Single cell type - UVRAG - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UVRAG
Gene descriptionⁱ Full gene name according to HGNC.	UV radiation resistance associated
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Microglial cells, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Microglial cells, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UVRAG is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RB1	RB transcriptional corepressor 1	0.6726	41
FCHO1	FCH and mu domain containing endocytic adaptor 1	0.6588	57
ATG4C	Autophagy related 4C cysteine peptidase	0.6064	42
CD74	CD74 molecule	0.5880	41
HLA-DOA	Major histocompatibility complex, class II, DO alpha	0.5875	41
ZCCHC7	Zinc finger CCHC-type containing 7	0.5768	57
ELMO1	Engulfment and cell motility 1	0.5713	42
MGAT5	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	0.5589	42
CD72	CD72 molecule	0.5502	57
PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing	0.5446	57
PLEKHG1	Pleckstrin homology and RhoGEF domain containing G1	0.5426	57
AP3B1	Adaptor related protein complex 3 subunit beta 1	0.5388	59
TBC1D5	TBC1 domain family member 5	0.5379	42
KBTBD8	Kelch repeat and BTB domain containing 8	0.5365	41
FAM13B	Family with sequence similarity 13 member B	0.5332	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	97.3 nTPM
Adipose tissue	105.4 nTPM
Breast	89.1 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	21.3 nTPM
Lung	21.3 nTPM

Astrocytes	53.8 nTPM
Brain	53.8 nTPM

Basal keratinocytes	9.2 nTPM
Skin	9.2 nTPM

B-cells	97.0 nTPM
Lymph node	145.4 nTPM
Bone marrow	143.9 nTPM
Stomach	124.0 nTPM
Adipose tissue	122.8 nTPM
Spleen	103.8 nTPM
Breast	92.2 nTPM
PBMC	77.1 nTPM
Colon	75.1 nTPM
Kidney	71.4 nTPM
Liver	14.2 nTPM

Dendritic cells	41.6 nTPM
PBMC	67.8 nTPM
Breast	29.5 nTPM
Adipose tissue	27.6 nTPM

Endothelial cells	36.5 nTPM
Skeletal muscle	67.4 nTPM
Esophagus	47.4 nTPM
Pancreas	42.5 nTPM
Breast	41.7 nTPM
Ovary	38.6 nTPM
Lung	37.4 nTPM
Eye	36.4 nTPM
Heart muscle	33.9 nTPM
Prostate	32.8 nTPM
Liver	32.1 nTPM
Skin	30.8 nTPM
Testis	28.2 nTPM
Endometrium	27.4 nTPM
Placenta	13.7 nTPM

Fibroblasts	24.7 nTPM
Stomach	46.0 nTPM
Esophagus	32.9 nTPM
Adipose tissue	31.2 nTPM
Breast	30.5 nTPM
Skeletal muscle	29.9 nTPM
Prostate	23.0 nTPM
Heart muscle	19.1 nTPM
Placenta	16.8 nTPM
Skin	16.8 nTPM
Lung	14.5 nTPM
Ovary	11.4 nTPM

Intestinal goblet cells	10.0 nTPM
Small intestine	11.4 nTPM
Rectum	9.5 nTPM
Colon	9.3 nTPM

Macrophages	46.3 nTPM
Adipose tissue	94.4 nTPM
Breast	75.0 nTPM
Skeletal muscle	66.9 nTPM
Bone marrow	61.2 nTPM
Endometrium	57.7 nTPM
Spleen	56.0 nTPM
Esophagus	55.1 nTPM
Stomach	43.9 nTPM
Ovary	43.1 nTPM
Testis	39.5 nTPM
Kidney	27.2 nTPM
Lung	22.4 nTPM
Prostate	20.7 nTPM
Pancreas	17.8 nTPM
PBMC	13.6 nTPM

Paneth cells	11.4 nTPM
Small intestine	15.0 nTPM
Rectum	12.6 nTPM
Colon	6.5 nTPM

Plasma cells	40.4 nTPM
Esophagus	80.1 nTPM
Stomach	42.5 nTPM
Adipose tissue	34.2 nTPM
Bone marrow	28.0 nTPM
Spleen	17.1 nTPM

Respiratory ciliated cells	6.5 nTPM
Bronchus	7.3 nTPM
Lung	5.8 nTPM

Smooth muscle cells	28.6 nTPM
Adipose tissue	74.7 nTPM
Esophagus	55.8 nTPM
Skeletal muscle	36.5 nTPM
Breast	36.1 nTPM
Endometrium	24.0 nTPM
Prostate	22.6 nTPM
Heart muscle	17.9 nTPM
Skin	16.8 nTPM
Ovary	16.3 nTPM
Pancreas	7.7 nTPM
Bronchus	6.8 nTPM

Cone photoreceptor cells	68.8 nTPM
Eye	68.8 nTPM

Cytotrophoblasts	37.6 nTPM
Placenta	37.6 nTPM

Distal tubular cells	7.9 nTPM
Kidney	7.9 nTPM

Early spermatids	6.2 nTPM
Testis	6.2 nTPM

T-cells	28.1 nTPM
Lymph node	49.6 nTPM
Spleen	46.8 nTPM
Bone marrow	44.4 nTPM
Stomach	44.0 nTPM
Skeletal muscle	36.3 nTPM
Adipose tissue	33.2 nTPM
Esophagus	32.8 nTPM
Breast	31.8 nTPM
Endometrium	27.7 nTPM
Lung	27.4 nTPM
PBMC	20.1 nTPM
Colon	19.5 nTPM
Skin	15.7 nTPM
Prostate	14.2 nTPM
Liver	12.9 nTPM
Kidney	11.6 nTPM
Ovary	8.9 nTPM

Undifferentiated cells	10.1 nTPM
Colon	12.0 nTPM
Rectum	9.7 nTPM
Small intestine	8.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC