Cell line - TMEM255B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM255B
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 255B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	TIME & HUVEC/TERT2 - Endothelial cell function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HMC-1, HUVEC TERT2, PC-3, RPMI-8226, TIME, U-87 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM255B is part of cluster 41 TIME & HUVEC/TERT2 - Endothelial cell function with confidenceⁱ 1
476 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCDC178	Coiled-coil domain containing 178	0.8049	41
ITGA5	Integrin subunit alpha 5	0.7587	41
PHEX	Phosphate regulating endopeptidase homolog X-linked	0.7496	11
ARHGAP22	Rho GTPase activating protein 22	0.7403	10
IGHJ3	Immunoglobulin heavy joining 3	0.7063	41
CAPN2	Calpain 2	0.7032	11
ADAMTSL1	ADAMTS like 1	0.7022	41
PALMD	Palmdelphin	0.7018	41
COL13A1	Collagen type XIII alpha 1 chain	0.7010	41
NRP1	Neuropilin 1	0.6895	10
SERPINE1	Serpin family E member 1	0.6832	41
SH3BGRL3	SH3 domain binding glutamate rich protein like 3	0.6791	11
FOXC2	Forkhead box C2	0.6725	41
SH2B3	SH2B adaptor protein 3	0.6666	11
FAM214B	Family with sequence similarity 214 member B	0.6619	10