Single cell type - PRDX3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRDX3
Gene descriptionⁱ Full gene name according to HGNC.	Peroxiredoxin 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells, Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells, Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRDX3 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SDHC	Succinate dehydrogenase complex subunit C	0.7498	67
MRPS35	Mitochondrial ribosomal protein S35	0.7431	39
MOCS2	Molybdenum cofactor synthesis 2	0.7413	39
MCCD1	Mitochondrial coiled-coil domain 1	0.7404	67
COA3	Cytochrome c oxidase assembly factor 3	0.7156	67
ANAPC13	Anaphase promoting complex subunit 13	0.7151	67
HIBADH	3-hydroxyisobutyrate dehydrogenase	0.6862	39
LDHB	Lactate dehydrogenase B	0.6803	39
FXYD2	FXYD domain containing ion transport regulator 2	0.6786	67
ETFRF1	Electron transfer flavoprotein regulatory factor 1	0.6776	7
FXYD6-FXYD2	FXYD6-FXYD2 readthrough	0.6762	39
POU3F3	POU class 3 homeobox 3	0.6609	67
MCAT	Malonyl-CoA-acyl carrier protein transacylase	0.6600	67
MRPL19	Mitochondrial ribosomal protein L19	0.6575	39
RPA3	Replication protein A3	0.6544	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	61.4 nTPM
Breast	65.5 nTPM
Adipose tissue	57.3 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	74.5 nTPM
Lung	74.5 nTPM

Astrocytes	14.4 nTPM
Brain	14.4 nTPM

B-cells	65.1 nTPM
Liver	145.8 nTPM
Kidney	95.3 nTPM
Spleen	85.5 nTPM
Bone marrow	58.9 nTPM
Colon	57.5 nTPM
Stomach	57.2 nTPM
PBMC	49.9 nTPM
Lymph node	40.3 nTPM
Breast	38.8 nTPM
Adipose tissue	21.6 nTPM

Dendritic cells	50.6 nTPM
PBMC	99.6 nTPM
Breast	28.8 nTPM
Adipose tissue	23.5 nTPM

Endothelial cells	78.3 nTPM
Placenta	105.1 nTPM
Liver	97.3 nTPM
Testis	91.5 nTPM
Ovary	89.7 nTPM
Heart muscle	88.1 nTPM
Esophagus	83.9 nTPM
Pancreas	81.1 nTPM
Skin	80.7 nTPM
Breast	79.2 nTPM
Prostate	73.6 nTPM
Eye	66.3 nTPM
Endometrium	62.2 nTPM
Skeletal muscle	54.2 nTPM
Lung	43.7 nTPM

Enteroendocrine cells	110.9 nTPM
Rectum	111.6 nTPM
Colon	110.1 nTPM

Erythroid cells	132.8 nTPM
Bone marrow	148.0 nTPM
Liver	117.5 nTPM

Fibroblasts	100.8 nTPM
Placenta	194.2 nTPM
Heart muscle	137.0 nTPM
Ovary	135.7 nTPM
Esophagus	101.2 nTPM
Skin	91.0 nTPM
Adipose tissue	87.0 nTPM
Stomach	86.1 nTPM
Lung	74.8 nTPM
Breast	74.4 nTPM
Prostate	70.8 nTPM
Skeletal muscle	57.2 nTPM

Intestinal goblet cells	132.5 nTPM
Rectum	136.0 nTPM
Small intestine	132.8 nTPM
Colon	128.6 nTPM

Macrophages	127.9 nTPM
Spleen	236.4 nTPM
Kidney	206.4 nTPM
Bone marrow	179.9 nTPM
Stomach	167.0 nTPM
Esophagus	148.0 nTPM
Pancreas	145.5 nTPM
Ovary	143.6 nTPM
Prostate	129.6 nTPM
Testis	117.3 nTPM
Lung	114.5 nTPM
Adipose tissue	97.8 nTPM
Endometrium	83.7 nTPM
Skeletal muscle	82.1 nTPM
Breast	66.8 nTPM
PBMC	0.0 nTPM

Paneth cells	99.3 nTPM
Rectum	146.8 nTPM
Small intestine	105.1 nTPM
Colon	46.1 nTPM

Plasma cells	153.7 nTPM
Spleen	289.4 nTPM
Bone marrow	238.9 nTPM
Stomach	131.2 nTPM
Esophagus	92.4 nTPM
Adipose tissue	16.7 nTPM

Respiratory ciliated cells	163.4 nTPM
Bronchus	213.2 nTPM
Lung	113.7 nTPM

Basal keratinocytes	69.8 nTPM
Skin	69.8 nTPM

Basal prostatic cells	117.8 nTPM
Prostate	117.8 nTPM

Basal respiratory cells	274.0 nTPM
Bronchus	274.0 nTPM

Basal squamous epithelial cells	81.4 nTPM
Esophagus	81.4 nTPM

Smooth muscle cells	105.3 nTPM
Heart muscle	223.8 nTPM
Esophagus	139.5 nTPM
Pancreas	136.8 nTPM
Ovary	113.2 nTPM
Skin	109.5 nTPM
Breast	80.6 nTPM
Bronchus	79.8 nTPM
Prostate	78.8 nTPM
Adipose tissue	76.3 nTPM
Skeletal muscle	64.0 nTPM
Endometrium	55.8 nTPM

T-cells	56.1 nTPM
Kidney	142.3 nTPM
Spleen	85.0 nTPM
Stomach	81.6 nTPM
Bone marrow	75.0 nTPM
Skin	63.0 nTPM
Esophagus	58.9 nTPM
Liver	56.2 nTPM
Ovary	53.4 nTPM
Lymph node	51.5 nTPM
PBMC	50.5 nTPM
Colon	47.1 nTPM
Lung	47.1 nTPM
Breast	32.7 nTPM
Endometrium	29.8 nTPM
Prostate	28.4 nTPM
Skeletal muscle	27.6 nTPM
Adipose tissue	24.0 nTPM

Undifferentiated cells	207.0 nTPM
Colon	222.5 nTPM
Small intestine	221.8 nTPM
Rectum	176.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC