Single cell type - METTL18 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	METTL18
Gene descriptionⁱ Full gene name according to HGNC.	Methyltransferase like 18
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

METTL18 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LIPT1	Lipoyltransferase 1	0.5741	66
ZNF766	Zinc finger protein 766	0.5582	52
TRAF3IP3	TRAF3 interacting protein 3	0.5375	63
ZNF101	Zinc finger protein 101	0.5324	63
EAPP	E2F associated phosphoprotein	0.5320	39
FGD3	FYVE, RhoGEF and PH domain containing 3	0.5224	63
RINL	Ras and Rab interactor like	0.5221	63
GIMAP7	GTPase, IMAP family member 7	0.5175	63
CDPF1	Cysteine rich DPF motif domain containing 1	0.5112	63
ANXA2R	Annexin A2 receptor	0.5079	63
C12orf43	Chromosome 12 open reading frame 43	0.5056	63
BTN3A2	Butyrophilin subfamily 3 member A2	0.5035	63
ZNF816	Zinc finger protein 816	0.5025	52
SLC25A45	Solute carrier family 25 member 45	0.4998	63
DENND2D	DENN domain containing 2D	0.4958	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.8 nTPM
Breast	8.0 nTPM
Adipose tissue	3.6 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	4.6 nTPM
Lung	4.6 nTPM

Astrocytes	1.0 nTPM
Brain	1.0 nTPM

B-cells	9.5 nTPM
PBMC	21.4 nTPM
Kidney	19.0 nTPM
Bone marrow	13.9 nTPM
Breast	9.4 nTPM
Spleen	6.9 nTPM
Adipose tissue	6.6 nTPM
Liver	5.5 nTPM
Stomach	5.4 nTPM
Lymph node	4.1 nTPM
Colon	3.2 nTPM

Dendritic cells	4.5 nTPM
Breast	6.9 nTPM
Adipose tissue	6.7 nTPM
PBMC	0.0 nTPM

Endothelial cells	8.3 nTPM
Pancreas	19.3 nTPM
Liver	12.8 nTPM
Testis	12.8 nTPM
Esophagus	10.3 nTPM
Placenta	9.7 nTPM
Skin	7.9 nTPM
Skeletal muscle	7.1 nTPM
Heart muscle	6.5 nTPM
Ovary	6.0 nTPM
Endometrium	5.5 nTPM
Breast	5.5 nTPM
Prostate	5.3 nTPM
Eye	4.1 nTPM
Lung	3.1 nTPM

Fibroblasts	5.5 nTPM
Placenta	8.3 nTPM
Skeletal muscle	7.2 nTPM
Heart muscle	6.9 nTPM
Esophagus	6.3 nTPM
Ovary	6.2 nTPM
Breast	6.2 nTPM
Lung	5.6 nTPM
Stomach	4.4 nTPM
Adipose tissue	3.7 nTPM
Skin	2.9 nTPM
Prostate	2.7 nTPM

Intestinal goblet cells	3.6 nTPM
Rectum	7.6 nTPM
Small intestine	2.4 nTPM
Colon	0.7 nTPM

Macrophages	3.7 nTPM
Testis	9.2 nTPM
Kidney	6.8 nTPM
Breast	6.8 nTPM
Ovary	6.5 nTPM
Bone marrow	6.2 nTPM
Lung	3.2 nTPM
Esophagus	3.1 nTPM
Skeletal muscle	3.0 nTPM
Pancreas	2.5 nTPM
Prostate	2.2 nTPM
Spleen	2.1 nTPM
Endometrium	2.0 nTPM
Adipose tissue	1.6 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	5.7 nTPM
Rectum	6.7 nTPM
Colon	6.5 nTPM
Small intestine	3.7 nTPM

Plasma cells	2.5 nTPM
Stomach	4.4 nTPM
Spleen	4.0 nTPM
Adipose tissue	2.7 nTPM
Bone marrow	1.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	10.9 nTPM
Lung	14.6 nTPM
Bronchus	7.3 nTPM

Smooth muscle cells	6.5 nTPM
Heart muscle	19.1 nTPM
Bronchus	13.2 nTPM
Pancreas	9.3 nTPM
Breast	6.8 nTPM
Ovary	6.6 nTPM
Skeletal muscle	3.8 nTPM
Endometrium	3.7 nTPM
Prostate	2.8 nTPM
Skin	2.8 nTPM
Adipose tissue	1.8 nTPM
Esophagus	1.5 nTPM

T-cells	10.1 nTPM
PBMC	24.6 nTPM
Kidney	19.1 nTPM
Liver	16.4 nTPM
Esophagus	13.1 nTPM
Bone marrow	13.0 nTPM
Skin	11.1 nTPM
Ovary	11.1 nTPM
Lung	9.1 nTPM
Breast	8.5 nTPM
Colon	8.1 nTPM
Spleen	6.9 nTPM
Lymph node	6.3 nTPM
Stomach	6.3 nTPM
Adipose tissue	5.3 nTPM
Prostate	4.7 nTPM
Endometrium	4.4 nTPM
Skeletal muscle	3.3 nTPM

Basal prostatic cells	6.1 nTPM
Prostate	6.1 nTPM

Basal respiratory cells	10.8 nTPM
Bronchus	10.8 nTPM

Cytotrophoblasts	13.7 nTPM
Placenta	13.7 nTPM

Distal tubular cells	25.4 nTPM
Kidney	25.4 nTPM

Undifferentiated cells	5.5 nTPM
Small intestine	7.0 nTPM
Colon	4.8 nTPM
Rectum	4.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC