Single cell type - AHDC1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AHDC1
Gene descriptionⁱ Full gene name according to HGNC.	AT-hook DNA binding motif containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Glandular cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (REH)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AHDC1 is part of cluster 35 Glandular cells - Unknown function with confidenceⁱ 1
101 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IL34	Interleukin 34	0.6767	48
TNKS1BP1	Tankyrase 1 binding protein 1	0.5548	61
ZNF304	Zinc finger protein 304	0.5511	35
CALML5	Calmodulin like 5	0.5396	28
PYDC1	Pyrin domain containing 1	0.5283	35
PKD1	Polycystin 1, transient receptor potential channel interacting	0.5162	62
SYNGAP1	Synaptic Ras GTPase activating protein 1	0.5093	62
CBR3	Carbonyl reductase 3	0.4971	61
TSHZ1	Teashirt zinc finger homeobox 1	0.4953	52
IKZF4	IKAROS family zinc finger 4	0.4885	35
KLF8	Kruppel like factor 8	0.4775	14
ZNF436	Zinc finger protein 436	0.4687	61
ZNF12	Zinc finger protein 12	0.4653	52
SKI	SKI proto-oncogene	0.4646	50
SFRP1	Secreted frizzled related protein 1	0.4634	35

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.3 nTPM
Adipose tissue	23.2 nTPM
Breast	17.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	5.2 nTPM
Lung	5.2 nTPM

Astrocytes	39.2 nTPM
Brain	39.2 nTPM

B-cells	5.8 nTPM
Adipose tissue	10.5 nTPM
Kidney	9.5 nTPM
Breast	8.1 nTPM
Colon	8.0 nTPM
Spleen	5.5 nTPM
Liver	4.6 nTPM
Lymph node	4.4 nTPM
Stomach	3.7 nTPM
Bone marrow	2.5 nTPM
PBMC	1.4 nTPM

Dendritic cells	23.0 nTPM
Breast	26.6 nTPM
PBMC	23.9 nTPM
Adipose tissue	18.3 nTPM

Endothelial cells	19.7 nTPM
Skin	32.1 nTPM
Endometrium	29.8 nTPM
Testis	27.9 nTPM
Skeletal muscle	27.5 nTPM
Ovary	26.0 nTPM
Breast	24.3 nTPM
Pancreas	23.1 nTPM
Placenta	18.8 nTPM
Prostate	13.7 nTPM
Liver	12.8 nTPM
Lung	12.5 nTPM
Esophagus	12.4 nTPM
Heart muscle	8.9 nTPM
Eye	6.5 nTPM

Fibroblasts	24.5 nTPM
Skin	45.6 nTPM
Breast	41.3 nTPM
Skeletal muscle	31.5 nTPM
Adipose tissue	24.2 nTPM
Heart muscle	21.2 nTPM
Placenta	19.9 nTPM
Stomach	19.3 nTPM
Esophagus	18.1 nTPM
Ovary	17.9 nTPM
Prostate	16.0 nTPM
Lung	14.5 nTPM

Intestinal goblet cells	5.5 nTPM
Rectum	8.5 nTPM
Small intestine	4.3 nTPM
Colon	3.6 nTPM

Macrophages	5.8 nTPM
Adipose tissue	14.1 nTPM
Breast	13.4 nTPM
Stomach	11.7 nTPM
Ovary	9.3 nTPM
Endometrium	7.9 nTPM
Skeletal muscle	5.7 nTPM
Pancreas	5.1 nTPM
Kidney	4.6 nTPM
Prostate	4.6 nTPM
Testis	4.0 nTPM
Esophagus	3.1 nTPM
Spleen	2.1 nTPM
Bone marrow	1.2 nTPM
Lung	0.0 nTPM
PBMC	0.0 nTPM

Paneth cells	4.5 nTPM
Rectum	7.0 nTPM
Colon	6.5 nTPM
Small intestine	0.0 nTPM

Plasma cells	5.6 nTPM
Adipose tissue	18.8 nTPM
Esophagus	6.1 nTPM
Stomach	2.6 nTPM
Spleen	0.7 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	17.7 nTPM
Bronchus	29.7 nTPM
Lung	5.8 nTPM

Smooth muscle cells	20.9 nTPM
Skin	40.5 nTPM
Endometrium	32.7 nTPM
Skeletal muscle	32.4 nTPM
Adipose tissue	26.5 nTPM
Breast	23.9 nTPM
Esophagus	18.6 nTPM
Prostate	17.5 nTPM
Ovary	13.2 nTPM
Bronchus	11.3 nTPM
Heart muscle	7.3 nTPM
Pancreas	6.2 nTPM

T-cells	10.5 nTPM
Skin	26.2 nTPM
Prostate	19.0 nTPM
Adipose tissue	17.8 nTPM
Breast	17.3 nTPM
Endometrium	15.6 nTPM
Esophagus	13.1 nTPM
Skeletal muscle	10.5 nTPM
Ovary	8.9 nTPM
PBMC	7.3 nTPM
Colon	6.2 nTPM
Spleen	6.0 nTPM
Lymph node	5.7 nTPM
Liver	5.6 nTPM
Bone marrow	5.5 nTPM
Stomach	5.1 nTPM
Kidney	4.7 nTPM
Lung	4.5 nTPM

Basal keratinocytes	49.5 nTPM
Skin	49.5 nTPM

Basal prostatic cells	9.1 nTPM
Prostate	9.1 nTPM

Basal respiratory cells	25.3 nTPM
Bronchus	25.3 nTPM

Basal squamous epithelial cells	41.5 nTPM
Esophagus	41.5 nTPM

Undifferentiated cells	6.6 nTPM
Rectum	10.1 nTPM
Colon	7.3 nTPM
Small intestine	2.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC