Single cell type - KDSR - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KDSR
Gene descriptionⁱ Full gene name according to HGNC.	3-ketodihydrosphingosine reductase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KDSR is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MYC	MYC proto-oncogene, bHLH transcription factor	0.7003	61
PXDC1	PX domain containing 1	0.6221	50
PHLDA1	Pleckstrin homology like domain family A member 1	0.5946	22
CEBPD	CCAAT enhancer binding protein delta	0.5811	41
ERRFI1	ERBB receptor feedback inhibitor 1	0.5505	22
ZFP36L1	ZFP36 ring finger protein like 1	0.5437	61
ALKBH2	AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase	0.5335	39
FGFR1	Fibroblast growth factor receptor 1	0.5333	50
TGIF1	TGFB induced factor homeobox 1	0.5311	22
TNS4	Tensin 4	0.5211	61
RPLP1	Ribosomal protein lateral stalk subunit P1	0.5129	32
TMEM43	Transmembrane protein 43	0.5083	50
HAS2	Hyaluronan synthase 2	0.5069	50
FOSL1	FOS like 1, AP-1 transcription factor subunit	0.5005	22
ZXDB	Zinc finger X-linked duplicated B	0.4969	28

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	53.1 nTPM
Adipose tissue	58.4 nTPM
Breast	47.7 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	49.1 nTPM
Lung	49.1 nTPM

Astrocytes	21.9 nTPM
Brain	21.9 nTPM

B-cells	30.1 nTPM
Kidney	57.1 nTPM
Colon	41.5 nTPM
Adipose tissue	40.7 nTPM
Breast	28.1 nTPM
Stomach	25.0 nTPM
Lymph node	24.3 nTPM
Bone marrow	23.7 nTPM
Spleen	22.5 nTPM
Liver	19.6 nTPM
PBMC	18.6 nTPM

Basal squamous epithelial cells	122.3 nTPM
Esophagus	122.3 nTPM

Dendritic cells	15.6 nTPM
Adipose tissue	18.0 nTPM
Breast	16.8 nTPM
PBMC	12.0 nTPM

Endothelial cells	48.1 nTPM
Prostate	75.1 nTPM
Esophagus	74.9 nTPM
Liver	73.4 nTPM
Endometrium	71.2 nTPM
Skin	67.3 nTPM
Skeletal muscle	51.3 nTPM
Testis	45.9 nTPM
Breast	42.6 nTPM
Eye	36.4 nTPM
Ovary	32.5 nTPM
Placenta	31.3 nTPM
Heart muscle	30.2 nTPM
Pancreas	23.1 nTPM
Lung	18.7 nTPM

Fibroblasts	82.0 nTPM
Adipose tissue	167.7 nTPM
Prostate	136.8 nTPM
Esophagus	116.2 nTPM
Skeletal muscle	93.2 nTPM
Skin	92.4 nTPM
Breast	73.4 nTPM
Lung	59.2 nTPM
Stomach	53.4 nTPM
Heart muscle	43.2 nTPM
Ovary	33.4 nTPM
Placenta	32.6 nTPM

Intestinal goblet cells	31.8 nTPM
Small intestine	38.3 nTPM
Rectum	36.5 nTPM
Colon	20.8 nTPM

Macrophages	39.9 nTPM
Adipose tissue	78.3 nTPM
Ovary	56.6 nTPM
Esophagus	55.1 nTPM
Prostate	50.4 nTPM
Stomach	49.8 nTPM
Breast	44.1 nTPM
Lung	41.8 nTPM
Testis	41.8 nTPM
Skeletal muscle	37.2 nTPM
Pancreas	35.7 nTPM
Kidney	30.3 nTPM
Endometrium	28.4 nTPM
Bone marrow	26.2 nTPM
Spleen	22.8 nTPM
PBMC	0.0 nTPM

Paneth cells	44.6 nTPM
Colon	52.6 nTPM
Rectum	51.0 nTPM
Small intestine	30.0 nTPM

Plasma cells	24.5 nTPM
Adipose tissue	40.7 nTPM
Stomach	31.1 nTPM
Bone marrow	19.8 nTPM
Spleen	18.5 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	41.2 nTPM
Lung	51.0 nTPM
Bronchus	31.3 nTPM

Smooth muscle cells	48.4 nTPM
Prostate	76.9 nTPM
Adipose tissue	60.9 nTPM
Skeletal muscle	57.7 nTPM
Ovary	57.0 nTPM
Skin	54.4 nTPM
Esophagus	48.0 nTPM
Breast	47.3 nTPM
Pancreas	42.8 nTPM
Endometrium	38.4 nTPM
Heart muscle	27.0 nTPM
Bronchus	21.6 nTPM

Cholangiocytes	62.9 nTPM
Liver	62.9 nTPM

Collecting duct cells	38.6 nTPM
Kidney	38.6 nTPM

Cone photoreceptor cells	27.1 nTPM
Eye	27.1 nTPM

Cytotrophoblasts	58.8 nTPM
Placenta	58.8 nTPM

T-cells	37.7 nTPM
Skin	123.8 nTPM
Adipose tissue	69.3 nTPM
Lymph node	46.4 nTPM
Breast	44.5 nTPM
Spleen	40.8 nTPM
Skeletal muscle	38.3 nTPM
PBMC	35.4 nTPM
Bone marrow	34.1 nTPM
Esophagus	32.8 nTPM
Colon	28.5 nTPM
Lung	25.8 nTPM
Stomach	24.5 nTPM
Kidney	24.0 nTPM
Liver	22.2 nTPM
Endometrium	20.4 nTPM
Ovary	15.6 nTPM
Prostate	14.2 nTPM

Undifferentiated cells	40.3 nTPM
Small intestine	47.3 nTPM
Rectum	44.8 nTPM
Colon	28.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC