Single cell type - MRPS22 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRPS22
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial ribosomal protein S22
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MRPS22 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 0.51
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
AIMP2	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2	0.6522	66
COPS4	COP9 signalosome subunit 4	0.5700	66
ARV1	ARV1 homolog, fatty acid homeostasis modulator	0.5661	66
EMC2	ER membrane protein complex subunit 2	0.5626	26
NTPCR	Nucleoside-triphosphatase, cancer-related	0.5588	39
NDUFA8	NADH:ubiquinone oxidoreductase subunit A8	0.5550	39
CCT7	Chaperonin containing TCP1 subunit 7	0.5437	39
MTRF1	Mitochondrial translation release factor 1	0.5303	66
MRPL39	Mitochondrial ribosomal protein L39	0.5266	66
GGNBP2	Gametogenetin binding protein 2	0.5222	66
MRPL47	Mitochondrial ribosomal protein L47	0.5220	66
RMDN1	Regulator of microtubule dynamics 1	0.5137	39
MRPS9	Mitochondrial ribosomal protein S9	0.5074	66
RARS2	Arginyl-tRNA synthetase 2, mitochondrial	0.4918	66
PLRG1	Pleiotropic regulator 1	0.4880	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	30.7 nTPM
Breast	33.5 nTPM
Adipose tissue	27.9 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	13.4 nTPM
Lung	13.4 nTPM

Astrocytes	8.8 nTPM
Brain	8.8 nTPM

B-cells	21.8 nTPM
Liver	44.4 nTPM
Adipose tissue	27.6 nTPM
Colon	23.9 nTPM
Breast	22.8 nTPM
Stomach	22.3 nTPM
PBMC	18.6 nTPM
Spleen	18.3 nTPM
Bone marrow	18.0 nTPM
Lymph node	17.4 nTPM
Kidney	4.8 nTPM

Dendritic cells	24.9 nTPM
Adipose tissue	32.7 nTPM
Breast	22.2 nTPM
PBMC	20.0 nTPM

Endothelial cells	26.6 nTPM
Pancreas	54.0 nTPM
Placenta	39.3 nTPM
Testis	32.3 nTPM
Skeletal muscle	31.4 nTPM
Ovary	27.2 nTPM
Prostate	26.8 nTPM
Esophagus	24.2 nTPM
Breast	22.4 nTPM
Eye	21.8 nTPM
Lung	21.8 nTPM
Heart muscle	21.5 nTPM
Endometrium	20.6 nTPM
Skin	17.3 nTPM
Liver	11.9 nTPM

Fibroblasts	27.7 nTPM
Placenta	38.8 nTPM
Adipose tissue	37.8 nTPM
Ovary	33.2 nTPM
Skeletal muscle	28.7 nTPM
Heart muscle	27.3 nTPM
Stomach	25.3 nTPM
Lung	24.6 nTPM
Breast	23.4 nTPM
Esophagus	23.0 nTPM
Prostate	22.0 nTPM
Skin	20.3 nTPM

Intestinal goblet cells	26.5 nTPM
Rectum	31.4 nTPM
Colon	27.9 nTPM
Small intestine	20.2 nTPM

Macrophages	22.5 nTPM
Pancreas	43.4 nTPM
Adipose tissue	29.6 nTPM
Lung	27.4 nTPM
Ovary	27.3 nTPM
Kidney	23.4 nTPM
Prostate	22.9 nTPM
Breast	22.8 nTPM
Endometrium	22.2 nTPM
Testis	22.1 nTPM
Skeletal muscle	21.3 nTPM
Stomach	20.5 nTPM
Esophagus	15.8 nTPM
PBMC	13.6 nTPM
Spleen	13.5 nTPM
Bone marrow	11.3 nTPM

Paneth cells	27.1 nTPM
Rectum	39.4 nTPM
Colon	23.1 nTPM
Small intestine	18.8 nTPM

Plasma cells	38.4 nTPM
Esophagus	61.7 nTPM
Stomach	39.9 nTPM
Spleen	35.5 nTPM
Bone marrow	29.7 nTPM
Adipose tissue	25.2 nTPM

Respiratory ciliated cells	35.5 nTPM
Lung	40.8 nTPM
Bronchus	30.1 nTPM

Smooth muscle cells	39.1 nTPM
Bronchus	112.5 nTPM
Pancreas	63.8 nTPM
Ovary	37.4 nTPM
Skeletal muscle	31.3 nTPM
Prostate	27.2 nTPM
Adipose tissue	27.2 nTPM
Breast	27.2 nTPM
Heart muscle	27.0 nTPM
Esophagus	26.4 nTPM
Endometrium	26.1 nTPM
Skin	24.0 nTPM

T-cells	24.7 nTPM
Adipose tissue	37.0 nTPM
Ovary	35.6 nTPM
Colon	31.4 nTPM
Stomach	28.8 nTPM
Lung	27.4 nTPM
PBMC	26.7 nTPM
Kidney	25.3 nTPM
Liver	24.8 nTPM
Prostate	23.6 nTPM
Endometrium	23.2 nTPM
Breast	23.2 nTPM
Bone marrow	21.8 nTPM
Spleen	21.3 nTPM
Skin	20.7 nTPM
Skeletal muscle	18.7 nTPM
Lymph node	16.8 nTPM
Esophagus	13.1 nTPM

Basal respiratory cells	63.3 nTPM
Bronchus	63.3 nTPM

Basal squamous epithelial cells	19.4 nTPM
Esophagus	19.4 nTPM

Cholangiocytes	25.8 nTPM
Liver	25.8 nTPM

Collecting duct cells	18.4 nTPM
Kidney	18.4 nTPM

Undifferentiated cells	46.5 nTPM
Small intestine	48.7 nTPM
Colon	47.1 nTPM
Rectum	43.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC