Single cell type - AXL - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AXL
Gene descriptionⁱ Full gene name according to HGNC.	AXL receptor tyrosine kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Sertoli cells, Kupffer cells, Langerhans cells, Smooth muscle cells, Fibroblasts, Prostatic glandular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (plasmacytoid DC, NK-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (fHDF/TERT166, U-251 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Sertoli cells, Kupffer cells, Langerhans cells, Smooth muscle cells, Fibroblasts, Prostatic glandular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AXL is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCL26	C-C motif chemokine ligand 26	0.8482	48
TBX18	T-box transcription factor 18	0.8229	48
GEM	GTP binding protein overexpressed in skeletal muscle	0.7858	48
CRISPLD2	Cysteine rich secretory protein LCCL domain containing 2	0.7856	48
CCL19	C-C motif chemokine ligand 19	0.7583	48
VASN	Vasorin	0.7547	48
KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4	0.7462	48
CYP26B1	Cytochrome P450 family 26 subfamily B member 1	0.7164	48
HAS2	Hyaluronan synthase 2	0.7150	50
WTAP	WT1 associated protein	0.7134	48
C11orf96	Chromosome 11 open reading frame 96	0.7101	48
MRGPRF	MAS related GPR family member F	0.7081	48
CCL8	C-C motif chemokine ligand 8	0.6869	48
COCH	Cochlin	0.6835	48
HOXC8	Homeobox C8	0.6835	33

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	13.5 nTPM
Breast	16.4 nTPM
Adipose tissue	10.6 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	3.6 nTPM
Lung	3.6 nTPM

Astrocytes	35.9 nTPM
Brain	35.9 nTPM

B-cells	1.9 nTPM
Colon	16.0 nTPM
Breast	2.6 nTPM
Liver	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Dendritic cells	0.8 nTPM
Breast	1.5 nTPM
Adipose tissue	1.0 nTPM
PBMC	0.0 nTPM

Endothelial cells	17.7 nTPM
Eye	103.6 nTPM
Skin	45.9 nTPM
Prostate	39.7 nTPM
Breast	21.2 nTPM
Skeletal muscle	17.9 nTPM
Testis	5.7 nTPM
Endometrium	5.5 nTPM
Placenta	2.9 nTPM
Heart muscle	2.6 nTPM
Ovary	1.7 nTPM
Esophagus	1.5 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	147.2 nTPM
Skin	535.7 nTPM
Prostate	320.3 nTPM
Adipose tissue	222.5 nTPM
Skeletal muscle	162.2 nTPM
Breast	135.1 nTPM
Placenta	85.1 nTPM
Heart muscle	44.3 nTPM
Stomach	40.1 nTPM
Esophagus	39.0 nTPM
Lung	19.0 nTPM
Ovary	15.9 nTPM

Intestinal goblet cells	0.1 nTPM
Small intestine	0.4 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	61.4 nTPM
Prostate	337.0 nTPM
Breast	143.8 nTPM
Ovary	114.0 nTPM
Endometrium	63.6 nTPM
Adipose tissue	57.6 nTPM
Esophagus	55.1 nTPM
Lung	46.8 nTPM
Testis	43.0 nTPM
Skeletal muscle	26.3 nTPM
Spleen	14.5 nTPM
Kidney	11.4 nTPM
Stomach	2.9 nTPM
Pancreas	2.5 nTPM
Bone marrow	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	0.8 nTPM
Bone marrow	1.7 nTPM
Adipose tissue	1.3 nTPM
Stomach	0.9 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	2.8 nTPM
Lung	4.4 nTPM
Bronchus	1.3 nTPM

Smooth muscle cells	171.1 nTPM
Skin	587.8 nTPM
Prostate	405.7 nTPM
Skeletal muscle	206.1 nTPM
Adipose tissue	156.6 nTPM
Ovary	125.7 nTPM
Pancreas	112.9 nTPM
Breast	99.7 nTPM
Endometrium	81.0 nTPM
Heart muscle	63.7 nTPM
Esophagus	40.3 nTPM
Bronchus	2.9 nTPM

T-cells	3.6 nTPM
Skin	32.6 nTPM
Esophagus	6.6 nTPM
Prostate	4.7 nTPM
Skeletal muscle	4.4 nTPM
Endometrium	3.9 nTPM
Lung	3.0 nTPM
Breast	1.8 nTPM
Adipose tissue	1.1 nTPM
Liver	0.9 nTPM
Colon	0.5 nTPM
Stomach	0.4 nTPM
PBMC	0.3 nTPM
Spleen	0.2 nTPM
Bone marrow	0.1 nTPM
Kidney	0.0 nTPM
Ovary	0.0 nTPM
Lymph node	0.0 nTPM

Basal keratinocytes	41.7 nTPM
Skin	41.7 nTPM

Basal prostatic cells	88.3 nTPM
Prostate	88.3 nTPM

Basal respiratory cells	10.3 nTPM
Bronchus	10.3 nTPM

Basal squamous epithelial cells	3.4 nTPM
Esophagus	3.4 nTPM

Undifferentiated cells	0.1 nTPM
Rectum	0.1 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC