Single cell type - PRELID1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRELID1
Gene descriptionⁱ Full gene name according to HGNC.	PRELI domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic endocrine cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRELID1 is part of cluster 16 Pancreatic endocrine cells - Mixed function with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RALY	RALY heterogeneous nuclear ribonucleoprotein	0.7042	53
CLTB	Clathrin light chain B	0.6741	16
RHOC	Ras homolog family member C	0.6684	16
ARHGDIA	Rho GDP dissociation inhibitor alpha	0.6503	16
SDCBP2	Syndecan binding protein 2	0.6382	16
FAM32A	Family with sequence similarity 32 member A	0.6379	53
EIF6	Eukaryotic translation initiation factor 6	0.6325	16
HMGA1	High mobility group AT-hook 1	0.6069	16
MALL	Mal, T cell differentiation protein like	0.6032	53
PPP4C	Protein phosphatase 4 catalytic subunit	0.5996	53
POLR2J	RNA polymerase II subunit J	0.5813	53
PPARD	Peroxisome proliferator activated receptor delta	0.5752	53
LAMA3	Laminin subunit alpha 3	0.5744	16
CDA	Cytidine deaminase	0.5714	53
CHMP2A	Charged multivesicular body protein 2A	0.5694	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	174.4 nTPM
Breast	238.7 nTPM
Adipose tissue	109.9 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	23.4 nTPM
Lung	23.4 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	198.3 nTPM
Liver	537.6 nTPM
Breast	272.9 nTPM
Colon	222.1 nTPM
Kidney	166.7 nTPM
Spleen	165.8 nTPM
PBMC	164.2 nTPM
Stomach	134.4 nTPM
Bone marrow	127.6 nTPM
Lymph node	97.4 nTPM
Adipose tissue	94.7 nTPM

Basal squamous epithelial cells	152.5 nTPM
Esophagus	152.5 nTPM

Dendritic cells	231.4 nTPM
Breast	312.4 nTPM
PBMC	199.3 nTPM
Adipose tissue	182.7 nTPM

Endothelial cells	171.5 nTPM
Pancreas	393.8 nTPM
Prostate	336.5 nTPM
Ovary	257.9 nTPM
Skin	227.9 nTPM
Placenta	220.0 nTPM
Breast	213.2 nTPM
Testis	134.2 nTPM
Liver	128.4 nTPM
Esophagus	126.2 nTPM
Eye	116.5 nTPM
Endometrium	104.2 nTPM
Skeletal muscle	101.2 nTPM
Lung	40.6 nTPM
Heart muscle	0.7 nTPM

Enteroendocrine cells	157.5 nTPM
Colon	220.3 nTPM
Rectum	94.7 nTPM

Erythroid cells	128.9 nTPM
Bone marrow	177.4 nTPM
Liver	80.4 nTPM

Fibroblasts	134.0 nTPM
Ovary	231.1 nTPM
Prostate	226.8 nTPM
Placenta	224.8 nTPM
Skin	197.1 nTPM
Breast	144.2 nTPM
Adipose tissue	119.3 nTPM
Stomach	92.0 nTPM
Esophagus	89.1 nTPM
Skeletal muscle	88.1 nTPM
Lung	59.2 nTPM
Heart muscle	1.9 nTPM

Intestinal goblet cells	311.3 nTPM
Colon	463.1 nTPM
Small intestine	286.9 nTPM
Rectum	183.8 nTPM

Macrophages	293.8 nTPM
Kidney	708.6 nTPM
Pancreas	528.3 nTPM
Spleen	464.5 nTPM
Stomach	442.5 nTPM
Bone marrow	429.8 nTPM
Skeletal muscle	248.8 nTPM
Breast	233.1 nTPM
Endometrium	225.1 nTPM
Adipose tissue	218.0 nTPM
Prostate	217.7 nTPM
Esophagus	214.0 nTPM
Ovary	170.5 nTPM
Testis	141.7 nTPM
Lung	95.7 nTPM
PBMC	68.2 nTPM

Paneth cells	664.0 nTPM
Colon	1314.2 nTPM
Small intestine	367.9 nTPM
Rectum	310.0 nTPM

Plasma cells	393.9 nTPM
Spleen	650.6 nTPM
Bone marrow	454.8 nTPM
Stomach	409.3 nTPM
Esophagus	332.5 nTPM
Adipose tissue	122.6 nTPM

Cholangiocytes	168.7 nTPM
Liver	168.7 nTPM

Collecting duct cells	104.8 nTPM
Kidney	104.8 nTPM

Cone photoreceptor cells	22.9 nTPM
Eye	22.9 nTPM

Cytotrophoblasts	756.9 nTPM
Placenta	756.9 nTPM

Respiratory ciliated cells	60.5 nTPM
Bronchus	106.3 nTPM
Lung	14.6 nTPM

Smooth muscle cells	177.3 nTPM
Pancreas	586.2 nTPM
Ovary	248.9 nTPM
Prostate	188.2 nTPM
Skin	185.6 nTPM
Bronchus	185.2 nTPM
Breast	168.2 nTPM
Esophagus	105.5 nTPM
Skeletal muscle	95.6 nTPM
Endometrium	93.8 nTPM
Adipose tissue	88.7 nTPM
Heart muscle	4.1 nTPM

T-cells	169.7 nTPM
Ovary	260.2 nTPM
Colon	218.1 nTPM
Skin	216.9 nTPM
Liver	213.9 nTPM
Kidney	210.1 nTPM
PBMC	202.4 nTPM
Stomach	202.0 nTPM
Breast	189.5 nTPM
Bone marrow	186.8 nTPM
Spleen	161.5 nTPM
Prostate	151.5 nTPM
Esophagus	150.6 nTPM
Endometrium	137.0 nTPM
Skeletal muscle	133.8 nTPM
Adipose tissue	108.2 nTPM
Lymph node	105.9 nTPM
Lung	36.5 nTPM

Undifferentiated cells	433.6 nTPM
Colon	624.6 nTPM
Small intestine	404.5 nTPM
Rectum	271.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC