Single cell type - APBB1IP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	APBB1IP
Gene descriptionⁱ Full gene name according to HGNC.	Amyloid beta precursor protein binding family B member 1 interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Microglial cells, dendritic cells, NK-cells, T-cells, Kupffer cells, Macrophages, B-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, MOLT-4, REH, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Microglial cells, dendritic cells, NK-cells, T-cells, Kupffer cells, Macrophages, B-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

APBB1IP is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
VAV1	Vav guanine nucleotide exchange factor 1	0.7131	57
PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	0.6988	63
CORO1A	Coronin 1A	0.6439	63
CSK	C-terminal Src kinase	0.6299	57
NCKAP1L	NCK associated protein 1 like	0.6297	4
PSTPIP1	Proline-serine-threonine phosphatase interacting protein 1	0.6237	63
TMC8	Transmembrane channel like 8	0.6219	63
DOCK8	Dedicator of cytokinesis 8	0.6202	19
RASAL3	RAS protein activator like 3	0.6199	63
WAS	WASP actin nucleation promoting factor	0.6194	19
TBC1D10C	TBC1 domain family member 10C	0.6127	63
DENND1C	DENN domain containing 1C	0.6097	63
RCBTB2	RCC1 and BTB domain containing protein 2	0.5920	63
PLCB2	Phospholipase C beta 2	0.5910	19
IL27RA	Interleukin 27 receptor subunit alpha	0.5877	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	3.2 nTPM
Breast	4.9 nTPM
Adipose tissue	1.6 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	25.3 nTPM
Lung	25.3 nTPM

Astrocytes	1.6 nTPM
Brain	1.6 nTPM

Basal keratinocytes	1.1 nTPM
Skin	1.1 nTPM

B-cells	88.2 nTPM
Stomach	127.6 nTPM
Lymph node	125.6 nTPM
Bone marrow	121.0 nTPM
PBMC	102.8 nTPM
Spleen	95.9 nTPM
Adipose tissue	95.3 nTPM
Breast	64.1 nTPM
Kidney	57.1 nTPM
Liver	46.7 nTPM
Colon	46.4 nTPM

Dendritic cells	149.1 nTPM
PBMC	211.2 nTPM
Breast	122.8 nTPM
Adipose tissue	113.2 nTPM

Endothelial cells	4.7 nTPM
Eye	41.2 nTPM
Liver	7.3 nTPM
Lung	6.2 nTPM
Heart muscle	3.1 nTPM
Esophagus	2.1 nTPM
Skin	1.6 nTPM
Placenta	1.1 nTPM
Endometrium	1.1 nTPM
Breast	1.1 nTPM
Skeletal muscle	0.8 nTPM
Prostate	0.1 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM

Fibroblasts	15.0 nTPM
Adipose tissue	41.4 nTPM
Esophagus	27.5 nTPM
Skeletal muscle	25.5 nTPM
Breast	23.4 nTPM
Stomach	20.8 nTPM
Heart muscle	9.4 nTPM
Skin	7.7 nTPM
Lung	6.7 nTPM
Placenta	2.4 nTPM
Prostate	0.4 nTPM
Ovary	0.2 nTPM

Intestinal goblet cells	0.2 nTPM
Colon	0.7 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	93.4 nTPM
Breast	169.4 nTPM
Ovary	158.2 nTPM
Bone marrow	138.7 nTPM
Testis	135.4 nTPM
Endometrium	110.7 nTPM
Stomach	108.4 nTPM
Spleen	106.8 nTPM
Lung	97.2 nTPM
Skeletal muscle	86.9 nTPM
Esophagus	81.8 nTPM
Kidney	62.8 nTPM
Adipose tissue	61.8 nTPM
Prostate	52.7 nTPM
Pancreas	30.7 nTPM
PBMC	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	41.7 nTPM
Bone marrow	64.2 nTPM
Adipose tissue	57.4 nTPM
Spleen	38.1 nTPM
Stomach	36.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	3.7 nTPM
Lung	7.3 nTPM
Bronchus	0.1 nTPM

Smooth muscle cells	11.3 nTPM
Bronchus	96.3 nTPM
Pancreas	10.9 nTPM
Breast	7.0 nTPM
Adipose tissue	3.9 nTPM
Skin	2.1 nTPM
Esophagus	1.5 nTPM
Endometrium	1.2 nTPM
Skeletal muscle	1.0 nTPM
Heart muscle	0.4 nTPM
Ovary	0.2 nTPM
Prostate	0.0 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Cytotrophoblasts	2.2 nTPM
Placenta	2.2 nTPM

Endometrial stromal cells	12.8 nTPM
Endometrium	12.8 nTPM

T-cells	125.9 nTPM
Stomach	191.7 nTPM
Bone marrow	167.7 nTPM
Breast	164.8 nTPM
Ovary	160.2 nTPM
Lymph node	151.1 nTPM
PBMC	145.4 nTPM
Lung	141.2 nTPM
Spleen	139.8 nTPM
Skeletal muscle	139.6 nTPM
Adipose tissue	139.6 nTPM
Kidney	115.0 nTPM
Colon	114.0 nTPM
Esophagus	111.4 nTPM
Liver	96.2 nTPM
Endometrium	94.9 nTPM
Skin	44.2 nTPM
Prostate	23.6 nTPM

Undifferentiated cells	0.1 nTPM
Colon	0.3 nTPM
Rectum	0.1 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC