Single cell type - TMEM192 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM192
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 192
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM192 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SUOX	Sulfite oxidase	0.5327	67
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.5325	10
ACO1	Aconitase 1	0.5310	67
MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	0.5235	67
TMEM33	Transmembrane protein 33	0.5193	10
SNX4	Sorting nexin 4	0.4868	67
DHTKD1	Dehydrogenase E1 and transketolase domain containing 1	0.4848	67
PSMB5	Proteasome 20S subunit beta 5	0.4841	10
DPYS	Dihydropyrimidinase	0.4836	67
HSD17B10	Hydroxysteroid 17-beta dehydrogenase 10	0.4792	67
UGT1A9	UDP glucuronosyltransferase family 1 member A9	0.4630	67
HPR	Haptoglobin-related protein	0.4629	10
PSMD7	Proteasome 26S subunit, non-ATPase 7	0.4620	10
SLC27A2	Solute carrier family 27 member 2	0.4614	67
SLC22A7	Solute carrier family 22 member 7	0.4609	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.3 nTPM
Adipose tissue	14.0 nTPM
Breast	10.5 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	36.2 nTPM
Lung	36.2 nTPM

Astrocytes	18.9 nTPM
Brain	18.9 nTPM

B-cells	24.0 nTPM
PBMC	47.1 nTPM
Bone marrow	40.0 nTPM
Stomach	24.5 nTPM
Lymph node	22.1 nTPM
Liver	22.0 nTPM
Kidney	19.0 nTPM
Spleen	18.0 nTPM
Colon	17.6 nTPM
Breast	14.7 nTPM
Adipose tissue	14.6 nTPM

Dendritic cells	15.4 nTPM
PBMC	27.9 nTPM
Adipose tissue	11.5 nTPM
Breast	6.9 nTPM

Endothelial cells	19.0 nTPM
Liver	35.7 nTPM
Skin	27.2 nTPM
Testis	26.9 nTPM
Lung	24.9 nTPM
Heart muscle	22.4 nTPM
Esophagus	21.1 nTPM
Prostate	20.2 nTPM
Endometrium	19.0 nTPM
Skeletal muscle	17.4 nTPM
Breast	15.5 nTPM
Ovary	11.4 nTPM
Placenta	10.8 nTPM
Pancreas	7.7 nTPM
Eye	6.5 nTPM

Fibroblasts	18.9 nTPM
Lung	29.0 nTPM
Skin	25.6 nTPM
Esophagus	24.1 nTPM
Prostate	22.2 nTPM
Heart muscle	19.2 nTPM
Skeletal muscle	17.3 nTPM
Adipose tissue	16.9 nTPM
Placenta	16.6 nTPM
Ovary	15.4 nTPM
Breast	14.3 nTPM
Stomach	7.4 nTPM

Intestinal goblet cells	18.2 nTPM
Rectum	24.9 nTPM
Colon	15.7 nTPM
Small intestine	14.0 nTPM

Macrophages	22.3 nTPM
Ovary	40.5 nTPM
Lung	36.1 nTPM
Pancreas	35.7 nTPM
Testis	31.4 nTPM
Skeletal muscle	26.4 nTPM
Spleen	26.0 nTPM
Kidney	21.1 nTPM
Prostate	20.7 nTPM
Esophagus	20.4 nTPM
Bone marrow	20.0 nTPM
Adipose tissue	18.9 nTPM
Endometrium	17.7 nTPM
Breast	17.1 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	14.3 nTPM
Rectum	24.7 nTPM
Small intestine	15.0 nTPM
Colon	3.3 nTPM

Plasma cells	11.8 nTPM
Bone marrow	13.2 nTPM
Stomach	12.9 nTPM
Esophagus	12.3 nTPM
Spleen	12.0 nTPM
Adipose tissue	8.4 nTPM

Respiratory ciliated cells	10.9 nTPM
Lung	13.1 nTPM
Bronchus	8.6 nTPM

Smooth muscle cells	20.7 nTPM
Bronchus	65.0 nTPM
Heart muscle	27.6 nTPM
Esophagus	23.3 nTPM
Ovary	19.2 nTPM
Skeletal muscle	17.3 nTPM
Skin	16.4 nTPM
Prostate	14.7 nTPM
Adipose tissue	13.3 nTPM
Endometrium	12.0 nTPM
Breast	10.1 nTPM
Pancreas	8.7 nTPM

T-cells	15.9 nTPM
Lung	38.0 nTPM
PBMC	24.4 nTPM
Prostate	23.6 nTPM
Liver	23.3 nTPM
Kidney	21.2 nTPM
Skeletal muscle	19.9 nTPM
Bone marrow	15.2 nTPM
Skin	14.3 nTPM
Stomach	12.8 nTPM
Lymph node	12.4 nTPM
Breast	12.2 nTPM
Spleen	11.4 nTPM
Endometrium	10.5 nTPM
Colon	9.5 nTPM
Adipose tissue	8.5 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	9.7 nTPM
Skin	9.7 nTPM

Basal prostatic cells	18.4 nTPM
Prostate	18.4 nTPM

Basal squamous epithelial cells	10.2 nTPM
Esophagus	10.2 nTPM

Cholangiocytes	42.9 nTPM
Liver	42.9 nTPM

Undifferentiated cells	24.0 nTPM
Rectum	35.0 nTPM
Small intestine	22.2 nTPM
Colon	14.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC