Single cell type - MRPL14 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRPL14
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial ribosomal protein L14
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MRPL14 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UBE2K	Ubiquitin conjugating enzyme E2 K	0.5353	10
GPRC5A	G protein-coupled receptor class C group 5 member A	0.5109	22
PSMD11	Proteasome 26S subunit, non-ATPase 11	0.4983	10
TXNRD1	Thioredoxin reductase 1	0.4939	22
COA7	Cytochrome c oxidase assembly factor 7 (putative)	0.4872	10
EMC6	ER membrane protein complex subunit 6	0.4837	10
GMPS	Guanine monophosphate synthase	0.4750	10
UBE2D3	Ubiquitin conjugating enzyme E2 D3	0.4727	10
RHEB	Ras homolog, mTORC1 binding	0.4723	10
SPINK6	Serine peptidase inhibitor Kazal type 6	0.4691	22
EIF2S2	Eukaryotic translation initiation factor 2 subunit beta	0.4685	10
PDCD5	Programmed cell death 5	0.4679	10
RAB10	RAB10, member RAS oncogene family	0.4674	10
LMO7	LIM domain 7	0.4664	22
EIF6	Eukaryotic translation initiation factor 6	0.4645	16

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	48.2 nTPM
Breast	60.5 nTPM
Adipose tissue	35.9 nTPM

Alveolar cells type 1	375.0 nTPM
Lung	375.0 nTPM

Alveolar cells type 2	250.0 nTPM
Lung	250.0 nTPM

Astrocytes	3.6 nTPM
Brain	3.6 nTPM

B-cells	64.5 nTPM
Liver	154.0 nTPM
Kidney	95.3 nTPM
Colon	91.1 nTPM
PBMC	68.5 nTPM
Spleen	63.0 nTPM
Breast	50.9 nTPM
Adipose tissue	46.1 nTPM
Stomach	34.9 nTPM
Bone marrow	25.3 nTPM
Lymph node	16.2 nTPM

Dendritic cells	51.1 nTPM
PBMC	59.8 nTPM
Breast	50.6 nTPM
Adipose tissue	43.0 nTPM

Endothelial cells	82.0 nTPM
Prostate	198.9 nTPM
Pancreas	119.6 nTPM
Skin	111.5 nTPM
Placenta	89.8 nTPM
Breast	88.7 nTPM
Testis	83.6 nTPM
Ovary	77.2 nTPM
Lung	71.7 nTPM
Eye	69.6 nTPM
Liver	64.2 nTPM
Heart muscle	60.4 nTPM
Skeletal muscle	41.0 nTPM
Endometrium	39.5 nTPM
Esophagus	33.0 nTPM

Fibroblasts	76.4 nTPM
Prostate	190.8 nTPM
Placenta	136.0 nTPM
Ovary	95.2 nTPM
Skin	85.5 nTPM
Breast	62.7 nTPM
Heart muscle	62.0 nTPM
Lung	49.2 nTPM
Adipose tissue	45.3 nTPM
Skeletal muscle	42.2 nTPM
Esophagus	35.7 nTPM
Stomach	35.6 nTPM

Intestinal goblet cells	158.3 nTPM
Colon	223.7 nTPM
Rectum	136.8 nTPM
Small intestine	114.3 nTPM

Macrophages	66.1 nTPM
Kidney	132.4 nTPM
Pancreas	127.6 nTPM
Prostate	99.7 nTPM
Lung	75.7 nTPM
Testis	72.6 nTPM
Ovary	67.5 nTPM
Breast	65.3 nTPM
Endometrium	60.1 nTPM
Adipose tissue	59.8 nTPM
Stomach	52.7 nTPM
Spleen	51.8 nTPM
Esophagus	47.2 nTPM
Bone marrow	45.0 nTPM
Skeletal muscle	34.0 nTPM
PBMC	0.0 nTPM

Paneth cells	278.5 nTPM
Colon	421.6 nTPM
Rectum	215.0 nTPM
Small intestine	199.0 nTPM

Plasma cells	73.7 nTPM
Spleen	136.3 nTPM
Bone marrow	100.6 nTPM
Stomach	66.9 nTPM
Esophagus	49.4 nTPM
Adipose tissue	15.5 nTPM

Respiratory ciliated cells	157.5 nTPM
Bronchus	236.3 nTPM
Lung	78.7 nTPM

Smooth muscle cells	149.4 nTPM
Bronchus	852.0 nTPM
Pancreas	186.5 nTPM
Prostate	125.1 nTPM
Ovary	89.3 nTPM
Heart muscle	88.7 nTPM
Skin	86.2 nTPM
Breast	50.6 nTPM
Endometrium	48.2 nTPM
Esophagus	41.9 nTPM
Skeletal muscle	41.4 nTPM
Adipose tissue	34.0 nTPM

T-cells	56.3 nTPM
Skin	110.5 nTPM
Prostate	89.9 nTPM
Kidney	78.0 nTPM
PBMC	75.5 nTPM
Liver	72.8 nTPM
Ovary	66.8 nTPM
Colon	63.2 nTPM
Spleen	62.9 nTPM
Lung	50.1 nTPM
Breast	50.1 nTPM
Bone marrow	48.8 nTPM
Endometrium	47.5 nTPM
Stomach	43.2 nTPM
Adipose tissue	43.1 nTPM
Skeletal muscle	28.1 nTPM
Lymph node	20.5 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	231.1 nTPM
Skin	231.1 nTPM

Basal prostatic cells	200.5 nTPM
Prostate	200.5 nTPM

Basal respiratory cells	362.7 nTPM
Bronchus	362.7 nTPM

Basal squamous epithelial cells	65.4 nTPM
Esophagus	65.4 nTPM

Undifferentiated cells	199.5 nTPM
Colon	275.9 nTPM
Rectum	164.4 nTPM
Small intestine	158.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC