC