Single cell type - ATF7IP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATF7IP
Gene descriptionⁱ Full gene name according to HGNC.	Activating transcription factor 7 interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	20

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATF7IP is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MSL2	MSL complex subunit 2	0.6780	24
CXCR4	C-X-C motif chemokine receptor 4	0.6408	24
SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1	0.6288	24
CEP120	Centrosomal protein 120	0.6185	59
RGPD2	RANBP2 like and GRIP domain containing 2	0.6165	24
ZNF484	Zinc finger protein 484	0.5791	59
ZNF10	Zinc finger protein 10	0.5724	59
PPP1R16B	Protein phosphatase 1 regulatory subunit 16B	0.5685	59
EPC1	Enhancer of polycomb homolog 1	0.5684	24
SLC25A32	Solute carrier family 25 member 32	0.5659	59
RESF1	Retroelement silencing factor 1	0.5598	24
MARCHF9	Membrane associated ring-CH-type finger 9	0.5311	24
PLEKHA2	Pleckstrin homology domain containing A2	0.5290	24
CENPC	Centromere protein C	0.5249	24
TARS3	Threonyl-tRNA synthetase 3	0.5244	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	46.6 nTPM
Breast	49.2 nTPM
Adipose tissue	44.0 nTPM

Alveolar cells type 1	67.3 nTPM
Lung	67.3 nTPM

Alveolar cells type 2	42.5 nTPM
Lung	42.5 nTPM

Astrocytes	67.9 nTPM
Brain	67.9 nTPM

B-cells	121.2 nTPM
Adipose tissue	281.7 nTPM
Lymph node	191.7 nTPM
Stomach	146.7 nTPM
Bone marrow	137.4 nTPM
Spleen	129.1 nTPM
PBMC	109.9 nTPM
Breast	86.9 nTPM
Colon	47.9 nTPM
Kidney	42.9 nTPM
Liver	38.2 nTPM

Dendritic cells	112.1 nTPM
Adipose tissue	200.5 nTPM
Breast	68.1 nTPM
PBMC	67.8 nTPM

Endothelial cells	40.3 nTPM
Heart muscle	90.6 nTPM
Esophagus	51.6 nTPM
Lung	46.8 nTPM
Endometrium	46.3 nTPM
Breast	43.3 nTPM
Eye	42.9 nTPM
Ovary	41.4 nTPM
Skeletal muscle	41.0 nTPM
Testis	37.7 nTPM
Prostate	34.4 nTPM
Liver	33.0 nTPM
Placenta	23.9 nTPM
Pancreas	19.3 nTPM
Skin	11.6 nTPM

Fibroblasts	32.0 nTPM
Heart muscle	58.7 nTPM
Esophagus	55.9 nTPM
Skeletal muscle	36.2 nTPM
Breast	35.7 nTPM
Adipose tissue	34.3 nTPM
Lung	29.0 nTPM
Stomach	28.2 nTPM
Ovary	28.0 nTPM
Placenta	20.0 nTPM
Prostate	16.3 nTPM
Skin	9.1 nTPM

Intestinal goblet cells	19.6 nTPM
Rectum	28.2 nTPM
Small intestine	23.4 nTPM
Colon	7.2 nTPM

Macrophages	46.3 nTPM
Bone marrow	80.0 nTPM
Esophagus	69.3 nTPM
Adipose tissue	62.0 nTPM
Spleen	58.1 nTPM
Breast	55.5 nTPM
Stomach	49.8 nTPM
Endometrium	45.5 nTPM
Skeletal muscle	44.6 nTPM
Ovary	44.4 nTPM
PBMC	40.9 nTPM
Kidney	36.3 nTPM
Lung	35.2 nTPM
Testis	34.3 nTPM
Prostate	26.3 nTPM
Pancreas	12.8 nTPM

Paneth cells	13.5 nTPM
Rectum	22.6 nTPM
Small intestine	11.3 nTPM
Colon	6.5 nTPM

Plasma cells	85.9 nTPM
Adipose tissue	220.0 nTPM
Stomach	82.7 nTPM
Esophagus	55.5 nTPM
Spleen	36.5 nTPM
Bone marrow	34.6 nTPM

Respiratory ciliated cells	24.3 nTPM
Lung	35.0 nTPM
Bronchus	13.5 nTPM

Smooth muscle cells	33.3 nTPM
Heart muscle	77.7 nTPM
Esophagus	55.8 nTPM
Adipose tissue	53.9 nTPM
Endometrium	40.9 nTPM
Breast	37.4 nTPM
Skeletal muscle	32.0 nTPM
Ovary	23.9 nTPM
Prostate	19.1 nTPM
Pancreas	9.8 nTPM
Skin	8.7 nTPM
Bronchus	6.6 nTPM

T-cells	98.5 nTPM
Adipose tissue	237.2 nTPM
Stomach	185.6 nTPM
Lymph node	138.6 nTPM
Spleen	133.3 nTPM
Skeletal muscle	129.9 nTPM
Bone marrow	110.7 nTPM
Esophagus	98.3 nTPM
Breast	97.7 nTPM
Endometrium	89.0 nTPM
Colon	85.5 nTPM
PBMC	69.1 nTPM
Lung	66.8 nTPM
Ovary	66.8 nTPM
Liver	66.5 nTPM
Kidney	48.0 nTPM
Skin	27.1 nTPM
Prostate	23.6 nTPM

Basal respiratory cells	9.7 nTPM
Bronchus	9.7 nTPM

Basal squamous epithelial cells	75.1 nTPM
Esophagus	75.1 nTPM

Cone photoreceptor cells	68.8 nTPM
Eye	68.8 nTPM

Cytotrophoblasts	17.2 nTPM
Placenta	17.2 nTPM

Undifferentiated cells	18.3 nTPM
Rectum	26.1 nTPM
Small intestine	22.9 nTPM
Colon	5.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC