Single cell type - RICTOR - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RICTOR
Gene descriptionⁱ Full gene name according to HGNC.	RPTOR independent companion of MTOR complex 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RICTOR is part of cluster 9 Photoreceptor cells - Phototransduction with confidenceⁱ 1
227 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DIP2A	Disco interacting protein 2 homolog A	0.5863	63
PHC3	Polyhomeotic homolog 3	0.5685	46
NIPAL3	NIPA like domain containing 3	0.5615	52
TBC1D32	TBC1 domain family member 32	0.5466	46
EXOC4	Exocyst complex component 4	0.5167	46
RALGAPA1	Ral GTPase activating protein catalytic subunit alpha 1	0.5032	9
AAK1	AP2 associated kinase 1	0.4976	9
TNRC6C	Trinucleotide repeat containing adaptor 6C	0.4894	9
GRIPAP1	GRIP1 associated protein 1	0.4816	9
ZFP14	ZFP14 zinc finger protein	0.4795	52
USP34	Ubiquitin specific peptidase 34	0.4787	52
RBM23	RNA binding motif protein 23	0.4754	52
GLMN	Glomulin, FKBP associated protein	0.4744	46
EPG5	Ectopic P-granules autophagy protein 5 homolog	0.4690	63
PPM1B	Protein phosphatase, Mg2+/Mn2+ dependent 1B	0.4662	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.9 nTPM
Adipose tissue	46.1 nTPM
Breast	19.7 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	50.2 nTPM
Lung	50.2 nTPM

Astrocytes	72.8 nTPM
Brain	72.8 nTPM

B-cells	62.4 nTPM
Adipose tissue	94.7 nTPM
Colon	83.1 nTPM
PBMC	75.7 nTPM
Bone marrow	68.7 nTPM
Stomach	64.1 nTPM
Lymph node	62.7 nTPM
Spleen	57.8 nTPM
Kidney	52.4 nTPM
Liver	38.6 nTPM
Breast	26.8 nTPM

Dendritic cells	65.6 nTPM
Adipose tissue	110.4 nTPM
PBMC	55.8 nTPM
Breast	30.6 nTPM

Endothelial cells	43.0 nTPM
Prostate	75.2 nTPM
Heart muscle	55.5 nTPM
Skeletal muscle	54.6 nTPM
Testis	52.1 nTPM
Placenta	51.2 nTPM
Skin	50.2 nTPM
Endometrium	46.1 nTPM
Eye	39.7 nTPM
Liver	38.5 nTPM
Esophagus	35.0 nTPM
Ovary	31.7 nTPM
Lung	24.9 nTPM
Breast	24.1 nTPM
Pancreas	23.1 nTPM

Fibroblasts	37.4 nTPM
Prostate	57.2 nTPM
Adipose tissue	54.3 nTPM
Skin	46.5 nTPM
Placenta	45.6 nTPM
Lung	42.4 nTPM
Skeletal muscle	41.1 nTPM
Esophagus	34.3 nTPM
Heart muscle	28.8 nTPM
Stomach	25.3 nTPM
Breast	20.6 nTPM
Ovary	15.4 nTPM

Intestinal goblet cells	26.0 nTPM
Small intestine	30.7 nTPM
Rectum	29.4 nTPM
Colon	17.9 nTPM

Macrophages	36.3 nTPM
Spleen	55.0 nTPM
Testis	52.3 nTPM
Prostate	51.6 nTPM
Kidney	50.6 nTPM
Bone marrow	48.7 nTPM
Pancreas	43.4 nTPM
Adipose tissue	42.7 nTPM
Skeletal muscle	38.2 nTPM
Ovary	33.1 nTPM
Lung	32.1 nTPM
Endometrium	31.8 nTPM
Esophagus	28.3 nTPM
Breast	19.9 nTPM
Stomach	17.6 nTPM
PBMC	0.0 nTPM

Paneth cells	29.9 nTPM
Small intestine	45.0 nTPM
Rectum	25.0 nTPM
Colon	19.7 nTPM

Plasma cells	48.7 nTPM
Adipose tissue	107.7 nTPM
Stomach	45.0 nTPM
Esophagus	36.9 nTPM
Bone marrow	33.0 nTPM
Spleen	21.1 nTPM

Respiratory ciliated cells	38.0 nTPM
Bronchus	59.9 nTPM
Lung	16.0 nTPM

Smooth muscle cells	34.6 nTPM
Skeletal muscle	66.9 nTPM
Prostate	64.4 nTPM
Bronchus	44.3 nTPM
Adipose tissue	41.9 nTPM
Skin	32.7 nTPM
Ovary	27.4 nTPM
Endometrium	27.3 nTPM
Heart muscle	23.6 nTPM
Esophagus	23.3 nTPM
Breast	15.5 nTPM
Pancreas	13.5 nTPM

T-cells	70.9 nTPM
Adipose tissue	112.4 nTPM
Colon	97.9 nTPM
Liver	97.3 nTPM
Skeletal muscle	87.5 nTPM
PBMC	87.1 nTPM
Skin	84.3 nTPM
Endometrium	72.6 nTPM
Bone marrow	69.5 nTPM
Ovary	66.8 nTPM
Prostate	66.3 nTPM
Lymph node	61.3 nTPM
Kidney	57.5 nTPM
Spleen	54.5 nTPM
Esophagus	52.4 nTPM
Stomach	51.8 nTPM
Lung	45.6 nTPM
Breast	39.9 nTPM

Basal keratinocytes	48.8 nTPM
Skin	48.8 nTPM

Basal prostatic cells	39.6 nTPM
Prostate	39.6 nTPM

Basal respiratory cells	38.7 nTPM
Bronchus	38.7 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Undifferentiated cells	19.6 nTPM
Rectum	25.6 nTPM
Small intestine	20.1 nTPM
Colon	13.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC