Single cell type - ZMYM1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZMYM1
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger MYM-type containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZMYM1 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 0.98
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ANGEL2	Angel homolog 2	0.5921	59
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2	0.5866	52
ZNF260	Zinc finger protein 260	0.5717	59
PCED1A	PC-esterase domain containing 1A	0.5560	36
ALG11	ALG11 alpha-1,2-mannosyltransferase	0.5555	59
TRIM23	Tripartite motif containing 23	0.5407	59
UTP20	UTP20 small subunit processome component	0.5379	59
ZCCHC4	Zinc finger CCHC-type containing 4	0.5368	59
KLHL9	Kelch like family member 9	0.5331	43
TGS1	Trimethylguanosine synthase 1	0.5250	59
PRKDC	Protein kinase, DNA-activated, catalytic subunit	0.5237	36
PLCG1	Phospholipase C gamma 1	0.5233	58
GTF2H3	General transcription factor IIH subunit 3	0.5231	59
PCDHGB5	Protocadherin gamma subfamily B, 5	0.5195	50
ZFP90	ZFP90 zinc finger protein	0.5176	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.4 nTPM
Breast	18.0 nTPM
Adipose tissue	14.8 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	8.9 nTPM
Lung	8.9 nTPM

Astrocytes	16.6 nTPM
Brain	16.6 nTPM

B-cells	9.2 nTPM
Bone marrow	23.7 nTPM
Stomach	15.9 nTPM
Lymph node	12.0 nTPM
Spleen	10.4 nTPM
Colon	6.4 nTPM
Adipose tissue	6.0 nTPM
Breast	5.3 nTPM
Kidney	4.8 nTPM
Liver	4.1 nTPM
PBMC	2.8 nTPM

Dendritic cells	9.5 nTPM
Breast	11.3 nTPM
Adipose tissue	9.1 nTPM
PBMC	8.0 nTPM

Endothelial cells	10.3 nTPM
Heart muscle	21.8 nTPM
Lung	18.7 nTPM
Esophagus	13.3 nTPM
Endometrium	13.0 nTPM
Breast	12.1 nTPM
Testis	10.4 nTPM
Skeletal muscle	10.4 nTPM
Eye	9.7 nTPM
Ovary	9.2 nTPM
Liver	7.3 nTPM
Prostate	5.9 nTPM
Skin	4.1 nTPM
Placenta	4.0 nTPM
Pancreas	3.9 nTPM

Fibroblasts	11.4 nTPM
Adipose tissue	18.6 nTPM
Esophagus	16.9 nTPM
Breast	16.4 nTPM
Skeletal muscle	16.0 nTPM
Stomach	14.9 nTPM
Ovary	11.4 nTPM
Heart muscle	10.0 nTPM
Lung	6.7 nTPM
Placenta	5.9 nTPM
Prostate	4.6 nTPM
Skin	4.3 nTPM

Intestinal goblet cells	3.5 nTPM
Rectum	4.1 nTPM
Small intestine	3.5 nTPM
Colon	2.9 nTPM

Macrophages	7.6 nTPM
Bone marrow	20.0 nTPM
Esophagus	17.3 nTPM
Endometrium	10.3 nTPM
Breast	9.3 nTPM
Lung	9.2 nTPM
Ovary	8.8 nTPM
Spleen	7.2 nTPM
Adipose tissue	6.8 nTPM
Skeletal muscle	6.0 nTPM
Stomach	5.9 nTPM
Prostate	4.6 nTPM
Testis	4.0 nTPM
Pancreas	2.5 nTPM
Kidney	1.5 nTPM
PBMC	0.0 nTPM

Paneth cells	0.8 nTPM
Rectum	2.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	6.6 nTPM
Esophagus	12.3 nTPM
Adipose tissue	7.8 nTPM
Stomach	5.7 nTPM
Spleen	4.0 nTPM
Bone marrow	3.3 nTPM

Respiratory ciliated cells	8.6 nTPM
Lung	8.7 nTPM
Bronchus	8.4 nTPM

Smooth muscle cells	9.9 nTPM
Esophagus	21.7 nTPM
Endometrium	16.2 nTPM
Breast	14.4 nTPM
Adipose tissue	13.1 nTPM
Ovary	12.0 nTPM
Skeletal muscle	9.2 nTPM
Heart muscle	6.1 nTPM
Bronchus	5.7 nTPM
Pancreas	5.0 nTPM
Skin	3.1 nTPM
Prostate	2.2 nTPM

T-cells	10.1 nTPM
Bone marrow	22.4 nTPM
Lymph node	17.6 nTPM
PBMC	14.0 nTPM
Lung	13.6 nTPM
Esophagus	13.1 nTPM
Spleen	12.3 nTPM
Stomach	11.8 nTPM
Ovary	11.1 nTPM
Skeletal muscle	10.5 nTPM
Breast	10.2 nTPM
Adipose tissue	8.7 nTPM
Kidney	8.2 nTPM
Endometrium	7.6 nTPM
Liver	5.6 nTPM
Skin	3.3 nTPM
Colon	2.4 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	1.7 nTPM
Skin	1.7 nTPM

Basal respiratory cells	11.2 nTPM
Bronchus	11.2 nTPM

Basal squamous epithelial cells	19.9 nTPM
Esophagus	19.9 nTPM

Collecting duct cells	14.7 nTPM
Kidney	14.7 nTPM

Undifferentiated cells	4.5 nTPM
Small intestine	5.4 nTPM
Rectum	4.3 nTPM
Colon	3.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC