Single cell type - TMEM120B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM120B
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 120B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Langerhans cells, NK-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Langerhans cells, NK-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM120B is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RHOF	Ras homolog family member F, filopodia associated	0.6447	53
ZDHHC18	Zinc finger DHHC-type palmitoyltransferase 18	0.5040	53
SIRT7	Sirtuin 7	0.4923	53
AAK1	AP2 associated kinase 1	0.4760	9
HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4	0.4700	53
TRIM40	Tripartite motif containing 40	0.4555	53
FAM32A	Family with sequence similarity 32 member A	0.4554	53
MED15	Mediator complex subunit 15	0.4487	63
MIER3	MIER family member 3	0.4457	53
EPS8L2	EPS8 like 2	0.4385	53
CLCA4	Chloride channel accessory 4	0.4375	53
KIF2A	Kinesin family member 2A	0.4301	51
SIRT6	Sirtuin 6	0.4261	53
CLDN23	Claudin 23	0.4257	53
UNC13D	Unc-13 homolog D	0.4229	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	3.3 nTPM
Breast	3.3 nTPM
Adipose tissue	3.2 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	12.2 nTPM
Lung	12.2 nTPM

Astrocytes	12.1 nTPM
Brain	12.1 nTPM

B-cells	14.0 nTPM
Adipose tissue	29.6 nTPM
PBMC	25.7 nTPM
Colon	16.0 nTPM
Breast	14.7 nTPM
Liver	12.7 nTPM
Spleen	10.7 nTPM
Kidney	9.5 nTPM
Stomach	7.7 nTPM
Bone marrow	6.6 nTPM
Lymph node	6.3 nTPM

Dendritic cells	45.9 nTPM
Adipose tissue	80.6 nTPM
Breast	29.2 nTPM
PBMC	27.9 nTPM

Endothelial cells	4.8 nTPM
Eye	7.3 nTPM
Liver	7.3 nTPM
Lung	6.2 nTPM
Skin	5.3 nTPM
Endometrium	5.2 nTPM
Heart muscle	5.1 nTPM
Testis	4.7 nTPM
Skeletal muscle	4.5 nTPM
Placenta	4.0 nTPM
Pancreas	3.9 nTPM
Ovary	3.7 nTPM
Prostate	3.3 nTPM
Breast	3.2 nTPM
Esophagus	3.1 nTPM

Fibroblasts	9.1 nTPM
Heart muscle	15.4 nTPM
Ovary	14.0 nTPM
Esophagus	9.2 nTPM
Skeletal muscle	9.0 nTPM
Stomach	8.9 nTPM
Placenta	8.8 nTPM
Lung	7.8 nTPM
Breast	7.5 nTPM
Skin	6.9 nTPM
Adipose tissue	6.3 nTPM
Prostate	6.2 nTPM

Intestinal goblet cells	4.9 nTPM
Colon	8.5 nTPM
Small intestine	3.4 nTPM
Rectum	2.8 nTPM

Macrophages	17.6 nTPM
PBMC	122.7 nTPM
Adipose tissue	38.7 nTPM
Endometrium	30.4 nTPM
Breast	12.0 nTPM
Skeletal muscle	10.5 nTPM
Prostate	10.3 nTPM
Lung	9.1 nTPM
Kidney	8.3 nTPM
Ovary	7.6 nTPM
Bone marrow	7.5 nTPM
Testis	4.0 nTPM
Esophagus	1.6 nTPM
Spleen	1.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	33.6 nTPM
Colon	92.2 nTPM
Rectum	5.0 nTPM
Small intestine	3.7 nTPM

Plasma cells	19.8 nTPM
Adipose tissue	35.5 nTPM
Esophagus	18.4 nTPM
Stomach	18.2 nTPM
Spleen	13.6 nTPM
Bone marrow	13.2 nTPM

Respiratory ciliated cells	15.7 nTPM
Bronchus	27.1 nTPM
Lung	4.4 nTPM

Smooth muscle cells	8.6 nTPM
Heart muscle	31.2 nTPM
Pancreas	11.4 nTPM
Bronchus	7.5 nTPM
Ovary	7.0 nTPM
Endometrium	6.8 nTPM
Skin	6.6 nTPM
Skeletal muscle	5.7 nTPM
Breast	5.4 nTPM
Esophagus	4.6 nTPM
Adipose tissue	4.5 nTPM
Prostate	4.1 nTPM

T-cells	28.0 nTPM
PBMC	52.4 nTPM
Adipose tissue	50.8 nTPM
Endometrium	45.7 nTPM
Liver	44.7 nTPM
Skeletal muscle	44.3 nTPM
Skin	42.8 nTPM
Kidney	39.7 nTPM
Breast	25.1 nTPM
Prostate	23.6 nTPM
Ovary	22.3 nTPM
Colon	18.5 nTPM
Bone marrow	17.3 nTPM
Stomach	13.4 nTPM
Esophagus	13.1 nTPM
Lymph node	8.8 nTPM
Spleen	8.8 nTPM
Lung	4.5 nTPM

Basal keratinocytes	6.5 nTPM
Skin	6.5 nTPM

Basal respiratory cells	6.5 nTPM
Bronchus	6.5 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Cone photoreceptor cells	22.9 nTPM
Eye	22.9 nTPM

Undifferentiated cells	5.4 nTPM
Colon	8.5 nTPM
Rectum	3.9 nTPM
Small intestine	3.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC