Single cell type - UQCRFS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UQCRFS1
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UQCRFS1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DLD	Dihydrolipoamide dehydrogenase	0.8293	39
PDHA1	Pyruvate dehydrogenase E1 subunit alpha 1	0.8073	39
NDUFC1	NADH:ubiquinone oxidoreductase subunit C1	0.7806	39
UQCR10	Ubiquinol-cytochrome c reductase, complex III subunit X	0.7687	39
NDUFB5	NADH:ubiquinone oxidoreductase subunit B5	0.7603	39
MDH1	Malate dehydrogenase 1	0.7533	39
NDUFB3	NADH:ubiquinone oxidoreductase subunit B3	0.7506	39
MPC1	Mitochondrial pyruvate carrier 1	0.7463	39
NDUFA4	NDUFA4 mitochondrial complex associated	0.7343	39
COX7B	Cytochrome c oxidase subunit 7B	0.7264	39
MRPS33	Mitochondrial ribosomal protein S33	0.7256	39
NDUFS5	NADH:ubiquinone oxidoreductase subunit S5	0.7248	39
NDUFB2	NADH:ubiquinone oxidoreductase subunit B2	0.7224	39
NDUFA10	NADH:ubiquinone oxidoreductase subunit A10	0.7154	39
NDUFA5	NADH:ubiquinone oxidoreductase subunit A5	0.7106	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	69.7 nTPM
Breast	81.0 nTPM
Adipose tissue	58.4 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Alveolar cells type 2	46.6 nTPM
Lung	46.6 nTPM

Astrocytes	16.6 nTPM
Brain	16.6 nTPM

B-cells	104.9 nTPM
Liver	250.9 nTPM
Stomach	130.3 nTPM
Colon	111.8 nTPM
Adipose tissue	104.3 nTPM
Spleen	95.5 nTPM
PBMC	91.3 nTPM
Bone marrow	75.2 nTPM
Breast	72.2 nTPM
Kidney	66.6 nTPM
Lymph node	51.2 nTPM

Basal squamous epithelial cells	105.9 nTPM
Esophagus	105.9 nTPM

Dendritic cells	116.8 nTPM
Adipose tissue	154.7 nTPM
PBMC	103.6 nTPM
Breast	92.2 nTPM

Endothelial cells	106.8 nTPM
Heart muscle	261.2 nTPM
Prostate	175.9 nTPM
Placenta	157.5 nTPM
Pancreas	154.4 nTPM
Liver	95.4 nTPM
Ovary	88.9 nTPM
Breast	88.9 nTPM
Testis	87.1 nTPM
Skin	78.7 nTPM
Eye	72.8 nTPM
Skeletal muscle	70.0 nTPM
Endometrium	62.4 nTPM
Esophagus	52.1 nTPM
Lung	49.9 nTPM

Enteroendocrine cells	160.0 nTPM
Rectum	160.1 nTPM
Colon	159.9 nTPM

Erythroid cells	147.9 nTPM
Liver	160.4 nTPM
Bone marrow	135.4 nTPM

Fibroblasts	126.7 nTPM
Heart muscle	373.5 nTPM
Prostate	179.4 nTPM
Placenta	143.9 nTPM
Ovary	135.7 nTPM
Stomach	95.0 nTPM
Adipose tissue	90.8 nTPM
Skin	79.1 nTPM
Breast	77.0 nTPM
Lung	74.8 nTPM
Esophagus	74.0 nTPM
Skeletal muscle	70.3 nTPM

Intestinal goblet cells	293.6 nTPM
Colon	411.0 nTPM
Rectum	284.5 nTPM
Small intestine	185.3 nTPM

Macrophages	136.6 nTPM
Kidney	246.6 nTPM
Pancreas	229.7 nTPM
Prostate	197.2 nTPM
Stomach	175.8 nTPM
Spleen	158.7 nTPM
Bone marrow	145.0 nTPM
Ovary	144.9 nTPM
Testis	135.9 nTPM
Adipose tissue	135.9 nTPM
Lung	89.7 nTPM
Breast	88.6 nTPM
Skeletal muscle	85.9 nTPM
Endometrium	83.7 nTPM
Esophagus	77.1 nTPM
PBMC	54.6 nTPM

Paneth cells	225.8 nTPM
Rectum	292.6 nTPM
Small intestine	210.2 nTPM
Colon	174.5 nTPM

Plasma cells	159.4 nTPM
Spleen	267.0 nTPM
Bone marrow	191.2 nTPM
Stomach	180.8 nTPM
Esophagus	104.7 nTPM
Adipose tissue	53.5 nTPM

Cholangiocytes	161.5 nTPM
Liver	161.5 nTPM

Collecting duct cells	114.0 nTPM
Kidney	114.0 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Cytotrophoblasts	282.0 nTPM
Placenta	282.0 nTPM

Respiratory ciliated cells	132.4 nTPM
Bronchus	212.2 nTPM
Lung	52.5 nTPM

Smooth muscle cells	131.0 nTPM
Pancreas	242.6 nTPM
Heart muscle	236.9 nTPM
Prostate	183.8 nTPM
Ovary	164.5 nTPM
Bronchus	118.7 nTPM
Breast	98.5 nTPM
Esophagus	93.1 nTPM
Skeletal muscle	91.7 nTPM
Skin	77.4 nTPM
Adipose tissue	70.4 nTPM
Endometrium	63.2 nTPM

T-cells	109.5 nTPM
Kidney	158.1 nTPM
Ovary	153.5 nTPM
Colon	144.4 nTPM
Adipose tissue	142.6 nTPM
PBMC	139.7 nTPM
Stomach	138.1 nTPM
Liver	127.7 nTPM
Skin	119.7 nTPM
Prostate	118.3 nTPM
Spleen	106.7 nTPM
Lung	88.1 nTPM
Bone marrow	87.9 nTPM
Breast	77.2 nTPM
Esophagus	72.0 nTPM
Endometrium	68.0 nTPM
Lymph node	61.6 nTPM
Skeletal muscle	58.7 nTPM

Undifferentiated cells	407.4 nTPM
Colon	495.3 nTPM
Rectum	402.2 nTPM
Small intestine	324.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC