Single cell type - NDUFS5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFS5
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit S5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFS5 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NDUFA4	NDUFA4 mitochondrial complex associated	0.8092	39
PDHA1	Pyruvate dehydrogenase E1 subunit alpha 1	0.7649	39
NDUFB2	NADH:ubiquinone oxidoreductase subunit B2	0.7514	39
UQCRB	Ubiquinol-cytochrome c reductase binding protein	0.7450	39
BOLA3	BolA family member 3	0.7389	39
NDUFC1	NADH:ubiquinone oxidoreductase subunit C1	0.7333	39
NDUFA1	NADH:ubiquinone oxidoreductase subunit A1	0.7308	39
MDH1	Malate dehydrogenase 1	0.7285	39
UQCRFS1	Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.7248	39
UQCR10	Ubiquinol-cytochrome c reductase, complex III subunit X	0.7195	39
MRPS33	Mitochondrial ribosomal protein S33	0.7167	39
COX7B	Cytochrome c oxidase subunit 7B	0.7111	39
MRPL33	Mitochondrial ribosomal protein L33	0.6989	54
NDUFB3	NADH:ubiquinone oxidoreductase subunit B3	0.6970	39
COX6B1	Cytochrome c oxidase subunit 6B1	0.6871	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	260.1 nTPM
Breast	291.5 nTPM
Adipose tissue	228.8 nTPM

Alveolar cells type 1	166.7 nTPM
Lung	166.7 nTPM

Alveolar cells type 2	196.0 nTPM
Lung	196.0 nTPM

Astrocytes	16.6 nTPM
Brain	16.6 nTPM

B-cells	197.1 nTPM
Liver	540.5 nTPM
Kidney	271.3 nTPM
Colon	263.6 nTPM
Breast	175.2 nTPM
PBMC	167.0 nTPM
Adipose tissue	158.4 nTPM
Spleen	115.2 nTPM
Stomach	114.9 nTPM
Bone marrow	103.8 nTPM
Lymph node	61.1 nTPM

Basal squamous epithelial cells	187.2 nTPM
Esophagus	187.2 nTPM

Dendritic cells	248.2 nTPM
Adipose tissue	312.6 nTPM
PBMC	223.2 nTPM
Breast	208.8 nTPM

Endothelial cells	288.4 nTPM
Pancreas	374.5 nTPM
Heart muscle	372.5 nTPM
Placenta	368.3 nTPM
Skin	349.4 nTPM
Prostate	349.1 nTPM
Liver	333.8 nTPM
Testis	332.2 nTPM
Endometrium	295.7 nTPM
Breast	282.6 nTPM
Ovary	258.9 nTPM
Skeletal muscle	218.1 nTPM
Lung	190.3 nTPM
Eye	176.4 nTPM
Esophagus	136.1 nTPM

Enteroendocrine cells	407.8 nTPM
Rectum	424.7 nTPM
Colon	390.8 nTPM

Erythroid cells	230.8 nTPM
Liver	235.4 nTPM
Bone marrow	226.1 nTPM

Fibroblasts	377.8 nTPM
Heart muscle	744.6 nTPM
Placenta	487.4 nTPM
Prostate	456.1 nTPM
Ovary	425.8 nTPM
Skin	410.2 nTPM
Adipose tissue	399.9 nTPM
Lung	326.2 nTPM
Breast	308.7 nTPM
Skeletal muscle	239.0 nTPM
Esophagus	190.1 nTPM
Stomach	167.8 nTPM

Intestinal goblet cells	652.0 nTPM
Colon	952.0 nTPM
Rectum	697.4 nTPM
Small intestine	306.6 nTPM

Macrophages	297.5 nTPM
Kidney	625.4 nTPM
PBMC	586.5 nTPM
Pancreas	528.3 nTPM
Lung	321.9 nTPM
Endometrium	312.0 nTPM
Ovary	299.4 nTPM
Testis	275.9 nTPM
Prostate	240.8 nTPM
Adipose tissue	230.7 nTPM
Breast	204.6 nTPM
Skeletal muscle	175.6 nTPM
Spleen	175.2 nTPM
Esophagus	169.9 nTPM
Stomach	158.2 nTPM
Bone marrow	157.4 nTPM

Paneth cells	517.7 nTPM
Colon	632.4 nTPM
Rectum	590.3 nTPM
Small intestine	330.4 nTPM

Plasma cells	247.6 nTPM
Spleen	395.0 nTPM
Bone marrow	316.4 nTPM
Stomach	216.8 nTPM
Esophagus	160.2 nTPM
Adipose tissue	149.6 nTPM

Cholangiocytes	391.7 nTPM
Liver	391.7 nTPM

Collecting duct cells	551.8 nTPM
Kidney	551.8 nTPM

Cone photoreceptor cells	37.5 nTPM
Eye	37.5 nTPM

Cytotrophoblasts	638.9 nTPM
Placenta	638.9 nTPM

Respiratory ciliated cells	343.3 nTPM
Bronchus	393.6 nTPM
Lung	293.0 nTPM

Smooth muscle cells	450.5 nTPM
Pancreas	755.5 nTPM
Ovary	663.9 nTPM
Heart muscle	576.4 nTPM
Skin	527.3 nTPM
Prostate	507.3 nTPM
Endometrium	426.7 nTPM
Adipose tissue	369.7 nTPM
Breast	362.8 nTPM
Skeletal muscle	353.4 nTPM
Esophagus	218.7 nTPM
Bronchus	193.3 nTPM

T-cells	292.2 nTPM
Skin	576.1 nTPM
Adipose tissue	454.8 nTPM
Colon	409.1 nTPM
PBMC	402.7 nTPM
Kidney	401.8 nTPM
Breast	341.5 nTPM
Endometrium	294.7 nTPM
Prostate	284.0 nTPM
Liver	273.4 nTPM
Stomach	258.4 nTPM
Skeletal muscle	250.0 nTPM
Spleen	242.8 nTPM
Lung	189.9 nTPM
Ovary	184.7 nTPM
Bone marrow	150.8 nTPM
Lymph node	141.1 nTPM
Esophagus	111.4 nTPM

Undifferentiated cells	697.1 nTPM
Colon	890.4 nTPM
Rectum	760.6 nTPM
Small intestine	440.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC