Single cell type - NR2C2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NR2C2
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear receptor subfamily 2 group C member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Nuclear receptors Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NR2C2 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MTERF4	Mitochondrial transcription termination factor 4	0.5408	63
ZNF678	Zinc finger protein 678	0.4277	68
URI1	URI1 prefoldin like chaperone	0.4095	23
NAA60	N-alpha-acetyltransferase 60, NatF catalytic subunit	0.4039	45
LSM8	LSM8 homolog, U6 small nuclear RNA associated	0.3940	32
HSD17B3	Hydroxysteroid 17-beta dehydrogenase 3	0.3907	42
PRIM2	DNA primase subunit 2	0.3853	42
COLGALT2	Collagen beta(1-O)galactosyltransferase 2	0.3845	42
ZPR1	ZPR1 zinc finger	0.3831	31
ZNF227	Zinc finger protein 227	0.3822	31
NDE1	NudE neurodevelopment protein 1	0.3805	63
AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	0.3792	42
ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	0.3759	42
CPSF7	Cleavage and polyadenylation specific factor 7	0.3750	23
GALNT10	Polypeptide N-acetylgalactosaminyltransferase 10	0.3744	68

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.0 nTPM
Adipose tissue	15.8 nTPM
Breast	12.1 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	12.2 nTPM
Lung	12.2 nTPM

Astrocytes	35.9 nTPM
Brain	35.9 nTPM

B-cells	15.7 nTPM
Lymph node	22.5 nTPM
Bone marrow	22.1 nTPM
Colon	20.8 nTPM
Spleen	19.4 nTPM
Stomach	15.9 nTPM
PBMC	14.3 nTPM
Adipose tissue	14.1 nTPM
Breast	13.4 nTPM
Liver	9.7 nTPM
Kidney	4.8 nTPM

Dendritic cells	15.2 nTPM
Adipose tissue	24.5 nTPM
Breast	13.1 nTPM
PBMC	8.0 nTPM

Endothelial cells	13.4 nTPM
Prostate	33.9 nTPM
Esophagus	19.1 nTPM
Skeletal muscle	18.8 nTPM
Endometrium	18.6 nTPM
Eye	14.6 nTPM
Testis	14.5 nTPM
Breast	14.3 nTPM
Ovary	13.9 nTPM
Placenta	12.5 nTPM
Liver	11.0 nTPM
Heart muscle	6.7 nTPM
Pancreas	3.9 nTPM
Lung	3.1 nTPM
Skin	2.3 nTPM

Fibroblasts	11.5 nTPM
Skeletal muscle	20.1 nTPM
Prostate	16.5 nTPM
Esophagus	16.0 nTPM
Ovary	13.0 nTPM
Breast	12.8 nTPM
Adipose tissue	12.7 nTPM
Placenta	10.4 nTPM
Lung	10.1 nTPM
Heart muscle	6.3 nTPM
Stomach	6.0 nTPM
Skin	2.8 nTPM

Intestinal goblet cells	10.2 nTPM
Small intestine	13.1 nTPM
Rectum	11.5 nTPM
Colon	5.8 nTPM

Macrophages	14.2 nTPM
PBMC	27.3 nTPM
Prostate	26.3 nTPM
Adipose tissue	21.0 nTPM
Skeletal muscle	19.1 nTPM
Testis	16.9 nTPM
Spleen	16.5 nTPM
Stomach	14.7 nTPM
Kidney	12.9 nTPM
Ovary	11.7 nTPM
Breast	11.7 nTPM
Bone marrow	10.0 nTPM
Lung	7.6 nTPM
Endometrium	7.2 nTPM
Pancreas	5.1 nTPM
Esophagus	4.8 nTPM

Paneth cells	12.4 nTPM
Colon	16.5 nTPM
Rectum	13.1 nTPM
Small intestine	7.5 nTPM

Plasma cells	14.2 nTPM
Adipose tissue	21.3 nTPM
Bone marrow	14.8 nTPM
Spleen	12.7 nTPM
Esophagus	12.3 nTPM
Stomach	9.7 nTPM

Respiratory ciliated cells	13.7 nTPM
Lung	26.2 nTPM
Bronchus	1.3 nTPM

Smooth muscle cells	10.3 nTPM
Skeletal muscle	19.6 nTPM
Adipose tissue	16.3 nTPM
Esophagus	15.5 nTPM
Ovary	13.1 nTPM
Prostate	12.9 nTPM
Endometrium	10.9 nTPM
Breast	8.6 nTPM
Pancreas	6.0 nTPM
Heart muscle	5.3 nTPM
Bronchus	2.8 nTPM
Skin	2.1 nTPM

T-cells	15.3 nTPM
Skeletal muscle	29.1 nTPM
Lymph node	24.3 nTPM
Stomach	21.0 nTPM
PBMC	20.6 nTPM
Adipose tissue	20.6 nTPM
Spleen	18.7 nTPM
Bone marrow	18.4 nTPM
Liver	17.8 nTPM
Breast	15.8 nTPM
Lung	15.2 nTPM
Colon	14.7 nTPM
Endometrium	14.0 nTPM
Esophagus	13.1 nTPM
Ovary	6.7 nTPM
Skin	6.0 nTPM
Kidney	3.4 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	3.7 nTPM
Skin	3.7 nTPM

Basal prostatic cells	11.1 nTPM
Prostate	11.1 nTPM

Basal respiratory cells	1.0 nTPM
Bronchus	1.0 nTPM

Basal squamous epithelial cells	17.1 nTPM
Esophagus	17.1 nTPM

Undifferentiated cells	10.4 nTPM
Small intestine	12.5 nTPM
Rectum	11.6 nTPM
Colon	7.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC