Single cell type - RPS19BP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPS19BP1
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal protein S19 binding protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RPS19BP1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ARL6IP4	ADP ribosylation factor like GTPase 6 interacting protein 4	0.6409	39
IMP4	IMP U3 small nucleolar ribonucleoprotein 4	0.5896	39
SDHAF1	Succinate dehydrogenase complex assembly factor 1	0.5796	32
STUB1	STIP1 homology and U-box containing protein 1	0.5645	39
SSNA1	SS nuclear autoantigen 1	0.5637	53
TSR3	TSR3 ribosome maturation factor	0.5608	67
SURF1	SURF1 cytochrome c oxidase assembly factor	0.5280	39
RALY	RALY heterogeneous nuclear ribonucleoprotein	0.5240	53
POLE4	DNA polymerase epsilon 4, accessory subunit	0.5213	39
PRELID1	PRELI domain containing 1	0.5193	16
NAA10	N-alpha-acetyltransferase 10, NatA catalytic subunit	0.5039	39
TMEM230	Transmembrane protein 230	0.4987	39
WDR45	WD repeat domain 45	0.4986	67
DRG2	Developmentally regulated GTP binding protein 2	0.4967	39
APRT	Adenine phosphoribosyltransferase	0.4940	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	113.6 nTPM
Breast	156.5 nTPM
Adipose tissue	70.8 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	51.4 nTPM
Lung	51.4 nTPM

Astrocytes	13.1 nTPM
Brain	13.1 nTPM

B-cells	109.5 nTPM
Liver	246.0 nTPM
Breast	168.6 nTPM
Kidney	128.5 nTPM
Colon	100.6 nTPM
PBMC	95.7 nTPM
Spleen	91.1 nTPM
Lymph node	77.2 nTPM
Stomach	70.3 nTPM
Bone marrow	61.3 nTPM
Adipose tissue	56.1 nTPM

Dendritic cells	114.7 nTPM
Breast	161.8 nTPM
Adipose tissue	118.5 nTPM
PBMC	63.8 nTPM

Endothelial cells	121.0 nTPM
Pancreas	227.8 nTPM
Prostate	167.6 nTPM
Liver	162.3 nTPM
Breast	159.1 nTPM
Testis	155.0 nTPM
Skin	152.9 nTPM
Placenta	139.3 nTPM
Ovary	117.0 nTPM
Esophagus	99.9 nTPM
Endometrium	71.2 nTPM
Heart muscle	69.0 nTPM
Eye	67.2 nTPM
Skeletal muscle	65.9 nTPM
Lung	40.6 nTPM

Enteroendocrine cells	142.6 nTPM
Colon	149.2 nTPM
Rectum	135.9 nTPM

Fibroblasts	92.0 nTPM
Breast	123.8 nTPM
Ovary	122.1 nTPM
Skin	118.5 nTPM
Prostate	113.1 nTPM
Placenta	103.1 nTPM
Adipose tissue	99.3 nTPM
Heart muscle	98.1 nTPM
Esophagus	83.3 nTPM
Skeletal muscle	69.8 nTPM
Stomach	52.0 nTPM
Lung	29.0 nTPM

Intestinal goblet cells	207.5 nTPM
Colon	330.2 nTPM
Small intestine	166.2 nTPM
Rectum	126.2 nTPM

Macrophages	110.8 nTPM
Pancreas	275.6 nTPM
Kidney	185.3 nTPM
Prostate	137.5 nTPM
Ovary	136.8 nTPM
Breast	124.0 nTPM
PBMC	109.1 nTPM
Testis	106.4 nTPM
Endometrium	93.3 nTPM
Spleen	85.0 nTPM
Lung	75.7 nTPM
Stomach	73.3 nTPM
Bone marrow	71.2 nTPM
Adipose tissue	67.4 nTPM
Skeletal muscle	65.2 nTPM
Esophagus	56.6 nTPM

Paneth cells	202.2 nTPM
Colon	283.3 nTPM
Small intestine	176.5 nTPM
Rectum	146.9 nTPM

Plasma cells	193.3 nTPM
Spleen	258.8 nTPM
Esophagus	252.6 nTPM
Stomach	195.9 nTPM
Bone marrow	169.7 nTPM
Adipose tissue	89.6 nTPM

Respiratory ciliated cells	54.0 nTPM
Bronchus	70.2 nTPM
Lung	37.9 nTPM

Smooth muscle cells	100.9 nTPM
Pancreas	232.8 nTPM
Breast	130.8 nTPM
Prostate	123.8 nTPM
Ovary	120.5 nTPM
Skin	110.9 nTPM
Esophagus	71.3 nTPM
Skeletal muscle	70.2 nTPM
Heart muscle	69.3 nTPM
Adipose tissue	65.5 nTPM
Endometrium	63.1 nTPM
Bronchus	51.5 nTPM

Basal keratinocytes	137.1 nTPM
Skin	137.1 nTPM

Basal prostatic cells	94.3 nTPM
Prostate	94.3 nTPM

Basal respiratory cells	124.3 nTPM
Bronchus	124.3 nTPM

Basal squamous epithelial cells	84.2 nTPM
Esophagus	84.2 nTPM

T-cells	115.2 nTPM
Ovary	182.4 nTPM
Liver	175.6 nTPM
Colon	154.4 nTPM
Prostate	151.5 nTPM
Kidney	146.5 nTPM
Skin	134.9 nTPM
Breast	130.2 nTPM
PBMC	115.4 nTPM
Stomach	98.4 nTPM
Spleen	97.7 nTPM
Esophagus	91.7 nTPM
Endometrium	89.7 nTPM
Bone marrow	87.3 nTPM
Adipose tissue	85.3 nTPM
Skeletal muscle	85.1 nTPM
Lymph node	77.9 nTPM
Lung	54.6 nTPM

Undifferentiated cells	165.9 nTPM
Colon	220.6 nTPM
Small intestine	147.2 nTPM
Rectum	129.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC