Single cell type - ZDHHC18 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZDHHC18
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger DHHC-type palmitoyltransferase 18
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZDHHC18 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RHOF	Ras homolog family member F, filopodia associated	0.5962	53
OASL	2'-5'-oligoadenylate synthetase like	0.5749	53
SIRT7	Sirtuin 7	0.5733	53
TMEM120B	Transmembrane protein 120B	0.5040	53
SPTAN1	Spectrin alpha, non-erythrocytic 1	0.4946	9
DEDD2	Death effector domain containing 2	0.4932	53
PLCD3	Phospholipase C delta 3	0.4928	53
FAM32A	Family with sequence similarity 32 member A	0.4859	53
SLC20A1	Solute carrier family 20 member 1	0.4821	53
CLCA4	Chloride channel accessory 4	0.4787	53
GTPBP1	GTP binding protein 1	0.4752	22
HRAS	HRas proto-oncogene, GTPase	0.4739	22
MYH14	Myosin heavy chain 14	0.4738	53
GIPC1	GIPC PDZ domain containing family member 1	0.4708	53
C17orf67	Chromosome 17 open reading frame 67	0.4686	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.9 nTPM
Adipose tissue	16.2 nTPM
Breast	9.5 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	7.9 nTPM
Lung	7.9 nTPM

Astrocytes	6.5 nTPM
Brain	6.5 nTPM

B-cells	7.5 nTPM
Breast	16.0 nTPM
Adipose tissue	13.5 nTPM
Liver	13.1 nTPM
Colon	12.8 nTPM
Lymph node	5.3 nTPM
Kidney	4.8 nTPM
Spleen	3.5 nTPM
Stomach	2.7 nTPM
Bone marrow	1.7 nTPM
PBMC	1.4 nTPM

Dendritic cells	21.2 nTPM
Adipose tissue	32.7 nTPM
Breast	22.9 nTPM
PBMC	8.0 nTPM

Endothelial cells	9.1 nTPM
Prostate	13.7 nTPM
Ovary	12.8 nTPM
Skeletal muscle	11.8 nTPM
Pancreas	11.6 nTPM
Eye	11.3 nTPM
Lung	9.3 nTPM
Placenta	8.6 nTPM
Liver	8.2 nTPM
Breast	8.2 nTPM
Skin	7.9 nTPM
Testis	7.1 nTPM
Heart muscle	6.2 nTPM
Endometrium	6.0 nTPM
Esophagus	5.2 nTPM

Fibroblasts	7.1 nTPM
Placenta	10.0 nTPM
Adipose tissue	9.3 nTPM
Ovary	9.1 nTPM
Skin	8.6 nTPM
Prostate	8.4 nTPM
Stomach	7.4 nTPM
Skeletal muscle	6.9 nTPM
Breast	6.2 nTPM
Lung	5.6 nTPM
Esophagus	5.1 nTPM
Heart muscle	1.6 nTPM

Intestinal goblet cells	3.9 nTPM
Rectum	5.8 nTPM
Small intestine	4.5 nTPM
Colon	1.4 nTPM

Macrophages	11.0 nTPM
PBMC	27.3 nTPM
Adipose tissue	17.1 nTPM
Breast	16.2 nTPM
Endometrium	15.7 nTPM
Skeletal muscle	14.7 nTPM
Lung	14.0 nTPM
Ovary	12.4 nTPM
Pancreas	10.2 nTPM
Kidney	8.3 nTPM
Esophagus	7.9 nTPM
Prostate	6.9 nTPM
Testis	5.2 nTPM
Spleen	5.2 nTPM
Bone marrow	3.7 nTPM
Stomach	0.0 nTPM

Paneth cells	25.6 nTPM
Colon	62.6 nTPM
Rectum	10.4 nTPM
Small intestine	3.7 nTPM

Plasma cells	8.3 nTPM
Adipose tissue	20.0 nTPM
Stomach	8.9 nTPM
Bone marrow	6.6 nTPM
Spleen	6.2 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	4.6 nTPM
Bronchus	9.2 nTPM
Lung	0.0 nTPM

Smooth muscle cells	6.2 nTPM
Ovary	10.7 nTPM
Skeletal muscle	7.9 nTPM
Adipose tissue	7.2 nTPM
Skin	7.0 nTPM
Endometrium	6.4 nTPM
Breast	6.3 nTPM
Prostate	6.2 nTPM
Pancreas	6.1 nTPM
Heart muscle	6.0 nTPM
Bronchus	2.8 nTPM
Esophagus	1.5 nTPM

T-cells	17.4 nTPM
Skin	38.2 nTPM
Adipose tissue	35.1 nTPM
Breast	29.8 nTPM
Colon	23.7 nTPM
Skeletal muscle	21.1 nTPM
Ovary	20.1 nTPM
Endometrium	19.1 nTPM
Spleen	18.0 nTPM
PBMC	16.6 nTPM
Liver	16.5 nTPM
Lymph node	12.2 nTPM
Bone marrow	11.1 nTPM
Stomach	10.4 nTPM
Prostate	9.5 nTPM
Lung	7.6 nTPM
Kidney	7.5 nTPM
Esophagus	0.0 nTPM

Basal respiratory cells	4.4 nTPM
Bronchus	4.4 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Cone photoreceptor cells	27.1 nTPM
Eye	27.1 nTPM

Cytotrophoblasts	10.6 nTPM
Placenta	10.6 nTPM

Undifferentiated cells	7.0 nTPM
Rectum	10.3 nTPM
Colon	6.5 nTPM
Small intestine	4.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC