Single cell type - NET1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NET1
Gene descriptionⁱ Full gene name according to HGNC.	Neuroepithelial cell transforming 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (naive CD4 T-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BEWO)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NET1 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PACSIN2	Protein kinase C and casein kinase substrate in neurons 2	0.5912	53
EPS8	Epidermal growth factor receptor pathway substrate 8	0.5231	53
CYP2S1	Cytochrome P450 family 2 subfamily S member 1	0.5185	41
DSC2	Desmocollin 2	0.5170	61
PDGFA	Platelet derived growth factor subunit A	0.5093	48
VDR	Vitamin D receptor	0.4897	53
PADI2	Peptidyl arginine deiminase 2	0.4896	53
KIF16B	Kinesin family member 16B	0.4854	53
HOXA13	Homeobox A13	0.4703	53
MXD1	MAX dimerization protein 1	0.4679	53
PLEKHG6	Pleckstrin homology and RhoGEF domain containing G6	0.4646	53
ST6GALNAC6	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	0.4630	53
SLC26A2	Solute carrier family 26 member 2	0.4574	53
CDH17	Cadherin 17	0.4568	53
FOXH1	Forkhead box H1	0.4561	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	18.4 nTPM
Adipose tissue	21.2 nTPM
Breast	15.7 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	55.8 nTPM
Lung	55.8 nTPM

Astrocytes	2.6 nTPM
Brain	2.6 nTPM

B-cells	12.7 nTPM
Liver	36.7 nTPM
Lymph node	18.0 nTPM
Colon	17.6 nTPM
Stomach	13.6 nTPM
Spleen	12.5 nTPM
Adipose tissue	10.5 nTPM
Breast	9.4 nTPM
PBMC	4.3 nTPM
Bone marrow	4.1 nTPM
Kidney	0.0 nTPM

Basal squamous epithelial cells	103.0 nTPM
Esophagus	103.0 nTPM

Dendritic cells	8.4 nTPM
Adipose tissue	13.1 nTPM
PBMC	8.0 nTPM
Breast	4.0 nTPM

Endothelial cells	42.7 nTPM
Esophagus	111.0 nTPM
Eye	86.6 nTPM
Skin	61.9 nTPM
Breast	52.2 nTPM
Liver	46.7 nTPM
Skeletal muscle	44.5 nTPM
Prostate	38.5 nTPM
Endometrium	36.6 nTPM
Heart muscle	33.0 nTPM
Testis	29.6 nTPM
Placenta	28.4 nTPM
Lung	15.6 nTPM
Ovary	8.5 nTPM
Pancreas	3.9 nTPM

Fibroblasts	33.2 nTPM
Lung	65.9 nTPM
Stomach	56.4 nTPM
Skin	41.1 nTPM
Adipose tissue	37.6 nTPM
Heart muscle	35.7 nTPM
Placenta	34.6 nTPM
Esophagus	25.4 nTPM
Skeletal muscle	21.4 nTPM
Prostate	17.7 nTPM
Breast	16.3 nTPM
Ovary	13.2 nTPM

Intestinal goblet cells	145.3 nTPM
Colon	178.0 nTPM
Rectum	164.4 nTPM
Small intestine	93.4 nTPM

Macrophages	31.2 nTPM
Adipose tissue	178.8 nTPM
Esophagus	62.9 nTPM
Endometrium	48.1 nTPM
Skeletal muscle	42.2 nTPM
Prostate	36.7 nTPM
Breast	22.7 nTPM
Stomach	14.7 nTPM
PBMC	13.6 nTPM
Testis	13.4 nTPM
Lung	12.9 nTPM
Ovary	8.4 nTPM
Bone marrow	5.0 nTPM
Kidney	4.6 nTPM
Pancreas	2.5 nTPM
Spleen	1.0 nTPM

Paneth cells	148.3 nTPM
Colon	247.0 nTPM
Rectum	126.7 nTPM
Small intestine	71.4 nTPM

Plasma cells	39.2 nTPM
Spleen	78.4 nTPM
Stomach	46.7 nTPM
Bone marrow	41.2 nTPM
Adipose tissue	17.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	85.7 nTPM
Bronchus	86.9 nTPM
Lung	84.5 nTPM

Smooth muscle cells	185.0 nTPM
Esophagus	804.8 nTPM
Heart muscle	260.9 nTPM
Breast	252.6 nTPM
Skin	222.0 nTPM
Endometrium	171.0 nTPM
Adipose tissue	130.6 nTPM
Skeletal muscle	90.1 nTPM
Prostate	65.3 nTPM
Bronchus	15.1 nTPM
Ovary	11.7 nTPM
Pancreas	11.1 nTPM

Cholangiocytes	41.5 nTPM
Liver	41.5 nTPM

Cone photoreceptor cells	4.2 nTPM
Eye	4.2 nTPM

Cytotrophoblasts	110.2 nTPM
Placenta	110.2 nTPM

Distal enterocytes	242.2 nTPM
Rectum	254.6 nTPM
Colon	229.9 nTPM

T-cells	9.3 nTPM
Endometrium	20.8 nTPM
Esophagus	19.7 nTPM
Lymph node	19.0 nTPM
Skin	16.1 nTPM
Lung	12.2 nTPM
Skeletal muscle	10.5 nTPM
Prostate	9.5 nTPM
Colon	7.6 nTPM
Adipose tissue	7.4 nTPM
Spleen	7.4 nTPM
PBMC	6.3 nTPM
Kidney	5.5 nTPM
Stomach	5.4 nTPM
Breast	4.8 nTPM
Bone marrow	3.9 nTPM
Liver	2.9 nTPM
Ovary	0.0 nTPM

Undifferentiated cells	145.0 nTPM
Colon	203.1 nTPM
Rectum	144.6 nTPM
Small intestine	87.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC