Single cell type - SDHC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SDHC
Gene descriptionⁱ Full gene name according to HGNC.	Succinate dehydrogenase complex subunit C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Citric acid cycle related proteins Disease related genes Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SDHC is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MCCD1	Mitochondrial coiled-coil domain 1	0.8019	67
PRDX3	Peroxiredoxin 3	0.7498	39
NIT2	Nitrilase family member 2	0.7253	67
HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase	0.7159	67
MAJIN	Membrane anchored junction protein	0.6987	67
BBOX1	Gamma-butyrobetaine hydroxylase 1	0.6961	67
BDH2	3-hydroxybutyrate dehydrogenase 2	0.6946	67
C1D	C1D nuclear receptor corepressor	0.6924	39
LYG1	Lysozyme g1	0.6841	67
SUCLG1	Succinate-CoA ligase GDP/ADP-forming subunit alpha	0.6833	67
LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	0.6831	67
C11orf54	Chromosome 11 open reading frame 54	0.6806	67
ACAT1	Acetyl-CoA acetyltransferase 1	0.6798	67
MIOX	Myo-inositol oxygenase	0.6796	67
WEE2	WEE2 oocyte meiosis inhibiting kinase	0.6767	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	50.9 nTPM
Breast	53.0 nTPM
Adipose tissue	48.8 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	59.4 nTPM
Lung	59.4 nTPM

Astrocytes	14.7 nTPM
Brain	14.7 nTPM

B-cells	70.1 nTPM
Liver	121.9 nTPM
Kidney	104.8 nTPM
PBMC	89.9 nTPM
Colon	76.7 nTPM
Stomach	68.1 nTPM
Spleen	63.7 nTPM
Bone marrow	61.3 nTPM
Lymph node	57.1 nTPM
Breast	29.4 nTPM
Adipose tissue	27.6 nTPM

Dendritic cells	65.5 nTPM
PBMC	107.6 nTPM
Breast	52.5 nTPM
Adipose tissue	36.4 nTPM

Endothelial cells	80.7 nTPM
Pancreas	216.2 nTPM
Placenta	133.6 nTPM
Testis	94.5 nTPM
Prostate	82.9 nTPM
Ovary	80.8 nTPM
Skin	72.9 nTPM
Esophagus	71.3 nTPM
Eye	67.2 nTPM
Breast	63.3 nTPM
Skeletal muscle	60.3 nTPM
Liver	59.6 nTPM
Endometrium	49.2 nTPM
Lung	40.6 nTPM
Heart muscle	36.7 nTPM

Fibroblasts	79.8 nTPM
Placenta	139.1 nTPM
Ovary	115.7 nTPM
Stomach	89.1 nTPM
Esophagus	79.8 nTPM
Adipose tissue	73.9 nTPM
Prostate	69.6 nTPM
Lung	68.2 nTPM
Breast	64.0 nTPM
Skin	63.6 nTPM
Skeletal muscle	61.5 nTPM
Heart muscle	52.8 nTPM

Intestinal goblet cells	103.4 nTPM
Colon	112.2 nTPM
Rectum	111.6 nTPM
Small intestine	86.5 nTPM

Macrophages	94.6 nTPM
Pancreas	239.9 nTPM
Kidney	158.8 nTPM
Stomach	111.3 nTPM
Prostate	104.3 nTPM
Testis	103.9 nTPM
Spleen	86.0 nTPM
Ovary	85.3 nTPM
PBMC	81.8 nTPM
Bone marrow	81.2 nTPM
Lung	72.6 nTPM
Esophagus	62.9 nTPM
Breast	60.4 nTPM
Adipose tissue	58.5 nTPM
Endometrium	56.7 nTPM
Skeletal muscle	55.7 nTPM

Paneth cells	89.5 nTPM
Rectum	132.9 nTPM
Small intestine	112.7 nTPM
Colon	23.1 nTPM

Plasma cells	71.9 nTPM
Spleen	108.3 nTPM
Stomach	93.1 nTPM
Bone marrow	90.6 nTPM
Esophagus	43.0 nTPM
Adipose tissue	24.5 nTPM

Respiratory ciliated cells	177.9 nTPM
Bronchus	249.3 nTPM
Lung	106.4 nTPM

Smooth muscle cells	94.4 nTPM
Pancreas	204.4 nTPM
Bronchus	119.8 nTPM
Prostate	103.4 nTPM
Esophagus	102.3 nTPM
Ovary	100.7 nTPM
Skeletal muscle	83.3 nTPM
Skin	80.2 nTPM
Breast	71.8 nTPM
Heart muscle	64.8 nTPM
Adipose tissue	59.7 nTPM
Endometrium	48.0 nTPM

T-cells	72.0 nTPM
Kidney	161.6 nTPM
PBMC	98.4 nTPM
Stomach	97.0 nTPM
Liver	96.2 nTPM
Colon	88.4 nTPM
Bone marrow	79.9 nTPM
Prostate	71.1 nTPM
Spleen	70.1 nTPM
Skin	69.6 nTPM
Ovary	66.8 nTPM
Esophagus	65.5 nTPM
Lymph node	58.2 nTPM
Skeletal muscle	48.0 nTPM
Breast	42.2 nTPM
Lung	41.0 nTPM
Adipose tissue	39.4 nTPM
Endometrium	29.9 nTPM

Basal keratinocytes	61.8 nTPM
Skin	61.8 nTPM

Basal prostatic cells	151.2 nTPM
Prostate	151.2 nTPM

Basal respiratory cells	342.6 nTPM
Bronchus	342.6 nTPM

Cholangiocytes	131.5 nTPM
Liver	131.5 nTPM

Undifferentiated cells	154.2 nTPM
Colon	163.1 nTPM
Small intestine	157.0 nTPM
Rectum	142.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC