Single cell type - PRKCD - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRKCD
Gene descriptionⁱ Full gene name according to HGNC.	Protein kinase C delta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SK-BR-3, THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRKCD is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
OAS1	2'-5'-oligoadenylate synthetase 1	0.4953	53
KCMF1	Potassium channel modulatory factor 1	0.4734	22
SECTM1	Secreted and transmembrane 1	0.4728	53
SH3D21	SH3 domain containing 21	0.4596	25
RAC1	Rac family small GTPase 1	0.4547	22
SMCO4	Single-pass membrane protein with coiled-coil domains 4	0.4506	45
PLIN3	Perilipin 3	0.4484	53
ZNF706	Zinc finger protein 706	0.4426	25
TEP1	Telomerase associated protein 1	0.4405	14
FAM83F	Family with sequence similarity 83 member F	0.4297	25
TMEM236	Transmembrane protein 236	0.4294	45
B3GALT4	Beta-1,3-galactosyltransferase 4	0.4250	66
TRIM31	Tripartite motif containing 31	0.4229	53
IFNGR2	Interferon gamma receptor 2	0.4225	22
CASP5	Caspase 5	0.4215	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.3 nTPM
Adipose tissue	5.4 nTPM
Breast	3.2 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	23.5 nTPM
Lung	23.5 nTPM

Astrocytes	2.0 nTPM
Brain	2.0 nTPM

B-cells	25.7 nTPM
Spleen	33.9 nTPM
Lymph node	32.5 nTPM
Stomach	31.4 nTPM
Breast	28.1 nTPM
Liver	27.7 nTPM
Bone marrow	22.9 nTPM
Colon	22.3 nTPM
PBMC	20.0 nTPM
Adipose tissue	19.5 nTPM
Kidney	19.0 nTPM

Dendritic cells	24.7 nTPM
PBMC	55.8 nTPM
Adipose tissue	9.9 nTPM
Breast	8.4 nTPM

Endothelial cells	2.7 nTPM
Lung	9.3 nTPM
Eye	6.5 nTPM
Skeletal muscle	4.5 nTPM
Skin	4.2 nTPM
Breast	3.5 nTPM
Prostate	2.1 nTPM
Heart muscle	1.8 nTPM
Ovary	1.8 nTPM
Endometrium	1.4 nTPM
Esophagus	1.0 nTPM
Testis	0.9 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	6.7 nTPM
Prostate	15.4 nTPM
Skin	11.4 nTPM
Placenta	8.4 nTPM
Skeletal muscle	7.4 nTPM
Esophagus	7.2 nTPM
Stomach	6.0 nTPM
Breast	5.6 nTPM
Adipose tissue	4.8 nTPM
Heart muscle	4.0 nTPM
Ovary	2.2 nTPM
Lung	1.2 nTPM

Intestinal goblet cells	37.1 nTPM
Colon	40.7 nTPM
Small intestine	39.6 nTPM
Rectum	31.1 nTPM

Macrophages	41.5 nTPM
Bone marrow	71.2 nTPM
Stomach	64.5 nTPM
Lung	53.5 nTPM
Testis	50.6 nTPM
Adipose tissue	43.0 nTPM
PBMC	40.9 nTPM
Ovary	39.5 nTPM
Spleen	38.4 nTPM
Breast	37.2 nTPM
Kidney	36.3 nTPM
Skeletal muscle	35.8 nTPM
Endometrium	33.8 nTPM
Esophagus	33.1 nTPM
Pancreas	30.7 nTPM
Prostate	13.8 nTPM

Paneth cells	55.4 nTPM
Colon	72.5 nTPM
Small intestine	52.6 nTPM
Rectum	41.3 nTPM

Plasma cells	25.8 nTPM
Stomach	38.9 nTPM
Spleen	37.7 nTPM
Adipose tissue	21.9 nTPM
Bone marrow	18.2 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	16.5 nTPM
Lung	17.5 nTPM
Bronchus	15.5 nTPM

Smooth muscle cells	12.1 nTPM
Esophagus	27.9 nTPM
Bronchus	20.8 nTPM
Heart muscle	14.2 nTPM
Pancreas	10.9 nTPM
Skeletal muscle	10.3 nTPM
Breast	9.9 nTPM
Skin	8.7 nTPM
Prostate	8.4 nTPM
Ovary	8.4 nTPM
Adipose tissue	7.7 nTPM
Endometrium	6.2 nTPM

T-cells	10.0 nTPM
Adipose tissue	18.1 nTPM
Spleen	14.9 nTPM
Stomach	14.3 nTPM
Skin	13.8 nTPM
Breast	11.6 nTPM
Skeletal muscle	11.4 nTPM
Lymph node	11.0 nTPM
Lung	10.6 nTPM
Bone marrow	10.2 nTPM
Colon	10.0 nTPM
PBMC	8.9 nTPM
Ovary	8.9 nTPM
Endometrium	8.4 nTPM
Liver	7.1 nTPM
Esophagus	6.6 nTPM
Kidney	4.2 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	29.2 nTPM
Skin	29.2 nTPM

Basal prostatic cells	26.3 nTPM
Prostate	26.3 nTPM

Basal respiratory cells	8.0 nTPM
Bronchus	8.0 nTPM

Collecting duct cells	14.7 nTPM
Kidney	14.7 nTPM

Undifferentiated cells	23.0 nTPM
Small intestine	23.5 nTPM
Colon	22.9 nTPM
Rectum	22.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC