Single cell type - POLR1D - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLR1D
Gene descriptionⁱ Full gene name according to HGNC.	RNA polymerase I and III subunit D
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Metabolic proteins RNA polymerase related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

POLR1D is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1	0.7591	32
EIF3F	Eukaryotic translation initiation factor 3 subunit F	0.6937	32
RPL13	Ribosomal protein L13	0.6830	32
RPL19	Ribosomal protein L19	0.6600	32
RPS3A	Ribosomal protein S3A	0.6088	32
RPL9	Ribosomal protein L9	0.6006	32
RPL35	Ribosomal protein L35	0.6004	32
RPL27	Ribosomal protein L27	0.5879	32
RPS24	Ribosomal protein S24	0.5871	32
RPL18A	Ribosomal protein L18a	0.5828	32
RPL32	Ribosomal protein L32	0.5795	32
RPL14	Ribosomal protein L14	0.5781	32
RPS14	Ribosomal protein S14	0.5686	32
TOMM20	Translocase of outer mitochondrial membrane 20	0.5631	32
RPS3	Ribosomal protein S3	0.5621	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	122.5 nTPM
Breast	156.3 nTPM
Adipose tissue	88.6 nTPM

Alveolar cells type 1	89.8 nTPM
Lung	89.8 nTPM

Alveolar cells type 2	108.8 nTPM
Lung	108.8 nTPM

Astrocytes	13.7 nTPM
Brain	13.7 nTPM

B-cells	147.4 nTPM
PBMC	205.6 nTPM
Colon	185.3 nTPM
Adipose tissue	169.4 nTPM
Liver	160.9 nTPM
Lymph node	145.5 nTPM
Spleen	134.9 nTPM
Breast	131.1 nTPM
Kidney	123.8 nTPM
Bone marrow	112.8 nTPM
Stomach	104.4 nTPM

Basal squamous epithelial cells	385.3 nTPM
Esophagus	385.3 nTPM

Dendritic cells	133.9 nTPM
Breast	144.7 nTPM
Adipose tissue	141.4 nTPM
PBMC	115.6 nTPM

Endothelial cells	111.8 nTPM
Prostate	191.3 nTPM
Breast	147.4 nTPM
Skin	145.2 nTPM
Testis	143.7 nTPM
Esophagus	119.3 nTPM
Ovary	112.2 nTPM
Pancreas	112.0 nTPM
Placenta	110.8 nTPM
Liver	108.3 nTPM
Endometrium	91.2 nTPM
Skeletal muscle	83.9 nTPM
Lung	74.8 nTPM
Heart muscle	71.5 nTPM
Eye	54.2 nTPM

Enteroendocrine cells	124.4 nTPM
Colon	142.1 nTPM
Rectum	106.8 nTPM

Erythroid cells	182.4 nTPM
Liver	208.5 nTPM
Bone marrow	156.4 nTPM

Fibroblasts	100.5 nTPM
Prostate	137.8 nTPM
Adipose tissue	132.4 nTPM
Placenta	120.2 nTPM
Ovary	111.0 nTPM
Breast	108.4 nTPM
Skin	105.6 nTPM
Lung	91.6 nTPM
Esophagus	87.5 nTPM
Stomach	84.6 nTPM
Skeletal muscle	81.3 nTPM
Heart muscle	45.0 nTPM

Intestinal goblet cells	203.5 nTPM
Colon	221.6 nTPM
Rectum	221.2 nTPM
Small intestine	167.6 nTPM

Macrophages	142.5 nTPM
Testis	215.5 nTPM
Prostate	188.0 nTPM
Ovary	183.0 nTPM
Kidney	180.0 nTPM
Adipose tissue	179.3 nTPM
Spleen	177.3 nTPM
Breast	148.3 nTPM
Skeletal muscle	141.3 nTPM
Bone marrow	128.7 nTPM
Esophagus	127.4 nTPM
Endometrium	118.3 nTPM
Lung	111.0 nTPM
Stomach	108.4 nTPM
Pancreas	76.5 nTPM
PBMC	54.6 nTPM

Paneth cells	124.6 nTPM
Rectum	175.5 nTPM
Colon	111.9 nTPM
Small intestine	86.3 nTPM

Plasma cells	105.9 nTPM
Spleen	134.7 nTPM
Stomach	127.6 nTPM
Bone marrow	108.8 nTPM
Adipose tissue	84.4 nTPM
Esophagus	74.0 nTPM

Cholangiocytes	118.7 nTPM
Liver	118.7 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Cytotrophoblasts	155.0 nTPM
Placenta	155.0 nTPM

Respiratory ciliated cells	58.5 nTPM
Bronchus	66.0 nTPM
Lung	51.0 nTPM

Smooth muscle cells	164.4 nTPM
Bronchus	692.2 nTPM
Prostate	167.3 nTPM
Breast	135.5 nTPM
Pancreas	135.2 nTPM
Ovary	131.1 nTPM
Skin	112.7 nTPM
Adipose tissue	100.5 nTPM
Esophagus	93.1 nTPM
Endometrium	88.7 nTPM
Skeletal muscle	86.9 nTPM
Heart muscle	65.7 nTPM

T-cells	148.5 nTPM
PBMC	265.0 nTPM
Ovary	191.3 nTPM
Adipose tissue	187.3 nTPM
Lymph node	180.1 nTPM
Breast	176.5 nTPM
Liver	168.9 nTPM
Skin	164.9 nTPM
Colon	164.4 nTPM
Prostate	137.3 nTPM
Kidney	136.2 nTPM
Spleen	130.8 nTPM
Skeletal muscle	120.4 nTPM
Endometrium	112.0 nTPM
Stomach	108.2 nTPM
Bone marrow	105.4 nTPM
Lung	91.1 nTPM
Esophagus	85.2 nTPM

Undifferentiated cells	197.2 nTPM
Colon	203.1 nTPM
Small intestine	198.8 nTPM
Rectum	189.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC