Single cell type - LRBA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LRBA
Gene descriptionⁱ Full gene name according to HGNC.	LPS responsive beige-like anchor protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

LRBA is part of cluster 68 Oligodendrocytes - Mixed function with confidenceⁱ 0.72
161 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZSCAN25	Zinc finger and SCAN domain containing 25	0.5109	42
VWA8	Von Willebrand factor A domain containing 8	0.4839	8
KLF12	Kruppel like factor 12	0.4560	8
ARGFX	Arginine-fifty homeobox	0.4556	8
MARK1	Microtubule affinity regulating kinase 1	0.4500	8
RABGAP1L	RAB GTPase activating protein 1 like	0.4467	21
KIF26B	Kinesin family member 26B	0.4410	8
NLGN4X	Neuroligin 4 X-linked	0.4408	68
PCCA	Propionyl-CoA carboxylase subunit alpha	0.4367	68
RPTOR	Regulatory associated protein of MTOR complex 1	0.4365	42
PRKCQ	Protein kinase C theta	0.4346	24
MREG	Melanoregulin	0.4314	44
ZNF827	Zinc finger protein 827	0.4272	68
FBXO28	F-box protein 28	0.4255	22
ST3GAL6	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	0.4237	49

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.4 nTPM
Adipose tissue	11.0 nTPM
Breast	9.7 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	14.9 nTPM
Lung	14.9 nTPM

Astrocytes	148.5 nTPM
Brain	148.5 nTPM

B-cells	42.5 nTPM
Bone marrow	67.9 nTPM
Kidney	57.1 nTPM
Stomach	56.3 nTPM
Lymph node	54.7 nTPM
Spleen	52.9 nTPM
PBMC	35.7 nTPM
Adipose tissue	34.5 nTPM
Colon	28.7 nTPM
Liver	19.7 nTPM
Breast	17.3 nTPM

Dendritic cells	37.7 nTPM
Adipose tissue	46.7 nTPM
Breast	34.6 nTPM
PBMC	31.8 nTPM

Endothelial cells	13.3 nTPM
Heart muscle	39.5 nTPM
Testis	16.6 nTPM
Liver	16.5 nTPM
Skeletal muscle	15.8 nTPM
Eye	13.7 nTPM
Esophagus	12.8 nTPM
Endometrium	12.6 nTPM
Lung	12.5 nTPM
Skin	12.2 nTPM
Breast	11.9 nTPM
Ovary	9.3 nTPM
Prostate	7.4 nTPM
Placenta	5.1 nTPM
Pancreas	0.0 nTPM

Fibroblasts	12.8 nTPM
Heart muscle	30.6 nTPM
Ovary	16.9 nTPM
Esophagus	15.6 nTPM
Stomach	13.4 nTPM
Skeletal muscle	13.3 nTPM
Lung	11.1 nTPM
Skin	10.2 nTPM
Breast	10.0 nTPM
Adipose tissue	9.0 nTPM
Placenta	5.7 nTPM
Prostate	4.5 nTPM

Intestinal goblet cells	23.8 nTPM
Rectum	31.9 nTPM
Small intestine	27.4 nTPM
Colon	12.1 nTPM

Macrophages	17.7 nTPM
PBMC	109.1 nTPM
Bone marrow	17.5 nTPM
Endometrium	16.7 nTPM
Breast	15.6 nTPM
Kidney	14.3 nTPM
Adipose tissue	13.6 nTPM
Esophagus	12.6 nTPM
Stomach	11.7 nTPM
Prostate	11.5 nTPM
Skeletal muscle	11.4 nTPM
Testis	9.2 nTPM
Ovary	9.0 nTPM
Spleen	8.3 nTPM
Lung	5.2 nTPM
Pancreas	0.0 nTPM

Paneth cells	20.2 nTPM
Small intestine	30.0 nTPM
Rectum	24.1 nTPM
Colon	6.5 nTPM

Plasma cells	38.3 nTPM
Esophagus	49.4 nTPM
Adipose tissue	47.1 nTPM
Bone marrow	36.2 nTPM
Stomach	34.6 nTPM
Spleen	24.5 nTPM

Respiratory ciliated cells	36.7 nTPM
Bronchus	48.6 nTPM
Lung	24.8 nTPM

Smooth muscle cells	9.8 nTPM
Heart muscle	18.6 nTPM
Endometrium	13.3 nTPM
Adipose tissue	13.1 nTPM
Breast	10.3 nTPM
Bronchus	9.4 nTPM
Ovary	9.2 nTPM
Skin	8.7 nTPM
Skeletal muscle	8.7 nTPM
Prostate	6.9 nTPM
Pancreas	4.9 nTPM
Esophagus	4.6 nTPM

T-cells	45.6 nTPM
Bone marrow	73.4 nTPM
Stomach	70.0 nTPM
Spleen	62.6 nTPM
Esophagus	52.4 nTPM
Adipose tissue	50.8 nTPM
PBMC	50.5 nTPM
Lymph node	50.1 nTPM
Liver	44.3 nTPM
Kidney	43.8 nTPM
Skeletal muscle	42.5 nTPM
Colon	41.8 nTPM
Breast	41.2 nTPM
Skin	39.6 nTPM
Endometrium	38.8 nTPM
Ovary	35.6 nTPM
Prostate	19.0 nTPM
Lung	18.2 nTPM

Basal prostatic cells	16.4 nTPM
Prostate	16.4 nTPM

Basal respiratory cells	21.0 nTPM
Bronchus	21.0 nTPM

Basal squamous epithelial cells	28.5 nTPM
Esophagus	28.5 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Undifferentiated cells	27.2 nTPM
Rectum	34.8 nTPM
Small intestine	30.4 nTPM
Colon	16.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC