Single cell type - POLL - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLL
Gene descriptionⁱ Full gene name according to HGNC.	DNA polymerase lambda
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

POLL is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 1
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
XRRA1	X-ray radiation resistance associated 1	0.5995	9
CYB5D2	Cytochrome b5 domain containing 2	0.5021	66
SLC22A16	Solute carrier family 22 member 16	0.4939	6
CATSPER2	Cation channel sperm associated 2	0.4930	9
NEU3	Neuraminidase 3	0.4875	9
ZNF689	Zinc finger protein 689	0.4862	66
C3orf62	Chromosome 3 open reading frame 62	0.4795	66
TTI2	TELO2 interacting protein 2	0.4765	66
ZNF692	Zinc finger protein 692	0.4736	66
AARD	Alanine and arginine rich domain containing protein	0.4731	66
RMND5B	Required for meiotic nuclear division 5 homolog B	0.4676	25
SIGLECL1	SIGLEC family like 1	0.4641	66
CINP	Cyclin dependent kinase 2 interacting protein	0.4629	66
POU5F2	POU domain class 5, transcription factor 2	0.4544	66
MRPL43	Mitochondrial ribosomal protein L43	0.4486	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.5 nTPM
Breast	8.7 nTPM
Adipose tissue	6.4 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	12.9 nTPM
Lung	12.9 nTPM

Astrocytes	13.7 nTPM
Brain	13.7 nTPM

B-cells	11.4 nTPM
Liver	20.2 nTPM
Colon	19.2 nTPM
PBMC	12.9 nTPM
Spleen	12.8 nTPM
Stomach	10.9 nTPM
Lymph node	9.9 nTPM
Kidney	9.5 nTPM
Adipose tissue	7.0 nTPM
Bone marrow	6.6 nTPM
Breast	5.3 nTPM

Dendritic cells	7.5 nTPM
PBMC	8.0 nTPM
Breast	7.2 nTPM
Adipose tissue	7.1 nTPM

Endothelial cells	7.6 nTPM
Breast	12.8 nTPM
Liver	11.9 nTPM
Testis	10.9 nTPM
Ovary	10.1 nTPM
Eye	8.9 nTPM
Esophagus	8.8 nTPM
Placenta	8.0 nTPM
Skeletal muscle	7.8 nTPM
Endometrium	6.7 nTPM
Heart muscle	6.5 nTPM
Skin	6.3 nTPM
Pancreas	3.9 nTPM
Prostate	3.7 nTPM
Lung	0.0 nTPM

Fibroblasts	9.6 nTPM
Esophagus	13.9 nTPM
Ovary	12.9 nTPM
Adipose tissue	12.8 nTPM
Breast	12.1 nTPM
Skeletal muscle	10.8 nTPM
Placenta	10.1 nTPM
Stomach	8.9 nTPM
Skin	7.3 nTPM
Lung	6.7 nTPM
Prostate	5.5 nTPM
Heart muscle	5.0 nTPM

Intestinal goblet cells	13.6 nTPM
Rectum	15.4 nTPM
Small intestine	13.1 nTPM
Colon	12.1 nTPM

Macrophages	9.6 nTPM
Ovary	17.6 nTPM
Testis	15.7 nTPM
Pancreas	12.8 nTPM
Adipose tissue	11.1 nTPM
Breast	10.8 nTPM
Spleen	10.4 nTPM
Bone marrow	10.0 nTPM
Kidney	9.9 nTPM
Esophagus	9.4 nTPM
Skeletal muscle	9.3 nTPM
Prostate	8.1 nTPM
Lung	7.6 nTPM
Endometrium	6.2 nTPM
Stomach	5.9 nTPM
PBMC	0.0 nTPM

Paneth cells	9.2 nTPM
Rectum	13.4 nTPM
Small intestine	7.5 nTPM
Colon	6.5 nTPM

Plasma cells	10.9 nTPM
Stomach	18.1 nTPM
Esophagus	12.3 nTPM
Spleen	11.7 nTPM
Bone marrow	6.6 nTPM
Adipose tissue	5.8 nTPM

Respiratory ciliated cells	7.2 nTPM
Bronchus	9.9 nTPM
Lung	4.4 nTPM

Smooth muscle cells	9.6 nTPM
Breast	16.2 nTPM
Esophagus	15.5 nTPM
Prostate	11.2 nTPM
Skeletal muscle	10.6 nTPM
Adipose tissue	10.6 nTPM
Ovary	10.5 nTPM
Pancreas	8.3 nTPM
Endometrium	6.4 nTPM
Skin	5.9 nTPM
Heart muscle	5.6 nTPM
Bronchus	4.6 nTPM

T-cells	9.4 nTPM
Liver	17.0 nTPM
PBMC	16.6 nTPM
Kidney	13.7 nTPM
Ovary	13.4 nTPM
Lymph node	11.9 nTPM
Bone marrow	11.4 nTPM
Spleen	10.8 nTPM
Skeletal muscle	10.7 nTPM
Breast	10.7 nTPM
Colon	10.5 nTPM
Adipose tissue	8.7 nTPM
Stomach	8.5 nTPM
Endometrium	5.9 nTPM
Skin	5.5 nTPM
Prostate	4.7 nTPM
Lung	0.0 nTPM
Esophagus	0.0 nTPM

Basal respiratory cells	9.7 nTPM
Bronchus	9.7 nTPM

Basal squamous epithelial cells	7.4 nTPM
Esophagus	7.4 nTPM

Cholangiocytes	11.5 nTPM
Liver	11.5 nTPM

Cone photoreceptor cells	47.9 nTPM
Eye	47.9 nTPM

Undifferentiated cells	15.6 nTPM
Small intestine	17.6 nTPM
Rectum	15.9 nTPM
Colon	13.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC