Single cell type - TRIP11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIP11
Gene descriptionⁱ Full gene name according to HGNC.	Thyroid hormone receptor interactor 11
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRIP11 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CASP8AP2	Caspase 8 associated protein 2	0.6323	52
ZNF181	Zinc finger protein 181	0.6134	50
GTF3C3	General transcription factor IIIC subunit 3	0.5945	52
MIA3	MIA SH3 domain ER export factor 3	0.5941	52
TTC37	Tetratricopeptide repeat domain 37	0.5416	52
ZNF347	Zinc finger protein 347	0.5360	52
ZC3H13	Zinc finger CCCH-type containing 13	0.5356	10
ESCO1	Establishment of sister chromatid cohesion N-acetyltransferase 1	0.5196	52
NOL8	Nucleolar protein 8	0.5188	52
PHF3	PHD finger protein 3	0.5030	52
PRR14L	Proline rich 14 like	0.5015	52
ZNF182	Zinc finger protein 182	0.4981	40
NKTR	Natural killer cell triggering receptor	0.4964	52
KIAA2026	KIAA2026	0.4937	52
GOLGB1	Golgin B1	0.4929	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	66.8 nTPM
Breast	68.6 nTPM
Adipose tissue	65.0 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Alveolar cells type 2	79.8 nTPM
Lung	79.8 nTPM

Astrocytes	57.5 nTPM
Brain	57.5 nTPM

B-cells	32.5 nTPM
Breast	64.1 nTPM
PBMC	47.1 nTPM
Adipose tissue	34.5 nTPM
Liver	30.6 nTPM
Colon	30.3 nTPM
Stomach	28.2 nTPM
Lymph node	24.0 nTPM
Kidney	23.8 nTPM
Bone marrow	22.9 nTPM
Spleen	19.4 nTPM

Dendritic cells	41.4 nTPM
PBMC	51.8 nTPM
Breast	41.6 nTPM
Adipose tissue	30.7 nTPM

Endothelial cells	53.9 nTPM
Heart muscle	111.9 nTPM
Skeletal muscle	76.8 nTPM
Ovary	74.5 nTPM
Endometrium	74.2 nTPM
Pancreas	61.8 nTPM
Testis	52.4 nTPM
Lung	49.9 nTPM
Breast	47.8 nTPM
Eye	44.5 nTPM
Prostate	43.9 nTPM
Liver	37.6 nTPM
Placenta	31.8 nTPM
Esophagus	30.0 nTPM
Skin	16.8 nTPM

Fibroblasts	51.7 nTPM
Heart muscle	112.5 nTPM
Skeletal muscle	78.8 nTPM
Lung	68.2 nTPM
Adipose tissue	63.0 nTPM
Breast	56.5 nTPM
Ovary	55.2 nTPM
Placenta	35.5 nTPM
Prostate	35.0 nTPM
Esophagus	33.1 nTPM
Skin	18.6 nTPM
Stomach	11.9 nTPM

Intestinal goblet cells	40.4 nTPM
Colon	44.3 nTPM
Rectum	42.6 nTPM
Small intestine	34.2 nTPM

Macrophages	30.4 nTPM
Lung	57.4 nTPM
Ovary	54.7 nTPM
Breast	43.8 nTPM
Skeletal muscle	38.3 nTPM
Endometrium	37.2 nTPM
Testis	31.4 nTPM
Spleen	30.0 nTPM
Adipose tissue	26.8 nTPM
Bone marrow	26.2 nTPM
Pancreas	25.5 nTPM
Prostate	20.7 nTPM
Kidney	18.9 nTPM
Esophagus	17.3 nTPM
Stomach	14.7 nTPM
PBMC	13.6 nTPM

Paneth cells	29.5 nTPM
Rectum	35.4 nTPM
Small intestine	30.0 nTPM
Colon	23.1 nTPM

Plasma cells	26.3 nTPM
Adipose tissue	48.3 nTPM
Stomach	30.1 nTPM
Spleen	26.1 nTPM
Bone marrow	14.8 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	56.4 nTPM
Lung	77.3 nTPM
Bronchus	35.5 nTPM

Smooth muscle cells	50.4 nTPM
Heart muscle	103.5 nTPM
Ovary	68.4 nTPM
Endometrium	68.1 nTPM
Skeletal muscle	67.7 nTPM
Breast	56.4 nTPM
Adipose tissue	49.8 nTPM
Pancreas	44.4 nTPM
Esophagus	32.5 nTPM
Prostate	26.5 nTPM
Skin	18.8 nTPM
Bronchus	17.8 nTPM

T-cells	30.2 nTPM
Skeletal muscle	62.2 nTPM
PBMC	54.6 nTPM
Endometrium	47.7 nTPM
Breast	47.6 nTPM
Lung	39.5 nTPM
Ovary	31.1 nTPM
Adipose tissue	29.6 nTPM
Kidney	24.7 nTPM
Liver	23.4 nTPM
Lymph node	23.1 nTPM
Colon	22.8 nTPM
Bone marrow	22.3 nTPM
Esophagus	19.7 nTPM
Prostate	19.0 nTPM
Spleen	18.7 nTPM
Skin	15.2 nTPM
Stomach	12.4 nTPM

Basal keratinocytes	16.6 nTPM
Skin	16.6 nTPM

Basal respiratory cells	31.7 nTPM
Bronchus	31.7 nTPM

Basal squamous epithelial cells	21.6 nTPM
Esophagus	21.6 nTPM

Cholangiocytes	34.3 nTPM
Liver	34.3 nTPM

Undifferentiated cells	32.9 nTPM
Rectum	38.3 nTPM
Colon	31.9 nTPM
Small intestine	28.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC