Single cell type - NDUFA3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFA3
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit A3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Proximal tubular cells, Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Proximal tubular cells, Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFA3 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MRPS25	Mitochondrial ribosomal protein S25	0.7911	31
NDUFV3	NADH:ubiquinone oxidoreductase subunit V3	0.7255	31
NDUFB10	NADH:ubiquinone oxidoreductase subunit B10	0.6601	39
NDUFA13	NADH:ubiquinone oxidoreductase subunit A13	0.6599	25
AURKAIP1	Aurora kinase A interacting protein 1	0.6380	31
MTFR1L	Mitochondrial fission regulator 1 like	0.6241	31
PHPT1	Phosphohistidine phosphatase 1	0.6220	39
CLCNKB	Chloride voltage-gated channel Kb	0.6167	31
ZNF688	Zinc finger protein 688	0.6148	31
MRPL41	Mitochondrial ribosomal protein L41	0.6074	39
NDUFA11	NADH:ubiquinone oxidoreductase subunit A11	0.6022	39
ADO	2-aminoethanethiol dioxygenase	0.5963	31
COX6B1	Cytochrome c oxidase subunit 6B1	0.5932	39
GPX4	Glutathione peroxidase 4	0.5807	31
NDUFS8	NADH:ubiquinone oxidoreductase core subunit S8	0.5775	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	146.9 nTPM
Adipose tissue	151.0 nTPM
Breast	142.8 nTPM

Alveolar cells type 1	96.1 nTPM
Lung	96.1 nTPM

Alveolar cells type 2	117.4 nTPM
Lung	117.4 nTPM

Astrocytes	4.6 nTPM
Brain	4.6 nTPM

B-cells	168.1 nTPM
Liver	338.6 nTPM
Kidney	228.5 nTPM
Spleen	186.9 nTPM
PBMC	154.1 nTPM
Bone marrow	152.9 nTPM
Stomach	144.4 nTPM
Breast	144.4 nTPM
Adipose tissue	133.9 nTPM
Colon	111.8 nTPM
Lymph node	85.5 nTPM

Dendritic cells	158.3 nTPM
Adipose tissue	175.5 nTPM
PBMC	151.4 nTPM
Breast	147.9 nTPM

Endothelial cells	118.2 nTPM
Heart muscle	264.5 nTPM
Placenta	198.4 nTPM
Liver	179.8 nTPM
Breast	170.6 nTPM
Testis	127.4 nTPM
Pancreas	115.9 nTPM
Eye	109.2 nTPM
Endometrium	104.8 nTPM
Lung	81.1 nTPM
Skeletal muscle	79.9 nTPM
Skin	67.2 nTPM
Esophagus	64.1 nTPM
Ovary	60.8 nTPM
Prostate	31.4 nTPM

Enteroendocrine cells	300.5 nTPM
Rectum	366.5 nTPM
Colon	234.5 nTPM

Erythroid cells	169.0 nTPM
Liver	208.5 nTPM
Bone marrow	129.5 nTPM

Fibroblasts	122.9 nTPM
Heart muscle	381.2 nTPM
Adipose tissue	154.9 nTPM
Placenta	145.8 nTPM
Breast	143.8 nTPM
Lung	135.2 nTPM
Stomach	89.1 nTPM
Skin	77.3 nTPM
Esophagus	72.8 nTPM
Ovary	71.5 nTPM
Skeletal muscle	52.9 nTPM
Prostate	27.0 nTPM

Intestinal goblet cells	380.2 nTPM
Colon	459.5 nTPM
Rectum	377.5 nTPM
Small intestine	303.6 nTPM

Macrophages	181.6 nTPM
Kidney	482.5 nTPM
Pancreas	331.8 nTPM
Spleen	206.3 nTPM
Ovary	191.4 nTPM
Stomach	187.5 nTPM
Lung	184.7 nTPM
Bone marrow	182.4 nTPM
Testis	177.2 nTPM
Endometrium	176.6 nTPM
Breast	144.8 nTPM
Adipose tissue	127.0 nTPM
PBMC	109.1 nTPM
Esophagus	88.1 nTPM
Skeletal muscle	82.0 nTPM
Prostate	52.7 nTPM

Paneth cells	448.8 nTPM
Colon	619.3 nTPM
Small intestine	367.9 nTPM
Rectum	359.4 nTPM

Plasma cells	232.7 nTPM
Spleen	331.6 nTPM
Stomach	293.4 nTPM
Bone marrow	230.7 nTPM
Esophagus	160.2 nTPM
Adipose tissue	147.8 nTPM

Respiratory ciliated cells	225.1 nTPM
Bronchus	243.2 nTPM
Lung	206.9 nTPM

Basal keratinocytes	39.8 nTPM
Skin	39.8 nTPM

Basal prostatic cells	53.5 nTPM
Prostate	53.5 nTPM

Basal respiratory cells	266.5 nTPM
Bronchus	266.5 nTPM

Basal squamous epithelial cells	58.6 nTPM
Esophagus	58.6 nTPM

Smooth muscle cells	125.8 nTPM
Heart muscle	391.2 nTPM
Pancreas	155.1 nTPM
Adipose tissue	133.4 nTPM
Breast	129.9 nTPM
Esophagus	99.2 nTPM
Endometrium	95.3 nTPM
Ovary	90.3 nTPM
Skin	85.4 nTPM
Skeletal muscle	85.2 nTPM
Bronchus	79.2 nTPM
Prostate	39.4 nTPM

T-cells	168.6 nTPM
Kidney	323.0 nTPM
PBMC	244.5 nTPM
Spleen	238.2 nTPM
Stomach	220.5 nTPM
Bone marrow	217.0 nTPM
Liver	209.0 nTPM
Lung	191.3 nTPM
Adipose tissue	176.4 nTPM
Breast	151.9 nTPM
Lymph node	151.7 nTPM
Endometrium	137.2 nTPM
Colon	124.9 nTPM
Skin	121.6 nTPM
Ovary	113.5 nTPM
Skeletal muscle	98.5 nTPM
Esophagus	85.2 nTPM
Prostate	61.6 nTPM

Undifferentiated cells	404.2 nTPM
Colon	455.2 nTPM
Rectum	420.9 nTPM
Small intestine	336.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC