Single cell type - TSHZ1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TSHZ1
Gene descriptionⁱ Full gene name according to HGNC.	Teashirt zinc finger homeobox 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Peritubular cells, Oligodendrocyte precursor cells, Theca cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Peritubular cells, Oligodendrocyte precursor cells, Theca cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TSHZ1 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZADH2	Zinc binding alcohol dehydrogenase domain containing 2	0.6194	33
CCM2L	CCM2 like scaffold protein	0.5209	52
PHACTR2	Phosphatase and actin regulator 2	0.5164	33
AHDC1	AT-hook DNA binding motif containing 1	0.4953	35
ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif 7	0.4920	52
WFDC1	WAP four-disulfide core domain 1	0.4842	52
CDH11	Cadherin 11	0.4750	33
ENG	Endoglin	0.4737	14
MATN2	Matrilin 2	0.4731	52
LAMC3	Laminin subunit gamma 3	0.4711	52
LRCH2	Leucine rich repeats and calponin homology domain containing 2	0.4704	8
FOXN3	Forkhead box N3	0.4653	44
PLAGL1	PLAG1 like zinc finger 1	0.4619	33
TEK	TEK receptor tyrosine kinase	0.4617	14
PROK1	Prokineticin 1	0.4605	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	60.2 nTPM
Adipose tissue	89.1 nTPM
Breast	31.2 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	14.0 nTPM
Lung	14.0 nTPM

Astrocytes	34.3 nTPM
Brain	34.3 nTPM

B-cells	7.1 nTPM
Adipose tissue	14.6 nTPM
PBMC	8.5 nTPM
Colon	8.0 nTPM
Spleen	7.6 nTPM
Lymph node	6.9 nTPM
Liver	6.3 nTPM
Bone marrow	5.7 nTPM
Stomach	5.4 nTPM
Kidney	4.8 nTPM
Breast	2.6 nTPM

Dendritic cells	25.6 nTPM
Adipose tissue	35.7 nTPM
PBMC	23.9 nTPM
Breast	17.1 nTPM

Endothelial cells	34.4 nTPM
Heart muscle	81.7 nTPM
Skin	75.7 nTPM
Skeletal muscle	39.7 nTPM
Ovary	37.9 nTPM
Prostate	37.3 nTPM
Liver	32.1 nTPM
Breast	31.1 nTPM
Placenta	29.0 nTPM
Testis	22.0 nTPM
Esophagus	20.6 nTPM
Endometrium	19.8 nTPM
Eye	19.4 nTPM
Pancreas	19.3 nTPM
Lung	15.6 nTPM

Fibroblasts	28.8 nTPM
Placenta	77.5 nTPM
Ovary	52.2 nTPM
Skin	34.8 nTPM
Stomach	31.2 nTPM
Skeletal muscle	25.3 nTPM
Adipose tissue	22.2 nTPM
Breast	21.1 nTPM
Esophagus	19.2 nTPM
Heart muscle	15.7 nTPM
Prostate	13.3 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	15.0 nTPM
Rectum	22.9 nTPM
Small intestine	15.7 nTPM
Colon	6.5 nTPM

Macrophages	14.3 nTPM
Adipose tissue	40.2 nTPM
Prostate	26.3 nTPM
Ovary	22.9 nTPM
Skeletal muscle	21.4 nTPM
PBMC	13.6 nTPM
Endometrium	12.3 nTPM
Lung	11.3 nTPM
Bone marrow	11.3 nTPM
Testis	11.1 nTPM
Spleen	10.4 nTPM
Kidney	9.9 nTPM
Esophagus	9.4 nTPM
Breast	8.7 nTPM
Stomach	2.9 nTPM
Pancreas	2.5 nTPM

Paneth cells	14.7 nTPM
Rectum	29.7 nTPM
Small intestine	11.3 nTPM
Colon	3.3 nTPM

Plasma cells	10.6 nTPM
Adipose tissue	31.6 nTPM
Esophagus	12.3 nTPM
Spleen	4.8 nTPM
Stomach	2.8 nTPM
Bone marrow	1.7 nTPM

Respiratory ciliated cells	9.1 nTPM
Lung	13.1 nTPM
Bronchus	5.1 nTPM

Smooth muscle cells	12.2 nTPM
Skin	19.2 nTPM
Endometrium	17.6 nTPM
Adipose tissue	17.6 nTPM
Ovary	16.0 nTPM
Skeletal muscle	13.2 nTPM
Heart muscle	13.1 nTPM
Prostate	11.0 nTPM
Breast	10.7 nTPM
Esophagus	9.3 nTPM
Pancreas	3.6 nTPM
Bronchus	2.8 nTPM

T-cells	18.2 nTPM
Adipose tissue	44.6 nTPM
PBMC	26.3 nTPM
Skeletal muscle	25.4 nTPM
Spleen	21.0 nTPM
Skin	19.8 nTPM
Colon	18.5 nTPM
Lymph node	18.2 nTPM
Liver	18.0 nTPM
Lung	16.7 nTPM
Endometrium	16.1 nTPM
Breast	15.9 nTPM
Bone marrow	15.5 nTPM
Prostate	14.2 nTPM
Stomach	12.4 nTPM
Kidney	11.6 nTPM
Ovary	8.9 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	17.0 nTPM
Skin	17.0 nTPM

Basal prostatic cells	5.6 nTPM
Prostate	5.6 nTPM

Basal squamous epithelial cells	27.9 nTPM
Esophagus	27.9 nTPM

Cholangiocytes	25.8 nTPM
Liver	25.8 nTPM

Undifferentiated cells	17.9 nTPM
Rectum	27.2 nTPM
Small intestine	16.6 nTPM
Colon	9.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC