Cell line - SEPTIN1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SEPTIN1
Gene descriptionⁱ Full gene name according to HGNC.	Septin 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	JURKAT & MOLT-4 - Adaptive immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, JURKAT, MOLT-4, REH, U-266/70, U-266/84, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SEPTIN1 is part of cluster 22 JURKAT & MOLT-4 - Adaptive immune response with confidenceⁱ 1
459 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LTA	Lymphotoxin alpha	0.8702	22
CCNI2	Cyclin I family member 2	0.8589	22
GPR174	G protein-coupled receptor 174	0.8447	22
TRBV5-4	T cell receptor beta variable 5-4	0.8437	22
TRAJ7	T cell receptor alpha joining 7	0.8437	22
ZNF575	Zinc finger protein 575	0.8360	22
TRAJ9	T cell receptor alpha joining 9	0.8360	22
TRAJ24	T cell receptor alpha joining 24	0.8322	22
TRAJ10	T cell receptor alpha joining 10	0.8306	22
PVRIG	PVR related immunoglobulin domain containing	0.8277	22
JAKMIP1	Janus kinase and microtubule interacting protein 1	0.8273	22
BCL11B	BAF chromatin remodeling complex subunit BCL11B	0.8269	22
ZAP70	Zeta chain of T cell receptor associated protein kinase 70	0.8209	22
TSPAN7	Tetraspanin 7	0.8204	22
CHI3L2	Chitinase 3 like 2	0.8160	22