Single cell type - PDE7A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDE7A
Gene descriptionⁱ Full gene name according to HGNC.	Phosphodiesterase 7A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Inhibitory neurons, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Karpas-707, MOLT-4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PDE7A is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CXCR4	C-X-C motif chemokine receptor 4	0.6084	24
MSL2	MSL complex subunit 2	0.6048	24
RASGRP1	RAS guanyl releasing protein 1	0.5398	24
JADE2	Jade family PHD finger 2	0.5391	24
PPP2R5C	Protein phosphatase 2 regulatory subunit B'gamma	0.5340	24
RGPD2	RANBP2 like and GRIP domain containing 2	0.5257	24
STK4	Serine/threonine kinase 4	0.5143	24
CA5B	Carbonic anhydrase 5B	0.5131	24
VAMP1	Vesicle associated membrane protein 1	0.5121	8
SHISAL2A	Shisa like 2A	0.5100	7
GPR174	G protein-coupled receptor 174	0.5056	7
IDS	Iduronate 2-sulfatase	0.4987	24
ZRSR2	Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2	0.4962	7
BCL2	BCL2 apoptosis regulator	0.4949	64
TENT5C	Terminal nucleotidyltransferase 5C	0.4937	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.6 nTPM
Breast	9.2 nTPM
Adipose tissue	7.9 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	22.7 nTPM
Lung	22.7 nTPM

Astrocytes	41.4 nTPM
Brain	41.4 nTPM

B-cells	95.1 nTPM
Adipose tissue	246.1 nTPM
Colon	140.6 nTPM
Stomach	98.1 nTPM
Lymph node	96.2 nTPM
PBMC	91.3 nTPM
Spleen	77.2 nTPM
Bone marrow	67.0 nTPM
Kidney	66.6 nTPM
Breast	38.8 nTPM
Liver	29.1 nTPM

Dendritic cells	93.4 nTPM
Adipose tissue	179.0 nTPM
Breast	69.2 nTPM
PBMC	31.8 nTPM

Endothelial cells	7.9 nTPM
Skin	17.2 nTPM
Heart muscle	16.3 nTPM
Prostate	13.1 nTPM
Endometrium	8.9 nTPM
Ovary	8.6 nTPM
Breast	7.9 nTPM
Skeletal muscle	6.8 nTPM
Liver	6.4 nTPM
Lung	6.2 nTPM
Testis	5.9 nTPM
Eye	4.1 nTPM
Pancreas	3.9 nTPM
Placenta	2.9 nTPM
Esophagus	2.6 nTPM

Fibroblasts	17.2 nTPM
Skin	30.7 nTPM
Heart muscle	25.8 nTPM
Prostate	24.1 nTPM
Skeletal muscle	23.3 nTPM
Esophagus	17.2 nTPM
Adipose tissue	14.3 nTPM
Lung	13.4 nTPM
Breast	13.0 nTPM
Ovary	12.2 nTPM
Stomach	10.4 nTPM
Placenta	4.5 nTPM

Intestinal goblet cells	6.5 nTPM
Small intestine	9.8 nTPM
Rectum	6.7 nTPM
Colon	2.9 nTPM

Macrophages	26.2 nTPM
Adipose tissue	57.8 nTPM
Breast	41.6 nTPM
Prostate	40.1 nTPM
Spleen	35.3 nTPM
Ovary	30.9 nTPM
Skeletal muscle	29.5 nTPM
Endometrium	28.7 nTPM
Bone marrow	28.7 nTPM
Stomach	23.5 nTPM
Pancreas	20.4 nTPM
Esophagus	18.9 nTPM
Lung	16.3 nTPM
Kidney	12.9 nTPM
Testis	9.2 nTPM
PBMC	0.0 nTPM

Paneth cells	5.6 nTPM
Colon	6.5 nTPM
Rectum	6.5 nTPM
Small intestine	3.7 nTPM

Plasma cells	56.3 nTPM
Adipose tissue	214.8 nTPM
Stomach	27.2 nTPM
Spleen	13.9 nTPM
Bone marrow	13.2 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	20.3 nTPM
Lung	29.1 nTPM
Bronchus	11.5 nTPM

Smooth muscle cells	11.1 nTPM
Prostate	22.8 nTPM
Skin	16.8 nTPM
Ovary	16.7 nTPM
Endometrium	14.3 nTPM
Breast	11.5 nTPM
Adipose tissue	10.0 nTPM
Esophagus	7.8 nTPM
Skeletal muscle	7.5 nTPM
Heart muscle	7.3 nTPM
Pancreas	5.1 nTPM
Bronchus	1.8 nTPM

T-cells	81.3 nTPM
Adipose tissue	167.1 nTPM
Breast	138.4 nTPM
Skeletal muscle	107.0 nTPM
Endometrium	100.4 nTPM
PBMC	89.3 nTPM
Esophagus	85.2 nTPM
Ovary	84.5 nTPM
Spleen	83.9 nTPM
Lymph node	80.6 nTPM
Colon	80.3 nTPM
Liver	77.4 nTPM
Skin	68.6 nTPM
Bone marrow	56.6 nTPM
Stomach	53.7 nTPM
Kidney	48.6 nTPM
Lung	31.9 nTPM
Prostate	28.4 nTPM

Basal keratinocytes	18.1 nTPM
Skin	18.1 nTPM

Basal prostatic cells	13.6 nTPM
Prostate	13.6 nTPM

Basal respiratory cells	8.8 nTPM
Bronchus	8.8 nTPM

Basal squamous epithelial cells	7.4 nTPM
Esophagus	7.4 nTPM

Undifferentiated cells	6.5 nTPM
Small intestine	7.5 nTPM
Rectum	7.4 nTPM
Colon	4.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC