Single cell type - GOLGA8A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GOLGA8A
Gene descriptionⁱ Full gene name according to HGNC.	Golgin A8 family member A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 1, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL, HeLa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 1, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GOLGA8A is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GOLGA8B	Golgin A8 family member B	0.6609	52
MAP3K12	Mitogen-activated protein kinase kinase kinase 12	0.6351	46
HRNR	Hornerin	0.6231	46
PLA2G4B	Phospholipase A2 group IVB	0.6103	11
PABPC1L	Poly(A) binding protein cytoplasmic 1 like	0.6021	52
AC118553.2	Novel protein	0.6003	52
SREK1	Splicing regulatory glutamic acid and lysine rich protein 1	0.5935	52
CCNL2	Cyclin L2	0.5879	52
AC009779.3	Novel protein	0.5758	11
LUC7L	LUC7 like	0.5741	52
ULK1	Unc-51 like autophagy activating kinase 1	0.5727	46
NKTR	Natural killer cell triggering receptor	0.5716	52
AC091167.6	Novel protein	0.5623	52
GON4L	Gon-4 like	0.5605	46
KLHL17	Kelch like family member 17	0.5541	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	37.3 nTPM
Adipose tissue	43.7 nTPM
Breast	31.0 nTPM

Alveolar cells type 2	71.6 nTPM
Lung	71.6 nTPM

Astrocytes	82.9 nTPM
Brain	82.9 nTPM

B-cells	16.1 nTPM
Breast	45.4 nTPM
Adipose tissue	43.1 nTPM
Liver	17.1 nTPM
PBMC	11.5 nTPM
Spleen	9.7 nTPM
Kidney	9.5 nTPM
Bone marrow	6.6 nTPM
Colon	6.4 nTPM
Stomach	6.4 nTPM
Lymph node	5.4 nTPM

Basal keratinocytes	26.1 nTPM
Skin	26.1 nTPM

Dendritic cells	21.1 nTPM
Adipose tissue	30.6 nTPM
Breast	28.8 nTPM
PBMC	4.0 nTPM

Endothelial cells	18.4 nTPM
Lung	34.3 nTPM
Endometrium	30.4 nTPM
Heart muscle	27.3 nTPM
Testis	26.6 nTPM
Skeletal muscle	22.8 nTPM
Breast	21.3 nTPM
Skin	19.7 nTPM
Liver	16.5 nTPM
Prostate	14.6 nTPM
Eye	13.7 nTPM
Ovary	9.0 nTPM
Esophagus	7.8 nTPM
Pancreas	7.7 nTPM
Placenta	5.7 nTPM

Fibroblasts	17.4 nTPM
Breast	36.6 nTPM
Heart muscle	26.9 nTPM
Lung	24.6 nTPM
Ovary	20.9 nTPM
Adipose tissue	20.7 nTPM
Skeletal muscle	20.2 nTPM
Skin	16.1 nTPM
Prostate	7.8 nTPM
Esophagus	7.4 nTPM
Stomach	7.4 nTPM
Placenta	3.4 nTPM

Intestinal goblet cells	11.9 nTPM
Small intestine	18.2 nTPM
Rectum	9.1 nTPM
Colon	8.5 nTPM

Macrophages	8.5 nTPM
Endometrium	30.8 nTPM
Breast	22.8 nTPM
Lung	22.5 nTPM
Esophagus	12.6 nTPM
Adipose tissue	8.6 nTPM
Skeletal muscle	7.2 nTPM
Testis	5.8 nTPM
Pancreas	5.1 nTPM
Prostate	3.4 nTPM
Spleen	3.1 nTPM
Bone marrow	2.5 nTPM
Ovary	1.9 nTPM
Kidney	0.8 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	6.9 nTPM
Small intestine	7.5 nTPM
Rectum	6.7 nTPM
Colon	6.5 nTPM

Plasma cells	19.3 nTPM
Adipose tissue	66.5 nTPM
Spleen	9.1 nTPM
Bone marrow	8.2 nTPM
Stomach	6.7 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	52.0 nTPM
Lung	93.3 nTPM
Bronchus	10.6 nTPM

Smooth muscle cells	22.4 nTPM
Endometrium	57.9 nTPM
Adipose tissue	52.3 nTPM
Breast	33.8 nTPM
Heart muscle	24.9 nTPM
Skin	21.6 nTPM
Skeletal muscle	19.0 nTPM
Ovary	14.2 nTPM
Prostate	11.0 nTPM
Esophagus	6.2 nTPM
Pancreas	5.0 nTPM
Bronchus	0.9 nTPM

T-cells	32.9 nTPM
Lung	156.4 nTPM
Endometrium	103.9 nTPM
Adipose tissue	55.0 nTPM
Skeletal muscle	48.6 nTPM
Breast	48.0 nTPM
Skin	35.0 nTPM
Colon	20.5 nTPM
Ovary	17.8 nTPM
PBMC	14.3 nTPM
Liver	14.1 nTPM
Kidney	10.2 nTPM
Bone marrow	9.2 nTPM
Stomach	6.7 nTPM
Esophagus	6.6 nTPM
Spleen	6.6 nTPM
Lymph node	6.5 nTPM
Prostate	0.0 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Cone photoreceptor cells	100.1 nTPM
Eye	100.1 nTPM

Cytotrophoblasts	2.9 nTPM
Placenta	2.9 nTPM

Early spermatids	37.5 nTPM
Testis	37.5 nTPM

Undifferentiated cells	11.7 nTPM
Small intestine	15.7 nTPM
Rectum	10.5 nTPM
Colon	9.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC