Single cell type - TGIF1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TGIF1
Gene descriptionⁱ Full gene name according to HGNC.	TGFB induced factor homeobox 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	21

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal prostatic cells, Basal squamous epithelial cells, Urothelial cells, Basal respiratory cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal prostatic cells, Basal squamous epithelial cells, Urothelial cells, Basal respiratory cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TGIF1 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BAG3	BAG cochaperone 3	0.7600	22
CLK1	CDC like kinase 1	0.7588	22
HSPH1	Heat shock protein family H (Hsp110) member 1	0.7568	22
KRTAP3-1	Keratin associated protein 3-1	0.7544	22
SEMG1	Semenogelin 1	0.7428	22
HSP90AA1	Heat shock protein 90 alpha family class A member 1	0.7296	22
PATE1	Prostate and testis expressed 1	0.7279	22
CXCL8	C-X-C motif chemokine ligand 8	0.7246	22
HSP90AB1	Heat shock protein 90 alpha family class B member 1	0.7126	22
PHLDA1	Pleckstrin homology like domain family A member 1	0.7091	22
GADD45A	Growth arrest and DNA damage inducible alpha	0.7000	22
HSPA1A	Heat shock protein family A (Hsp70) member 1A	0.6895	22
COL4A6	Collagen type IV alpha 6 chain	0.6889	22
KRTAP4-12	Keratin associated protein 4-12	0.6874	22
DLK2	Delta like non-canonical Notch ligand 2	0.6796	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	41.0 nTPM
Adipose tissue	56.8 nTPM
Breast	25.2 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	40.2 nTPM
Lung	40.2 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	106.5 nTPM
Lymph node	257.4 nTPM
Adipose tissue	217.0 nTPM
Stomach	166.2 nTPM
Spleen	147.1 nTPM
Colon	147.0 nTPM
Breast	50.9 nTPM
Bone marrow	27.0 nTPM
PBMC	21.4 nTPM
Kidney	19.0 nTPM
Liver	11.6 nTPM

Basal squamous epithelial cells	483.2 nTPM
Esophagus	483.2 nTPM

Dendritic cells	60.1 nTPM
Adipose tissue	105.5 nTPM
Breast	74.7 nTPM
PBMC	0.0 nTPM

Endothelial cells	66.6 nTPM
Skin	219.7 nTPM
Prostate	204.9 nTPM
Pancreas	88.8 nTPM
Esophagus	61.4 nTPM
Placenta	58.0 nTPM
Breast	56.1 nTPM
Endometrium	53.1 nTPM
Lung	37.4 nTPM
Liver	34.8 nTPM
Ovary	32.0 nTPM
Skeletal muscle	29.3 nTPM
Testis	25.5 nTPM
Eye	20.3 nTPM
Heart muscle	10.5 nTPM

Fibroblasts	102.8 nTPM
Prostate	382.2 nTPM
Skin	218.7 nTPM
Placenta	104.1 nTPM
Lung	95.0 nTPM
Esophagus	78.7 nTPM
Adipose tissue	62.2 nTPM
Skeletal muscle	55.5 nTPM
Stomach	50.5 nTPM
Breast	39.2 nTPM
Ovary	24.7 nTPM
Heart muscle	19.8 nTPM

Intestinal goblet cells	99.4 nTPM
Colon	156.5 nTPM
Rectum	93.6 nTPM
Small intestine	48.0 nTPM

Macrophages	126.8 nTPM
Adipose tissue	378.0 nTPM
Prostate	234.9 nTPM
Esophagus	217.1 nTPM
Stomach	187.5 nTPM
Spleen	169.0 nTPM
Skeletal muscle	145.6 nTPM
Breast	127.5 nTPM
Ovary	116.6 nTPM
Endometrium	109.3 nTPM
Testis	60.4 nTPM
Kidney	52.2 nTPM
Pancreas	43.4 nTPM
Lung	42.0 nTPM
Bone marrow	18.8 nTPM
PBMC	0.0 nTPM

Paneth cells	53.0 nTPM
Colon	69.2 nTPM
Rectum	67.1 nTPM
Small intestine	22.5 nTPM

Plasma cells	15.1 nTPM
Adipose tissue	60.0 nTPM
Esophagus	6.1 nTPM
Stomach	5.5 nTPM
Spleen	2.3 nTPM
Bone marrow	1.7 nTPM

Respiratory ciliated cells	93.3 nTPM
Bronchus	122.4 nTPM
Lung	64.1 nTPM

Smooth muscle cells	86.6 nTPM
Skin	283.7 nTPM
Prostate	209.5 nTPM
Ovary	118.3 nTPM
Bronchus	109.7 nTPM
Pancreas	51.3 nTPM
Esophagus	48.0 nTPM
Endometrium	38.6 nTPM
Skeletal muscle	31.3 nTPM
Breast	25.5 nTPM
Adipose tissue	21.3 nTPM
Heart muscle	14.9 nTPM

Cholangiocytes	100.1 nTPM
Liver	100.1 nTPM

Collecting duct cells	123.2 nTPM
Kidney	123.2 nTPM

Cytotrophoblasts	161.6 nTPM
Placenta	161.6 nTPM

Distal enterocytes	30.0 nTPM
Colon	39.3 nTPM
Rectum	20.6 nTPM

T-cells	103.7 nTPM
Adipose tissue	310.1 nTPM
Skin	264.3 nTPM
Lymph node	189.8 nTPM
Prostate	170.4 nTPM
Esophagus	117.9 nTPM
Breast	107.1 nTPM
Colon	101.7 nTPM
Stomach	101.5 nTPM
Spleen	82.9 nTPM
Skeletal muscle	66.7 nTPM
Endometrium	53.5 nTPM
Kidney	42.4 nTPM
Ovary	42.2 nTPM
Liver	38.5 nTPM
Bone marrow	30.4 nTPM
PBMC	29.1 nTPM
Lung	15.2 nTPM

Undifferentiated cells	91.8 nTPM
Colon	109.2 nTPM
Small intestine	85.0 nTPM
Rectum	81.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC