Single cell type - RRP7A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RRP7A
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal RNA processing 7 homolog A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes - Immune response regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RRP7A is part of cluster 3 Monocytes - Immune response regulation with confidenceⁱ 0.77
114 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DOHH	Deoxyhypusine hydroxylase	0.5309	39
YDJC	YdjC chitooligosaccharide deacetylase homolog	0.5278	1
SLC35A4	Solute carrier family 35 member A4	0.5275	25
TRAF2	TNF receptor associated factor 2	0.5159	3
DBNL	Drebrin like	0.4967	3
ADPGK	ADP dependent glucokinase	0.4857	3
EBI3	Epstein-Barr virus induced 3	0.4640	38
POLR2E	RNA polymerase II, I and III subunit E	0.4599	3
ARPC4	Actin related protein 2/3 complex subunit 4	0.4593	3
NCAPH2	Non-SMC condensin II complex subunit H2	0.4572	12
GMPPB	GDP-mannose pyrophosphorylase B	0.4569	55
KXD1	KxDL motif containing 1	0.4534	29
IFRD2	Interferon related developmental regulator 2	0.4500	39
STX5	Syntaxin 5	0.4498	22
GEMIN7	Gem nuclear organelle associated protein 7	0.4496	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.2 nTPM
Breast	40.1 nTPM
Adipose tissue	24.4 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	36.6 nTPM
Lung	36.6 nTPM

Astrocytes	5.9 nTPM
Brain	5.9 nTPM

B-cells	48.6 nTPM
Liver	86.5 nTPM
PBMC	72.9 nTPM
Colon	65.5 nTPM
Stomach	48.6 nTPM
Kidney	47.6 nTPM
Adipose tissue	46.7 nTPM
Bone marrow	42.5 nTPM
Spleen	36.0 nTPM
Breast	22.8 nTPM
Lymph node	17.4 nTPM

Dendritic cells	50.3 nTPM
PBMC	87.6 nTPM
Adipose tissue	33.6 nTPM
Breast	29.5 nTPM

Endothelial cells	38.6 nTPM
Placenta	64.8 nTPM
Prostate	51.2 nTPM
Ovary	49.5 nTPM
Skin	46.8 nTPM
Liver	42.2 nTPM
Eye	41.2 nTPM
Lung	40.6 nTPM
Pancreas	38.6 nTPM
Testis	32.0 nTPM
Breast	31.1 nTPM
Skeletal muscle	30.8 nTPM
Endometrium	24.8 nTPM
Heart muscle	24.1 nTPM
Esophagus	23.2 nTPM

Fibroblasts	31.0 nTPM
Ovary	76.1 nTPM
Placenta	46.5 nTPM
Prostate	40.9 nTPM
Skin	27.1 nTPM
Skeletal muscle	25.3 nTPM
Stomach	25.3 nTPM
Adipose tissue	25.2 nTPM
Breast	21.9 nTPM
Lung	21.2 nTPM
Esophagus	18.9 nTPM
Heart muscle	13.1 nTPM

Intestinal goblet cells	39.8 nTPM
Colon	54.3 nTPM
Small intestine	33.0 nTPM
Rectum	32.1 nTPM

Macrophages	39.5 nTPM
Pancreas	76.5 nTPM
Kidney	70.4 nTPM
Prostate	65.4 nTPM
Ovary	64.6 nTPM
Lung	39.9 nTPM
Endometrium	37.2 nTPM
Testis	35.5 nTPM
Stomach	35.1 nTPM
Skeletal muscle	33.9 nTPM
Breast	33.6 nTPM
Adipose tissue	33.0 nTPM
Bone marrow	30.0 nTPM
Spleen	22.8 nTPM
Esophagus	14.2 nTPM
PBMC	0.0 nTPM

Paneth cells	46.0 nTPM
Colon	52.6 nTPM
Small intestine	45.0 nTPM
Rectum	40.4 nTPM

Plasma cells	51.4 nTPM
Bone marrow	72.5 nTPM
Spleen	63.7 nTPM
Esophagus	55.5 nTPM
Adipose tissue	34.2 nTPM
Stomach	31.0 nTPM

Respiratory ciliated cells	34.4 nTPM
Lung	37.9 nTPM
Bronchus	30.9 nTPM

Smooth muscle cells	37.0 nTPM
Pancreas	138.3 nTPM
Ovary	43.8 nTPM
Prostate	39.7 nTPM
Skeletal muscle	32.2 nTPM
Breast	28.8 nTPM
Skin	26.2 nTPM
Heart muscle	24.5 nTPM
Bronchus	22.6 nTPM
Endometrium	20.0 nTPM
Adipose tissue	17.0 nTPM
Esophagus	14.0 nTPM

T-cells	40.2 nTPM
Colon	78.9 nTPM
PBMC	78.7 nTPM
Kidney	60.2 nTPM
Ovary	48.9 nTPM
Liver	45.8 nTPM
Stomach	43.9 nTPM
Bone marrow	43.1 nTPM
Prostate	42.6 nTPM
Adipose tissue	40.5 nTPM
Breast	33.3 nTPM
Endometrium	31.8 nTPM
Spleen	31.8 nTPM
Skeletal muscle	30.9 nTPM
Skin	27.1 nTPM
Lung	21.3 nTPM
Lymph node	17.3 nTPM
Esophagus	6.6 nTPM

Basal prostatic cells	95.1 nTPM
Prostate	95.1 nTPM

Basal respiratory cells	41.4 nTPM
Bronchus	41.4 nTPM

Basal squamous epithelial cells	12.5 nTPM
Esophagus	12.5 nTPM

Cholangiocytes	31.5 nTPM
Liver	31.5 nTPM

Undifferentiated cells	59.4 nTPM
Colon	91.0 nTPM
Small intestine	50.1 nTPM
Rectum	37.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC