Single cell type - TRIM27 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIM27
Gene descriptionⁱ Full gene name according to HGNC.	Tripartite motif containing 27
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRIM27 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
AAR2	AAR2 splicing factor	0.5284	47
NOP14	NOP14 nucleolar protein	0.5260	10
PDCD2	Programmed cell death 2	0.5160	32
CELA1	Chymotrypsin like elastase 1	0.5135	1
SRP72	Signal recognition particle 72	0.5105	55
COA7	Cytochrome c oxidase assembly factor 7 (putative)	0.5047	10
MTDH	Metadherin	0.4991	55
ABCE1	ATP binding cassette subfamily E member 1	0.4971	39
XRN2	5'-3' exoribonuclease 2	0.4808	10
TMEM208	Transmembrane protein 208	0.4784	55
SPINK6	Serine peptidase inhibitor Kazal type 6	0.4747	22
WDR4	WD repeat domain 4	0.4740	39
RNASEH1	Ribonuclease H1	0.4739	55
NOC2L	NOC2 like nucleolar associated transcriptional repressor	0.4716	39
NR2C2AP	Nuclear receptor 2C2 associated protein	0.4657	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	21.4 nTPM
Breast	21.5 nTPM
Adipose tissue	21.3 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	24.8 nTPM
Lung	24.8 nTPM

Astrocytes	11.8 nTPM
Brain	11.8 nTPM

B-cells	32.2 nTPM
Lymph node	46.4 nTPM
Liver	42.6 nTPM
Spleen	39.4 nTPM
PBMC	34.3 nTPM
Stomach	32.7 nTPM
Bone marrow	28.6 nTPM
Breast	28.1 nTPM
Kidney	23.8 nTPM
Adipose tissue	23.6 nTPM
Colon	22.3 nTPM

Dendritic cells	25.4 nTPM
Breast	28.8 nTPM
PBMC	23.9 nTPM
Adipose tissue	23.3 nTPM

Endothelial cells	32.0 nTPM
Prostate	71.6 nTPM
Liver	47.7 nTPM
Ovary	40.1 nTPM
Testis	35.9 nTPM
Placenta	31.3 nTPM
Lung	31.2 nTPM
Esophagus	31.0 nTPM
Pancreas	30.9 nTPM
Heart muscle	29.9 nTPM
Skin	25.1 nTPM
Endometrium	23.4 nTPM
Breast	22.5 nTPM
Skeletal muscle	18.0 nTPM
Eye	8.9 nTPM

Fibroblasts	25.5 nTPM
Lung	49.2 nTPM
Ovary	46.2 nTPM
Prostate	39.0 nTPM
Placenta	28.1 nTPM
Breast	21.9 nTPM
Esophagus	20.0 nTPM
Skeletal muscle	18.5 nTPM
Skin	15.9 nTPM
Heart muscle	15.8 nTPM
Adipose tissue	15.5 nTPM
Stomach	10.4 nTPM

Intestinal goblet cells	38.5 nTPM
Colon	58.6 nTPM
Small intestine	32.3 nTPM
Rectum	24.6 nTPM

Macrophages	29.0 nTPM
Bone marrow	46.2 nTPM
Ovary	46.1 nTPM
Pancreas	46.0 nTPM
Kidney	41.5 nTPM
Spleen	32.1 nTPM
Lung	30.3 nTPM
Testis	30.3 nTPM
Esophagus	26.8 nTPM
Breast	26.5 nTPM
Skeletal muscle	24.7 nTPM
Prostate	22.9 nTPM
Endometrium	20.9 nTPM
Adipose tissue	20.6 nTPM
Stomach	20.5 nTPM
PBMC	0.0 nTPM

Paneth cells	18.7 nTPM
Colon	23.1 nTPM
Rectum	21.6 nTPM
Small intestine	11.3 nTPM

Plasma cells	51.2 nTPM
Spleen	64.6 nTPM
Stomach	58.2 nTPM
Bone marrow	52.7 nTPM
Esophagus	49.4 nTPM
Adipose tissue	31.0 nTPM

Respiratory ciliated cells	23.9 nTPM
Lung	26.2 nTPM
Bronchus	21.7 nTPM

Smooth muscle cells	31.0 nTPM
Bronchus	117.3 nTPM
Pancreas	44.6 nTPM
Ovary	40.2 nTPM
Prostate	23.7 nTPM
Endometrium	23.6 nTPM
Skin	17.8 nTPM
Breast	16.6 nTPM
Esophagus	15.5 nTPM
Adipose tissue	15.4 nTPM
Skeletal muscle	15.1 nTPM
Heart muscle	10.9 nTPM

T-cells	28.9 nTPM
PBMC	41.9 nTPM
Esophagus	39.3 nTPM
Bone marrow	38.1 nTPM
Lymph node	37.8 nTPM
Colon	30.9 nTPM
Spleen	30.6 nTPM
Liver	29.9 nTPM
Kidney	28.0 nTPM
Lung	27.4 nTPM
Ovary	26.7 nTPM
Skin	24.9 nTPM
Stomach	24.6 nTPM
Adipose tissue	24.5 nTPM
Breast	24.3 nTPM
Prostate	23.6 nTPM
Skeletal muscle	19.4 nTPM
Endometrium	19.2 nTPM

Basal keratinocytes	28.4 nTPM
Skin	28.4 nTPM

Basal squamous epithelial cells	33.6 nTPM
Esophagus	33.6 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Undifferentiated cells	28.3 nTPM
Colon	30.8 nTPM
Small intestine	28.6 nTPM
Rectum	25.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC