Cell line - PHETA2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PHETA2
Gene descriptionⁱ Full gene name according to HGNC.	PH domain containing endocytic trafficking adaptor 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mesenchymal cell lines - ECM organization (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC TERT1, fHDF/TERT166, HSkMC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

PHETA2 is part of cluster 34 Mesenchymal cell lines - ECM organization with confidenceⁱ 0.87
626 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IGFBP4	Insulin like growth factor binding protein 4	0.7334	34
ATL3	Atlastin GTPase 3	0.6832	20
DAB2	DAB adaptor protein 2	0.6810	10
EHD2	EH domain containing 2	0.6749	10
RCN3	Reticulocalbin 3	0.6591	34
ANPEP	Alanyl aminopeptidase, membrane	0.6583	34
COL5A1	Collagen type V alpha 1 chain	0.6494	10
SASH1	SAM and SH3 domain containing 1	0.6273	34
GPR150	G protein-coupled receptor 150	0.6261	41
SNTB2	Syntrophin beta 2	0.6217	41
PHLDB1	Pleckstrin homology like domain family B member 1	0.6204	34
PRELP	Proline and arginine rich end leucine rich repeat protein	0.6022	34
ZBTB47	Zinc finger and BTB domain containing 47	0.5992	34
HIC1	HIC ZBTB transcriptional repressor 1	0.5968	10
SPARC	Secreted protein acidic and cysteine rich	0.5883	34