Single cell type - SERTAD2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SERTAD2
Gene descriptionⁱ Full gene name according to HGNC.	SERTA domain containing 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal keratinocytes, Basal squamous epithelial cells, Suprabasal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal keratinocytes, Basal squamous epithelial cells, Suprabasal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SERTAD2 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ADAT3	Adenosine deaminase tRNA specific 3	0.6442	61
KLHL21	Kelch like family member 21	0.6264	61
SLC38A2	Solute carrier family 38 member 2	0.6016	7
YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	0.5967	28
PPTC7	Protein phosphatase targeting COQ7	0.5945	41
PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1	0.5917	41
ARL5B	ADP ribosylation factor like GTPase 5B	0.5851	44
TOB2	Transducer of ERBB2, 2	0.5693	7
USP38	Ubiquitin specific peptidase 38	0.5668	44
MAP2K3	Mitogen-activated protein kinase kinase 3	0.5660	44
NRARP	NOTCH regulated ankyrin repeat protein	0.5575	28
ZBTB2	Zinc finger and BTB domain containing 2	0.5485	44
TRIM26	Tripartite motif containing 26	0.5406	44
ARL8B	ADP ribosylation factor like GTPase 8B	0.5299	41
ZNF217	Zinc finger protein 217	0.5280	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.6 nTPM
Adipose tissue	30.1 nTPM
Breast	21.0 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	23.6 nTPM
Lung	23.6 nTPM

Astrocytes	22.9 nTPM
Brain	22.9 nTPM

B-cells	40.8 nTPM
Lymph node	79.1 nTPM
Adipose tissue	73.1 nTPM
Stomach	55.0 nTPM
Bone marrow	45.8 nTPM
Kidney	42.9 nTPM
Spleen	33.9 nTPM
PBMC	27.1 nTPM
Liver	23.0 nTPM
Breast	18.7 nTPM
Colon	9.6 nTPM

Basal squamous epithelial cells	153.1 nTPM
Esophagus	153.1 nTPM

Dendritic cells	33.0 nTPM
Adipose tissue	43.1 nTPM
PBMC	35.8 nTPM
Breast	20.0 nTPM

Endothelial cells	35.4 nTPM
Skin	94.8 nTPM
Esophagus	66.5 nTPM
Lung	40.6 nTPM
Prostate	38.7 nTPM
Endometrium	38.4 nTPM
Skeletal muscle	31.9 nTPM
Placenta	31.8 nTPM
Breast	28.6 nTPM
Heart muscle	25.3 nTPM
Eye	24.2 nTPM
Ovary	24.2 nTPM
Liver	22.0 nTPM
Pancreas	15.5 nTPM
Testis	13.6 nTPM

Fibroblasts	35.1 nTPM
Skin	131.9 nTPM
Prostate	49.8 nTPM
Esophagus	40.9 nTPM
Skeletal muscle	31.1 nTPM
Heart muscle	29.2 nTPM
Lung	23.4 nTPM
Adipose tissue	20.1 nTPM
Breast	19.9 nTPM
Stomach	17.8 nTPM
Placenta	16.6 nTPM
Ovary	5.2 nTPM

Intestinal goblet cells	17.1 nTPM
Rectum	20.6 nTPM
Colon	16.5 nTPM
Small intestine	14.1 nTPM

Macrophages	43.6 nTPM
Adipose tissue	100.6 nTPM
Esophagus	88.1 nTPM
Skeletal muscle	65.3 nTPM
Spleen	57.0 nTPM
Prostate	51.6 nTPM
Endometrium	50.9 nTPM
Ovary	43.7 nTPM
Lung	41.3 nTPM
Bone marrow	35.0 nTPM
Testis	31.4 nTPM
Kidney	30.3 nTPM
Breast	25.4 nTPM
Stomach	20.5 nTPM
Pancreas	12.8 nTPM
PBMC	0.0 nTPM

Paneth cells	45.4 nTPM
Colon	98.9 nTPM
Small intestine	18.8 nTPM
Rectum	18.6 nTPM

Plasma cells	28.1 nTPM
Esophagus	61.7 nTPM
Adipose tissue	43.2 nTPM
Stomach	15.2 nTPM
Spleen	12.3 nTPM
Bone marrow	8.2 nTPM

Respiratory ciliated cells	24.9 nTPM
Bronchus	33.8 nTPM
Lung	16.0 nTPM

Smooth muscle cells	31.0 nTPM
Bronchus	70.4 nTPM
Skin	61.1 nTPM
Prostate	38.1 nTPM
Esophagus	37.2 nTPM
Endometrium	24.2 nTPM
Adipose tissue	24.0 nTPM
Breast	23.3 nTPM
Ovary	19.1 nTPM
Heart muscle	17.5 nTPM
Skeletal muscle	15.7 nTPM
Pancreas	10.7 nTPM

Cholangiocytes	32.9 nTPM
Liver	32.9 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Cytotrophoblasts	38.6 nTPM
Placenta	38.6 nTPM

Distal tubular cells	1.9 nTPM
Kidney	1.9 nTPM

T-cells	25.5 nTPM
Lymph node	46.6 nTPM
Endometrium	41.3 nTPM
Skin	38.7 nTPM
Stomach	34.5 nTPM
Colon	33.2 nTPM
Adipose tissue	32.0 nTPM
Spleen	25.7 nTPM
Breast	23.7 nTPM
Lung	22.8 nTPM
Skeletal muscle	21.9 nTPM
Bone marrow	21.3 nTPM
Esophagus	19.7 nTPM
Prostate	19.0 nTPM
Liver	14.7 nTPM
PBMC	14.6 nTPM
Ovary	13.4 nTPM
Kidney	9.6 nTPM

Undifferentiated cells	13.3 nTPM
Rectum	15.0 nTPM
Colon	14.0 nTPM
Small intestine	10.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC