Single cell type - MPZL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPZL1
Gene descriptionⁱ Full gene name according to HGNC.	Myelin protein zero like 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MPZL1 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MTCH1	Mitochondrial carrier 1	0.5840	54
KCNK15	Potassium two pore domain channel subfamily K member 15	0.5232	50
CMTM8	CKLF like MARVEL transmembrane domain containing 8	0.5186	40
SLC35C2	Solute carrier family 35 member C2	0.5117	47
RHOBTB3	Rho related BTB domain containing 3	0.5075	40
KDSR	3-ketodihydrosphingosine reductase	0.4936	22
FBLN1	Fibulin 1	0.4842	50
PXDC1	PX domain containing 1	0.4814	50
TRIP10	Thyroid hormone receptor interactor 10	0.4700	3
UAP1	UDP-N-acetylglucosamine pyrophosphorylase 1	0.4685	50
SLC39A1	Solute carrier family 39 member 1	0.4616	47
ASAP3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	0.4533	40
SLC39A7	Solute carrier family 39 member 7	0.4523	27
TMED3	Transmembrane p24 trafficking protein 3	0.4487	55
OSMR	Oncostatin M receptor	0.4463	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	52.9 nTPM
Breast	53.8 nTPM
Adipose tissue	52.1 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	30.0 nTPM
Lung	30.0 nTPM

Astrocytes	31.0 nTPM
Brain	31.0 nTPM

B-cells	15.1 nTPM
Breast	29.4 nTPM
Kidney	28.5 nTPM
Liver	28.3 nTPM
Colon	14.4 nTPM
Stomach	12.7 nTPM
Lymph node	8.9 nTPM
Spleen	7.6 nTPM
Bone marrow	7.4 nTPM
PBMC	7.1 nTPM
Adipose tissue	6.6 nTPM

Dendritic cells	21.1 nTPM
PBMC	51.8 nTPM
Breast	8.1 nTPM
Adipose tissue	3.4 nTPM

Endothelial cells	56.7 nTPM
Pancreas	181.5 nTPM
Prostate	127.4 nTPM
Ovary	93.8 nTPM
Heart muscle	55.6 nTPM
Breast	47.4 nTPM
Placenta	45.5 nTPM
Skin	42.3 nTPM
Skeletal muscle	37.5 nTPM
Endometrium	34.2 nTPM
Eye	32.4 nTPM
Testis	29.9 nTPM
Lung	24.9 nTPM
Esophagus	21.6 nTPM
Liver	20.2 nTPM

Fibroblasts	118.2 nTPM
Prostate	363.9 nTPM
Adipose tissue	145.2 nTPM
Heart muscle	136.1 nTPM
Esophagus	118.1 nTPM
Skeletal muscle	103.3 nTPM
Skin	93.1 nTPM
Breast	82.4 nTPM
Stomach	74.3 nTPM
Placenta	70.7 nTPM
Lung	68.2 nTPM
Ovary	45.4 nTPM

Intestinal goblet cells	39.7 nTPM
Rectum	56.1 nTPM
Small intestine	38.8 nTPM
Colon	24.3 nTPM

Macrophages	23.5 nTPM
Prostate	68.8 nTPM
Pancreas	48.5 nTPM
Ovary	34.1 nTPM
Spleen	29.0 nTPM
Bone marrow	22.5 nTPM
Endometrium	21.9 nTPM
Breast	20.2 nTPM
Lung	19.1 nTPM
Testis	18.0 nTPM
Adipose tissue	16.5 nTPM
Skeletal muscle	15.4 nTPM
Kidney	14.3 nTPM
Esophagus	12.6 nTPM
Stomach	11.7 nTPM
PBMC	0.0 nTPM

Paneth cells	41.6 nTPM
Rectum	65.6 nTPM
Colon	32.9 nTPM
Small intestine	26.3 nTPM

Plasma cells	23.5 nTPM
Spleen	34.7 nTPM
Stomach	33.5 nTPM
Esophagus	30.7 nTPM
Bone marrow	9.9 nTPM
Adipose tissue	8.4 nTPM

Respiratory ciliated cells	28.3 nTPM
Bronchus	33.3 nTPM
Lung	23.3 nTPM

Smooth muscle cells	48.6 nTPM
Pancreas	142.0 nTPM
Prostate	101.9 nTPM
Ovary	62.4 nTPM
Adipose tissue	44.0 nTPM
Skin	39.0 nTPM
Heart muscle	37.5 nTPM
Endometrium	28.7 nTPM
Breast	27.5 nTPM
Skeletal muscle	23.6 nTPM
Bronchus	16.8 nTPM
Esophagus	10.9 nTPM

T-cells	8.6 nTPM
Prostate	42.6 nTPM
Skin	20.7 nTPM
Esophagus	13.1 nTPM
Endometrium	10.7 nTPM
Breast	8.9 nTPM
Ovary	6.7 nTPM
Lung	6.1 nTPM
Colon	5.7 nTPM
Lymph node	4.9 nTPM
Skeletal muscle	4.7 nTPM
Liver	4.1 nTPM
Adipose tissue	3.6 nTPM
PBMC	3.5 nTPM
Spleen	3.3 nTPM
Kidney	2.7 nTPM
Bone marrow	2.5 nTPM
Stomach	2.3 nTPM

Basal keratinocytes	76.3 nTPM
Skin	76.3 nTPM

Basal prostatic cells	78.5 nTPM
Prostate	78.5 nTPM

Basal respiratory cells	57.6 nTPM
Bronchus	57.6 nTPM

Basal squamous epithelial cells	35.9 nTPM
Esophagus	35.9 nTPM

Undifferentiated cells	61.0 nTPM
Rectum	73.9 nTPM
Colon	57.3 nTPM
Small intestine	51.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC