Single cell type - CD2BP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CD2BP2
Gene descriptionⁱ Full gene name according to HGNC.	CD2 cytoplasmic tail binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic cells - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CD2BP2 is part of cluster 1 Pancreatic cells - Digestion with confidenceⁱ 0.8
148 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SDHAF2	Succinate dehydrogenase complex assembly factor 2	0.6427	39
GPKOW	G-patch domain and KOW motifs	0.6102	63
CHMP6	Charged multivesicular body protein 6	0.5828	53
FADD	Fas associated via death domain	0.5591	47
TINF2	TERF1 interacting nuclear factor 2	0.5429	63
PPP1CA	Protein phosphatase 1 catalytic subunit alpha	0.5375	53
TMEM199	Transmembrane protein 199	0.5317	3
ZDHHC24	Zinc finger DHHC-type containing 24	0.5247	4
JAGN1	Jagunal homolog 1	0.5215	39
AC114490.2	Novel protein	0.5010	1
SNX11	Sorting nexin 11	0.4990	3
YDJC	YdjC chitooligosaccharide deacetylase homolog	0.4963	1
G6PD	Glucose-6-phosphate dehydrogenase	0.4951	3
MUL1	Mitochondrial E3 ubiquitin protein ligase 1	0.4918	47
LYPLA2	Lysophospholipase 2	0.4915	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	38.1 nTPM
Breast	47.0 nTPM
Adipose tissue	29.1 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	29.0 nTPM
Lung	29.0 nTPM

Astrocytes	7.2 nTPM
Brain	7.2 nTPM

B-cells	39.5 nTPM
Liver	73.8 nTPM
Colon	59.1 nTPM
PBMC	57.1 nTPM
Breast	44.1 nTPM
Stomach	31.8 nTPM
Spleen	30.4 nTPM
Bone marrow	28.6 nTPM
Adipose tissue	27.0 nTPM
Kidney	23.8 nTPM
Lymph node	18.9 nTPM

Dendritic cells	57.0 nTPM
PBMC	67.8 nTPM
Adipose tissue	55.1 nTPM
Breast	48.1 nTPM

Endothelial cells	42.8 nTPM
Pancreas	100.4 nTPM
Placenta	59.7 nTPM
Ovary	52.5 nTPM
Prostate	48.0 nTPM
Eye	42.9 nTPM
Esophagus	40.7 nTPM
Testis	38.5 nTPM
Breast	37.8 nTPM
Skin	35.9 nTPM
Skeletal muscle	34.8 nTPM
Liver	33.9 nTPM
Endometrium	33.2 nTPM
Heart muscle	24.7 nTPM
Lung	15.6 nTPM

Fibroblasts	36.4 nTPM
Ovary	47.9 nTPM
Breast	47.3 nTPM
Stomach	46.0 nTPM
Prostate	44.3 nTPM
Placenta	38.8 nTPM
Adipose tissue	34.9 nTPM
Skeletal muscle	32.4 nTPM
Skin	31.6 nTPM
Esophagus	29.4 nTPM
Heart muscle	25.6 nTPM
Lung	22.4 nTPM

Intestinal goblet cells	32.7 nTPM
Colon	34.3 nTPM
Rectum	32.8 nTPM
Small intestine	31.0 nTPM

Macrophages	34.0 nTPM
Pancreas	66.4 nTPM
Kidney	62.0 nTPM
Ovary	43.1 nTPM
PBMC	40.9 nTPM
Testis	39.5 nTPM
Bone marrow	37.5 nTPM
Lung	36.0 nTPM
Prostate	31.0 nTPM
Breast	30.2 nTPM
Spleen	27.0 nTPM
Endometrium	26.3 nTPM
Adipose tissue	23.1 nTPM
Skeletal muscle	21.9 nTPM
Stomach	14.7 nTPM
Esophagus	11.0 nTPM

Paneth cells	64.9 nTPM
Colon	82.3 nTPM
Small intestine	67.5 nTPM
Rectum	44.9 nTPM

Plasma cells	52.7 nTPM
Bone marrow	75.8 nTPM
Stomach	62.3 nTPM
Spleen	58.2 nTPM
Adipose tissue	42.5 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	46.3 nTPM
Bronchus	57.5 nTPM
Lung	35.0 nTPM

Smooth muscle cells	44.6 nTPM
Pancreas	85.3 nTPM
Ovary	59.8 nTPM
Heart muscle	50.3 nTPM
Prostate	49.7 nTPM
Breast	41.8 nTPM
Bronchus	40.4 nTPM
Skin	37.7 nTPM
Skeletal muscle	33.5 nTPM
Endometrium	31.1 nTPM
Esophagus	31.0 nTPM
Adipose tissue	30.3 nTPM

T-cells	41.9 nTPM
Ovary	77.9 nTPM
Colon	71.7 nTPM
Liver	71.6 nTPM
Kidney	56.2 nTPM
PBMC	52.5 nTPM
Bone marrow	42.9 nTPM
Adipose tissue	42.3 nTPM
Stomach	39.4 nTPM
Lung	34.9 nTPM
Endometrium	34.5 nTPM
Spleen	34.2 nTPM
Skin	34.0 nTPM
Skeletal muscle	30.9 nTPM
Breast	30.9 nTPM
Esophagus	26.2 nTPM
Lymph node	18.5 nTPM
Prostate	14.2 nTPM

Basal keratinocytes	28.8 nTPM
Skin	28.8 nTPM

Basal prostatic cells	49.6 nTPM
Prostate	49.6 nTPM

Basal respiratory cells	58.4 nTPM
Bronchus	58.4 nTPM

Basal squamous epithelial cells	31.9 nTPM
Esophagus	31.9 nTPM

Undifferentiated cells	31.6 nTPM
Colon	32.3 nTPM
Small intestine	32.3 nTPM
Rectum	30.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC