Single cell type - ZNF181 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF181
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 181
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZNF181 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TRIP11	Thyroid hormone receptor interactor 11	0.6134	52
ZNF302	Zinc finger protein 302	0.5995	52
CASP8AP2	Caspase 8 associated protein 2	0.5457	52
IGFN1	Immunoglobulin like and fibronectin type III domain containing 1	0.5357	50
ZBED8	Zinc finger BED-type containing 8	0.5264	52
ZNF347	Zinc finger protein 347	0.5127	52
POU4F1	POU class 4 homeobox 1	0.5110	50
ZNF527	Zinc finger protein 527	0.5063	52
PCDHGB7	Protocadherin gamma subfamily B, 7	0.5059	50
LBX1	Ladybird homeobox 1	0.4894	50
SCN7A	Sodium voltage-gated channel alpha subunit 7	0.4874	50
ZNF383	Zinc finger protein 383	0.4867	52
AC010522.1	Novel protein	0.4852	43
SERF1B	Small EDRK-rich factor 1B	0.4847	43
CHRNA1	Cholinergic receptor nicotinic alpha 1 subunit	0.4844	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.5 nTPM
Breast	14.9 nTPM
Adipose tissue	8.0 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	5.3 nTPM
Lung	5.3 nTPM

Astrocytes	8.5 nTPM
Brain	8.5 nTPM

B-cells	5.7 nTPM
PBMC	12.9 nTPM
Bone marrow	11.5 nTPM
Stomach	7.7 nTPM
Lymph node	6.6 nTPM
Colon	4.8 nTPM
Spleen	4.2 nTPM
Breast	4.0 nTPM
Liver	2.8 nTPM
Adipose tissue	2.5 nTPM
Kidney	0.0 nTPM

Dendritic cells	3.1 nTPM
Adipose tissue	5.2 nTPM
Breast	4.0 nTPM
PBMC	0.0 nTPM

Endothelial cells	8.9 nTPM
Heart muscle	26.4 nTPM
Skeletal muscle	13.0 nTPM
Esophagus	10.9 nTPM
Breast	10.8 nTPM
Testis	9.5 nTPM
Lung	9.3 nTPM
Endometrium	8.5 nTPM
Pancreas	7.7 nTPM
Ovary	7.4 nTPM
Eye	6.5 nTPM
Prostate	4.7 nTPM
Liver	4.6 nTPM
Skin	3.6 nTPM
Placenta	1.7 nTPM

Fibroblasts	11.2 nTPM
Heart muscle	43.8 nTPM
Breast	14.4 nTPM
Esophagus	14.2 nTPM
Skeletal muscle	13.1 nTPM
Adipose tissue	7.5 nTPM
Stomach	7.4 nTPM
Ovary	6.4 nTPM
Lung	5.6 nTPM
Placenta	4.3 nTPM
Prostate	3.4 nTPM
Skin	3.4 nTPM

Intestinal goblet cells	6.5 nTPM
Rectum	8.2 nTPM
Colon	6.5 nTPM
Small intestine	4.7 nTPM

Macrophages	3.3 nTPM
Lung	10.1 nTPM
Testis	6.9 nTPM
Breast	5.7 nTPM
Ovary	4.7 nTPM
Prostate	4.6 nTPM
Skeletal muscle	3.8 nTPM
Esophagus	3.1 nTPM
Kidney	3.0 nTPM
Bone marrow	2.5 nTPM
Adipose tissue	2.3 nTPM
Endometrium	2.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	4.6 nTPM
Small intestine	7.5 nTPM
Rectum	6.3 nTPM
Colon	0.0 nTPM

Plasma cells	2.6 nTPM
Stomach	6.9 nTPM
Bone marrow	3.3 nTPM
Adipose tissue	1.9 nTPM
Spleen	1.0 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	14.5 nTPM
Lung	26.2 nTPM
Bronchus	2.8 nTPM

Smooth muscle cells	14.6 nTPM
Heart muscle	45.0 nTPM
Esophagus	24.8 nTPM
Skeletal muscle	17.5 nTPM
Breast	16.2 nTPM
Skin	13.9 nTPM
Adipose tissue	10.4 nTPM
Ovary	10.2 nTPM
Endometrium	7.9 nTPM
Prostate	7.5 nTPM
Pancreas	5.2 nTPM
Bronchus	2.0 nTPM

T-cells	6.2 nTPM
PBMC	14.2 nTPM
Lung	9.1 nTPM
Ovary	8.9 nTPM
Lymph node	8.2 nTPM
Bone marrow	7.6 nTPM
Kidney	7.5 nTPM
Breast	7.2 nTPM
Esophagus	6.6 nTPM
Colon	6.2 nTPM
Spleen	5.5 nTPM
Skeletal muscle	5.4 nTPM
Liver	5.3 nTPM
Adipose tissue	3.9 nTPM
Stomach	3.8 nTPM
Endometrium	3.7 nTPM
Skin	1.9 nTPM
Prostate	0.0 nTPM

Distal tubular cells	17.6 nTPM
Kidney	17.6 nTPM

Endometrial stromal cells	7.3 nTPM
Endometrium	7.3 nTPM

Excitatory neurons	6.8 nTPM
Brain	6.8 nTPM

Exocrine glandular cells	4.9 nTPM
Pancreas	4.9 nTPM

Undifferentiated cells	4.4 nTPM
Small intestine	6.0 nTPM
Rectum	5.2 nTPM
Colon	2.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC