Single cell type - MYO1C - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MYO1C
Gene descriptionⁱ Full gene name according to HGNC.	Myosin IC
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MYO1C is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ATP8B1	ATPase phospholipid transporting 8B1	0.6416	53
TRPM4	Transient receptor potential cation channel subfamily M member 4	0.6270	53
MMP15	Matrix metallopeptidase 15	0.6150	53
SLC52A2	Solute carrier family 52 member 2	0.6125	53
BATF2	Basic leucine zipper ATF-like transcription factor 2	0.5971	53
MST1R	Macrophage stimulating 1 receptor	0.5926	53
TOR4A	Torsin family 4 member A	0.5863	53
ERN2	Endoplasmic reticulum to nucleus signaling 2	0.5831	27
ACVRL1	Activin A receptor like type 1	0.5715	53
TMEM44	Transmembrane protein 44	0.5706	53
MGLL	Monoglyceride lipase	0.5489	53
CACFD1	Calcium channel flower domain containing 1	0.5454	53
DCTPP1	DCTP pyrophosphatase 1	0.5439	53
INF2	Inverted formin 2	0.5395	53
TSPAN15	Tetraspanin 15	0.5383	1

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	133.7 nTPM
Breast	138.2 nTPM
Adipose tissue	129.3 nTPM

Alveolar cells type 1	125.0 nTPM
Lung	125.0 nTPM

Alveolar cells type 2	35.9 nTPM
Lung	35.9 nTPM

Astrocytes	5.5 nTPM
Brain	5.5 nTPM

B-cells	20.8 nTPM
Breast	30.7 nTPM
Adipose tissue	30.6 nTPM
Kidney	23.8 nTPM
Colon	22.3 nTPM
Bone marrow	22.1 nTPM
Liver	20.8 nTPM
Spleen	18.7 nTPM
Lymph node	14.2 nTPM
Stomach	13.2 nTPM
PBMC	11.5 nTPM

Dendritic cells	2.5 nTPM
Breast	5.8 nTPM
Adipose tissue	1.8 nTPM
PBMC	0.0 nTPM

Endothelial cells	78.0 nTPM
Skeletal muscle	157.4 nTPM
Heart muscle	117.7 nTPM
Liver	114.7 nTPM
Ovary	114.6 nTPM
Eye	92.2 nTPM
Breast	80.3 nTPM
Esophagus	79.5 nTPM
Endometrium	66.3 nTPM
Skin	54.7 nTPM
Lung	53.0 nTPM
Placenta	51.2 nTPM
Testis	44.8 nTPM
Prostate	34.1 nTPM
Pancreas	30.9 nTPM

Fibroblasts	51.8 nTPM
Adipose tissue	79.9 nTPM
Skin	64.8 nTPM
Skeletal muscle	64.6 nTPM
Ovary	61.4 nTPM
Breast	57.1 nTPM
Stomach	55.0 nTPM
Placenta	50.4 nTPM
Esophagus	40.4 nTPM
Heart muscle	35.6 nTPM
Prostate	34.9 nTPM
Lung	25.7 nTPM

Intestinal goblet cells	111.8 nTPM
Colon	150.8 nTPM
Rectum	99.9 nTPM
Small intestine	84.6 nTPM

Macrophages	16.7 nTPM
Testis	33.7 nTPM
Lung	28.0 nTPM
PBMC	27.3 nTPM
Breast	22.5 nTPM
Endometrium	22.2 nTPM
Skeletal muscle	19.4 nTPM
Esophagus	18.9 nTPM
Pancreas	17.8 nTPM
Adipose tissue	16.7 nTPM
Prostate	15.0 nTPM
Ovary	14.2 nTPM
Stomach	5.9 nTPM
Spleen	3.1 nTPM
Kidney	3.0 nTPM
Bone marrow	2.5 nTPM

Paneth cells	88.7 nTPM
Colon	108.7 nTPM
Rectum	93.5 nTPM
Small intestine	63.8 nTPM

Plasma cells	12.8 nTPM
Stomach	21.4 nTPM
Esophagus	12.3 nTPM
Bone marrow	11.5 nTPM
Adipose tissue	10.3 nTPM
Spleen	8.5 nTPM

Respiratory ciliated cells	12.9 nTPM
Bronchus	18.6 nTPM
Lung	7.3 nTPM

Smooth muscle cells	90.6 nTPM
Adipose tissue	134.8 nTPM
Skeletal muscle	130.5 nTPM
Breast	127.1 nTPM
Ovary	102.0 nTPM
Heart muscle	92.6 nTPM
Esophagus	88.3 nTPM
Pancreas	88.1 nTPM
Skin	80.1 nTPM
Endometrium	73.8 nTPM
Prostate	67.2 nTPM
Bronchus	12.0 nTPM

T-cells	10.0 nTPM
Skin	28.5 nTPM
Prostate	19.0 nTPM
Skeletal muscle	14.7 nTPM
Breast	14.3 nTPM
Endometrium	13.1 nTPM
Esophagus	13.1 nTPM
Colon	9.5 nTPM
Adipose tissue	8.4 nTPM
Stomach	7.5 nTPM
Kidney	6.9 nTPM
Spleen	6.8 nTPM
Ovary	6.7 nTPM
Bone marrow	5.9 nTPM
Liver	4.5 nTPM
Lung	4.5 nTPM
Lymph node	3.7 nTPM
PBMC	3.4 nTPM

Basal keratinocytes	39.8 nTPM
Skin	39.8 nTPM

Basal prostatic cells	38.2 nTPM
Prostate	38.2 nTPM

Basal respiratory cells	27.8 nTPM
Bronchus	27.8 nTPM

Cholangiocytes	48.6 nTPM
Liver	48.6 nTPM

Undifferentiated cells	88.1 nTPM
Colon	130.6 nTPM
Rectum	81.2 nTPM
Small intestine	52.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC