Single cell type - HAS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HAS2
Gene descriptionⁱ Full gene name according to HGNC.	Hyaluronan synthase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Fibroblasts, Basal prostatic cells, Smooth muscle cells, Melanocytes, Langerhans cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (HBF TERT88, hTEC/SVTERT24-B, LHCN-M2, U-138 MG, U-251 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Fibroblasts, Basal prostatic cells, Smooth muscle cells, Melanocytes, Langerhans cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HAS2 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM180A	Family with sequence similarity 180 member A	0.8376	50
FAM180B	Family with sequence similarity 180 member B	0.8164	50
HAS1	Hyaluronan synthase 1	0.8076	50
TNFAIP6	TNF alpha induced protein 6	0.7964	50
SFRP2	Secreted frizzled related protein 2	0.7846	50
MATN4	Matrilin 4	0.7769	50
ELANE	Elastase, neutrophil expressed	0.7624	50
MEDAG	Mesenteric estrogen dependent adipogenesis	0.7564	50
THBS2	Thrombospondin 2	0.7520	50
ANGPTL5	Angiopoietin like 5	0.7413	50
MXRA5	Matrix remodeling associated 5	0.7327	50
MMP27	Matrix metallopeptidase 27	0.7304	50
ASPN	Asporin	0.7234	50
FGFR1	Fibroblast growth factor receptor 1	0.7176	50
AXL	AXL receptor tyrosine kinase	0.7150	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.2 nTPM
Adipose tissue	3.2 nTPM
Breast	1.3 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	0.0 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	0.2 nTPM
Adipose tissue	0.6 nTPM
PBMC	0.0 nTPM
Breast	0.0 nTPM

Endothelial cells	7.2 nTPM
Lung	28.1 nTPM
Skin	27.9 nTPM
Esophagus	15.5 nTPM
Prostate	6.7 nTPM
Heart muscle	6.4 nTPM
Endometrium	5.5 nTPM
Breast	3.9 nTPM
Liver	3.7 nTPM
Skeletal muscle	2.8 nTPM
Eye	0.0 nTPM
Placenta	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM

Fibroblasts	62.1 nTPM
Skin	214.5 nTPM
Skeletal muscle	108.6 nTPM
Adipose tissue	89.2 nTPM
Esophagus	72.8 nTPM
Heart muscle	66.0 nTPM
Stomach	49.0 nTPM
Lung	38.0 nTPM
Breast	24.4 nTPM
Prostate	14.8 nTPM
Placenta	6.1 nTPM
Ovary	0.2 nTPM

Intestinal goblet cells	2.3 nTPM
Rectum	5.5 nTPM
Colon	1.4 nTPM
Small intestine	0.0 nTPM

Macrophages	0.7 nTPM
Skeletal muscle	3.9 nTPM
Prostate	3.4 nTPM
Esophagus	1.6 nTPM
Lung	1.4 nTPM
Endometrium	0.4 nTPM
Adipose tissue	0.2 nTPM
Breast	0.2 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	1.9 nTPM
Rectum	5.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	0.0 nTPM
Lung	0.0 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	30.7 nTPM
Pancreas	209.9 nTPM
Skin	72.4 nTPM
Adipose tissue	18.6 nTPM
Skeletal muscle	13.0 nTPM
Esophagus	9.3 nTPM
Endometrium	7.8 nTPM
Breast	3.2 nTPM
Prostate	2.8 nTPM
Heart muscle	0.8 nTPM
Ovary	0.2 nTPM
Bronchus	0.0 nTPM

T-cells	1.5 nTPM
Skin	18.0 nTPM
Prostate	4.7 nTPM
Skeletal muscle	2.3 nTPM
Liver	0.6 nTPM
Endometrium	0.3 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Lung	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Early spermatids	19.0 nTPM
Testis	19.0 nTPM

Endometrial stromal cells	3.5 nTPM
Endometrium	3.5 nTPM

Excitatory neurons	0.1 nTPM
Brain	0.1 nTPM

Undifferentiated cells	3.9 nTPM
Rectum	10.7 nTPM
Colon	1.0 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC