Single cell type - MEX3C - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MEX3C
Gene descriptionⁱ Full gene name according to HGNC.	Mex-3 RNA binding family member C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Early spermatids, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Early spermatids, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MEX3C is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NOXRED1	NADP dependent oxidoreductase domain containing 1	0.7508	34
ARL13A	ADP ribosylation factor like GTPase 13A	0.7391	34
TAS2R1	Taste 2 receptor member 1	0.7358	34
CCDC126	Coiled-coil domain containing 126	0.7309	34
C9orf153	Chromosome 9 open reading frame 153	0.7250	34
MEX3B	Mex-3 RNA binding family member B	0.7200	40
TMEM191B	Transmembrane protein 191B	0.7133	34
FBXO24	F-box protein 24	0.6864	34
FUT11	Fucosyltransferase 11	0.6830	34
TMEM191C	Transmembrane protein 191C	0.6774	34
DDX20	DEAD-box helicase 20	0.6709	34
SPATA9	Spermatogenesis associated 9	0.6694	34
OSGIN2	Oxidative stress induced growth inhibitor family member 2	0.6683	40
PRSS51	Serine protease 51	0.6633	34
ADAM29	ADAM metallopeptidase domain 29	0.6611	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.2 nTPM
Adipose tissue	31.7 nTPM
Breast	18.6 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	5.0 nTPM
Lung	5.0 nTPM

Astrocytes	6.8 nTPM
Brain	6.8 nTPM

B-cells	18.6 nTPM
Adipose tissue	38.6 nTPM
Lymph node	27.7 nTPM
PBMC	25.7 nTPM
Breast	18.7 nTPM
Colon	16.0 nTPM
Spleen	14.9 nTPM
Stomach	13.2 nTPM
Liver	12.7 nTPM
Kidney	9.5 nTPM
Bone marrow	9.0 nTPM

Dendritic cells	56.6 nTPM
Adipose tissue	121.8 nTPM
Breast	40.1 nTPM
PBMC	8.0 nTPM

Endothelial cells	30.0 nTPM
Skin	73.1 nTPM
Esophagus	51.7 nTPM
Endometrium	40.5 nTPM
Prostate	37.7 nTPM
Heart muscle	33.5 nTPM
Skeletal muscle	31.9 nTPM
Testis	27.5 nTPM
Breast	27.5 nTPM
Ovary	24.3 nTPM
Pancreas	19.3 nTPM
Placenta	16.5 nTPM
Lung	15.6 nTPM
Liver	11.9 nTPM
Eye	8.9 nTPM

Fibroblasts	18.2 nTPM
Skin	34.0 nTPM
Heart muscle	19.4 nTPM
Esophagus	19.4 nTPM
Lung	19.0 nTPM
Skeletal muscle	17.4 nTPM
Adipose tissue	17.2 nTPM
Placenta	16.7 nTPM
Prostate	16.3 nTPM
Breast	15.0 nTPM
Ovary	14.1 nTPM
Stomach	11.9 nTPM

Intestinal goblet cells	9.4 nTPM
Colon	12.1 nTPM
Rectum	10.5 nTPM
Small intestine	5.7 nTPM

Macrophages	13.8 nTPM
Adipose tissue	30.1 nTPM
Stomach	29.4 nTPM
Endometrium	20.5 nTPM
Skeletal muscle	20.3 nTPM
Spleen	17.6 nTPM
Esophagus	14.2 nTPM
Breast	13.9 nTPM
PBMC	13.6 nTPM
Testis	12.8 nTPM
Ovary	12.5 nTPM
Prostate	8.1 nTPM
Kidney	6.1 nTPM
Bone marrow	5.0 nTPM
Lung	2.6 nTPM
Pancreas	0.0 nTPM

Paneth cells	3.9 nTPM
Rectum	11.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	20.6 nTPM
Adipose tissue	52.9 nTPM
Stomach	25.4 nTPM
Bone marrow	9.9 nTPM
Spleen	8.8 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	6.4 nTPM
Bronchus	9.9 nTPM
Lung	2.9 nTPM

Smooth muscle cells	17.7 nTPM
Endometrium	30.3 nTPM
Skin	28.3 nTPM
Ovary	26.8 nTPM
Bronchus	20.8 nTPM
Adipose tissue	20.8 nTPM
Skeletal muscle	18.3 nTPM
Esophagus	14.0 nTPM
Breast	12.7 nTPM
Prostate	11.6 nTPM
Pancreas	8.2 nTPM
Heart muscle	3.2 nTPM

T-cells	24.2 nTPM
Adipose tissue	61.8 nTPM
Endometrium	49.3 nTPM
Liver	38.7 nTPM
Skeletal muscle	35.5 nTPM
Breast	24.8 nTPM
Skin	24.0 nTPM
Colon	21.9 nTPM
Lymph node	21.6 nTPM
Ovary	20.1 nTPM
Stomach	20.1 nTPM
Spleen	18.0 nTPM
PBMC	15.5 nTPM
Bone marrow	14.5 nTPM
Lung	13.6 nTPM
Esophagus	13.1 nTPM
Kidney	10.2 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	38.2 nTPM
Skin	38.2 nTPM

Basal prostatic cells	10.3 nTPM
Prostate	10.3 nTPM

Basal respiratory cells	12.4 nTPM
Bronchus	12.4 nTPM

Basal squamous epithelial cells	11.4 nTPM
Esophagus	11.4 nTPM

Undifferentiated cells	11.5 nTPM
Small intestine	12.7 nTPM
Rectum	12.6 nTPM
Colon	9.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC